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- W2100064182 endingPage "1738" @default.
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- W2100064182 abstract "ABSTRACT The minichromosome maintenance (MCM) complex plays essential, conserved roles throughout DNA synthesis: first, as a component of the prereplication complex at origins and, then, as a helicase associated with replication forks. Here we use fission yeast ( Schizosaccharomyces pombe ) as a model to demonstrate a role for the MCM complex in protecting replication fork structure and promoting recovery from replication arrest. Loss of MCM function generates lethal double-strand breaks at sites of DNA synthesis during replication elongation, suggesting replication fork collapse. MCM function also maintains the stability of forks stalled by hydroxyurea that activate the replication checkpoint. In cells where the checkpoint is activated, Mcm4 binds the Cds1 kinase and undergoes Cds1-dependent phosphorylation. MCM proteins also interact with proteins involved in homologous recombination, which promotes recovery from arrest by ensuring normal mitosis. We suggest that the MCM complex links replication fork stabilization with checkpoint arrest and recovery through direct interactions with checkpoint and recombination proteins and that this role in S-phase genome stability is conserved from yeast to human cells." @default.
- W2100064182 created "2016-06-24" @default.
- W2100064182 creator A5010612497 @default.
- W2100064182 creator A5016762566 @default.
- W2100064182 creator A5019894766 @default.
- W2100064182 creator A5073817405 @default.
- W2100064182 date "2008-03-01" @default.
- W2100064182 modified "2023-10-16" @default.
- W2100064182 title "Minichromosome Maintenance Proteins Interact with Checkpoint and Recombination Proteins To Promote S-Phase Genome Stability" @default.
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- W2100064182 doi "https://doi.org/10.1128/mcb.01717-07" @default.
- W2100064182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2258774" @default.
- W2100064182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18180284" @default.