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- W2100063372 abstract "Hematopoiesis is maintained by stem cells (HSCs) that undergo fate decisions by integrating intrinsic and extrinsic signals, with the latter derived from the bone marrow (BM) microenvironment. Cell-cycle regulation can modulate stem cell fate, but it is unknown whether this represents an intrinsic or extrinsic effector of fate decisions. We have investigated the role of the retinoblastoma protein (RB), a central regulator of the cell cycle, in hematopoiesis. Widespread inactivation of RB in the murine hematopoietic system resulted in profound myeloproliferation. HSCs were lost from the BM due to mobilization to extramedullary sites and differentiation. This phenotype was not intrinsic to HSCs, but, rather, was the consequence of an RB-dependent interaction between myeloid-derived cells and the microenvironment. These findings demonstrate that myeloproliferation may result from perturbed interactions between hematopoietic cells and the niche. Therefore, RB extrinsically regulates HSCs by maintaining the capacity of the BM to support normal hematopoiesis and HSCs." @default.
- W2100063372 created "2016-06-24" @default.
- W2100063372 creator A5023785368 @default.
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- W2100063372 creator A5059040618 @default.
- W2100063372 creator A5082442667 @default.
- W2100063372 creator A5087291616 @default.
- W2100063372 date "2007-06-01" @default.
- W2100063372 modified "2023-10-13" @default.
- W2100063372 title "Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment" @default.
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- W2100063372 doi "https://doi.org/10.1016/j.cell.2007.03.055" @default.
- W2100063372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2768301" @default.
- W2100063372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17574022" @default.
- W2100063372 hasPublicationYear "2007" @default.
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