FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100062225> ?p ?o ?g. }

• W2100062225 abstract "We show how single-molecule unzipping experiments can provide strong evidence that the zero-force melting transition of long molecules of natural dsDNA should be classified as a phase transition of the higher-order type (continuous). Toward this end, we study a statistical-mechanics model for the fluctuating structure of a long molecule of dsDNA, and compute the equilibrium phase diagram for the experiment in which the molecule is unzipped under applied force. We consider a perfect-matching dsDNA model, in which the loops are volume-excluding chains with arbitrary loop exponent $c$. We include stacking interactions, hydrogen bonds, and main-chain entropy. We include sequence heterogeneity at the level of random sequences; in particular, there is no correlation in the base-pairing (bp) energy from one sequence position to the next. We present heuristic arguments to demonstrate that the low-temperature macrostate does not exhibit degenerate ergodicity breaking. We use this claim to understand the results of our replica-theoretic calculation of the equilibrium properties of the system. As a function of temperature, we obtain the minimal force at which the molecule separates completely. This critical-force curve is a line in the temperature-force phase diagram that marks the regions where the molecule exists primarily as a double helix versus the region where the molecule exists as two separate strands. We compare our random-sequence model to magnetic tweezer experiments performed on the $48text{ }502$ bp genome of bacteriophage $ensuremath{lambda}$. We find good agreement with the experimental data, which is restricted to temperatures between 24 and $50text{ }ifmmode^circelsetextdegreefi{}text{C}$. At higher temperatures, the critical-force curve of our random-sequence model is very different for that of the homogeneous-sequence version of our model. For both sequence models, the critical force falls to zero at the melting temperature ${T}_{c}$ like ${|Tensuremath{-}{T}_{c}|}^{ensuremath{alpha}}$. For the homogeneous-sequence model, $ensuremath{alpha}=1/2$ almost exactly, while for the random-sequence model, $ensuremath{alpha}ensuremath{approx}0.9$. Importantly, the shape of the critical-force curve is connected, via our theory, to the manner in which the helix fraction falls to zero at ${T}_{c}$. The helix fraction is the property that is used to classify the melting transition as a type of phase transition. In our calculation, the shape of the critical-force curve holds strong evidence that the zero-force melting transition of long natural dsDNA should be classified as a higher-order (continuous) phase transition. Specifically, the order is 3rd or greater." @default.
• W2100062225 created "2016-06-24" @default.
• W2100062225 creator A5017087150 @default.
• W2100062225 creator A5021752204 @default.
• W2100062225 creator A5066299112 @default.
• W2100062225 creator A5082765817 @default.
• W2100062225 date "2009-05-28" @default.
• W2100062225 modified "2023-09-26" @default.
• W2100062225 title "DNA unzipping phase diagram calculated via replica theory" @default.
• W2100062225 cites W1964176698 @default.
• W2100062225 cites W1964855214 @default.
• W2100062225 cites W1968860042 @default.
• W2100062225 cites W1971522357 @default.
• W2100062225 cites W1974799524 @default.
• W2100062225 cites W1983655186 @default.
• W2100062225 cites W1986466512 @default.
• W2100062225 cites W1989162094 @default.
• W2100062225 cites W1990351127 @default.
• W2100062225 cites W1993975059 @default.
• W2100062225 cites W2000249012 @default.
• W2100062225 cites W2005101591 @default.
• W2100062225 cites W2005429321 @default.
• W2100062225 cites W2009824138 @default.
• W2100062225 cites W2012881032 @default.
• W2100062225 cites W2015624198 @default.
• W2100062225 cites W2016160300 @default.
• W2100062225 cites W2019649074 @default.
• W2100062225 cites W2021076903 @default.
• W2100062225 cites W2027743880 @default.
• W2100062225 cites W2038358093 @default.
• W2100062225 cites W2040088156 @default.
• W2100062225 cites W2051999592 @default.
