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- W2100064259 abstract "The X box in the DRA promoter of the human histocompatibility complex is required for expression of the DRA gene in B cells. We show that a B-cell factor binds to a sequence that is clearly distinguishable from binding sites for the previously described X box binding nuclear proteins RF-X, NF-X, NF-Xc, NF-S, hXBP, and AP-1. Mutations in the DRA X box that disrupt the binding of this factor result in a lower level of gene expression, as does the presence of Id (a trans-dominant regulatory protein that negatively regulates helix-loop-helix proteins). Furthermore, this factor is recognized by antibodies directed against the helix-loop-helix protein A1, a mouse homolog of the immunoglobulin enhancer binding proteins E12/E47, and it binds to sequences in other genes that were previously shown to bind these proteins. By these criteria, this factor is BCF-1." @default.
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- W2100064259 date "1992-05-01" @default.
- W2100064259 modified "2023-09-23" @default.
- W2100064259 title "B-cell factor 1 is required for optimal expression of the DRA promoter in B cells" @default.
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- W2100064259 doi "https://doi.org/10.1128/mcb.12.5.2383-2390.1992" @default.
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