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- W2100064276 abstract "Abstract A recently improved understanding of gut immunity has merged with current thinking in biological and medical science, pointing to an apparent function of the mammalian cecal appendix as a safe‐house for symbiotic gut microbes, preserving the flora during times of gastrointestinal infection in societies without modern medicine. This function is potentially a selective force for the evolution and maintenance of the appendix, and provides an impetus for reassessment of the evolution of the appendix. A comparative anatomical approach reveals three apparent morphotypes of the cecal appendix, as well as appendix‐like structures in some species that lack a true cecal appendix. Cladistic analyses indicate that the appendix has evolved independently at least twice (at least once in diprotodont marsupials and at least once in Euarchontoglires), shows a highly significant ( P < 0.0001) phylogenetic signal in its distribution, and has been maintained in mammalian evolution for 80 million years or longer." @default.
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- W2100064276 date "2009-09-14" @default.
- W2100064276 modified "2023-10-17" @default.
- W2100064276 title "Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix" @default.
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- W2100064276 doi "https://doi.org/10.1111/j.1420-9101.2009.01809.x" @default.
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