• W2100062225 cites W2053797131 @default.
• W2100062225 cites W2058273883 @default.
• W2100062225 cites W2064580019 @default.
• W2100062225 cites W2065751587 @default.
• W2100062225 cites W2081407528 @default.
• W2100062225 cites W2087117796 @default.
• W2100062225 cites W2088306370 @default.
• W2100062225 cites W2091254780 @default.
• W2100062225 cites W2126466006 @default.
• W2100062225 cites W2128589709 @default.
• W2100062225 cites W2143726250 @default.
• W2100062225 cites W2162310257 @default.
• W2100062225 cites W2256095228 @default.
• W2100062225 cites W2317706177 @default.
• W2100062225 cites W4253531794 @default.
• W2100062225 cites W2101297383 @default.
• W2100062225 doi "https://doi.org/10.1103/physreve.79.051923" @default.
• W2100062225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19518496" @default.
• W2100062225 hasPublicationYear "2009" @default.
• W2100062225 type Work @default.
• W2100062225 sameAs 2100062225 @default.
• W2100062225 citedByCount "1" @default.
• W2100062225 crossrefType "journal-article" @default.
• W2100062225 hasAuthorship W2100062225A5017087150 @default.
• W2100062225 hasAuthorship W2100062225A5021752204 @default.
• W2100062225 hasAuthorship W2100062225A5066299112 @default.
• W2100062225 hasAuthorship W2100062225A5082765817 @default.
• W2100062225 hasBestOaLocation W21000622252 @default.
• W2100062225 hasConcept C121332964 @default.
• W2100062225 hasConcept C121864883 @default.
• W2100062225 hasConcept C138885662 @default.
• W2100062225 hasConcept C2780388253 @default.
• W2100062225 hasConcept C41895202 @default.
• W2100062225 hasConcept C44280652 @default.
• W2100062225 hasConcept C62520636 @default.
• W2100062225 hasConcept C72319582 @default.
• W2100062225 hasConcept C85906118 @default.
• W2100062225 hasConcept C97355855 @default.
• W2100062225 hasConceptScore W2100062225C121332964 @default.
• W2100062225 hasConceptScore W2100062225C121864883 @default.
• W2100062225 hasConceptScore W2100062225C138885662 @default.
• W2100062225 hasConceptScore W2100062225C2780388253 @default.
• W2100062225 hasConceptScore W2100062225C41895202 @default.
• W2100062225 hasConceptScore W2100062225C44280652 @default.
• W2100062225 hasConceptScore W2100062225C62520636 @default.
• W2100062225 hasConceptScore W2100062225C72319582 @default.
• W2100062225 hasConceptScore W2100062225C85906118 @default.
• W2100062225 hasConceptScore W2100062225C97355855 @default.
• W2100062225 hasIssue "5" @default.
• W2100062225 hasLocation W21000622251 @default.
• W2100062225 hasLocation W21000622252 @default.
• W2100062225 hasLocation W21000622253 @default.
• W2100062225 hasLocation W21000622254 @default.
• W2100062225 hasOpenAccess W2100062225 @default.
• W2100062225 hasPrimaryLocation W21000622251 @default.
• W2100062225 hasRelatedWork W107440056 @default.
• W2100062225 hasRelatedWork W1924766363 @default.
• W2100062225 hasRelatedWork W2016823440 @default.
• W2100062225 hasRelatedWork W2027368907 @default.
• W2100062225 hasRelatedWork W2029522194 @default.
• W2100062225 hasRelatedWork W2041619579 @default.
• W2100062225 hasRelatedWork W2075483657 @default.
• W2100062225 hasRelatedWork W2407689329 @default.
• W2100062225 hasRelatedWork W2966352287 @default.
• W2100062225 hasRelatedWork W3159460229 @default.
• W2100062225 hasVolume "79" @default.
• W2100062225 isParatext "false" @default.
• W2100062225 isRetracted "false" @default.

• next