Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100064735> ?p ?o ?g. }
- W2100064735 endingPage "150" @default.
- W2100064735 startingPage "139" @default.
- W2100064735 abstract "Abstract Objective The pathologic validation of European Alzheimer's Disease Consortium Alzheimer’s Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP). Methods Temporal lobes of nine Alzheimer's disease (AD) and seven cognitively normal subjects were scanned post‐mortem at 7 Tesla. Hippocampal volumes were obtained with HarP. Six‐micrometer‐thick hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet. Hippocampal subfields were manually traced. Neuronal counts, Aβ, and tau burden for each hippocampal subfield were obtained. Results We found significant correlations between hippocampal volume and Braak and Braak staging (ρ = −0.75, P = .001), tau (ρ = −0.53, P = .034), Aβ burden (ρ = −0.61, P = .012), and neuronal count (ρ = 0.77, P < .001). Exploratory subfield‐wise significant associations were found for Aβ in Cornu Ammonis (CA)1 (ρ = −0.58, P = .019) and subiculum (ρ = −0.75, P = .001), tau in CA2 (ρ = −0.59, P = .016), and CA3 (ρ = −0.5, P = .047), and neuronal count in CA1 (ρ = 0.55, P = .028), CA3 (ρ = 0.65, P = .006), and CA4 (ρ = 0.76, P = .001). Conclusions The observed associations provide pathological confirmation of hippocampal morphometry as a valid biomarker for AD and pathologic validation of HarP." @default.
- W2100064735 created "2016-06-24" @default.
- W2100064735 creator A5000967147 @default.
- W2100064735 creator A5004690805 @default.
- W2100064735 creator A5005099850 @default.
- W2100064735 creator A5006359053 @default.
- W2100064735 creator A5012184734 @default.
- W2100064735 creator A5015109247 @default.
- W2100064735 creator A5018885234 @default.
- W2100064735 creator A5027835558 @default.
- W2100064735 creator A5029597969 @default.
- W2100064735 creator A5032770351 @default.
- W2100064735 creator A5033942521 @default.
- W2100064735 creator A5034489901 @default.
- W2100064735 creator A5036655510 @default.
- W2100064735 creator A5040650353 @default.
- W2100064735 creator A5041074837 @default.
- W2100064735 creator A5042301990 @default.
- W2100064735 creator A5047356874 @default.
- W2100064735 creator A5052981165 @default.
- W2100064735 creator A5054177504 @default.
- W2100064735 creator A5055991293 @default.
- W2100064735 creator A5063318487 @default.
- W2100064735 creator A5065322925 @default.
- W2100064735 creator A5067136993 @default.
- W2100064735 creator A5068135140 @default.
- W2100064735 creator A5072481624 @default.
- W2100064735 creator A5073660758 @default.
- W2100064735 creator A5079862221 @default.
- W2100064735 creator A5085274264 @default.
- W2100064735 creator A5088896716 @default.
- W2100064735 creator A5091479473 @default.
- W2100064735 date "2015-01-22" @default.
- W2100064735 modified "2023-10-17" @default.
- W2100064735 title "Relationship between hippocampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC‐ADNI Harmonized Hippocampal Segmentation Protocol" @default.
- W2100064735 cites W10604852 @default.
- W2100064735 cites W1508239224 @default.
- W2100064735 cites W1550362224 @default.
- W2100064735 cites W1783390479 @default.
- W2100064735 cites W1815544646 @default.
- W2100064735 cites W1966879670 @default.
- W2100064735 cites W1968348960 @default.
- W2100064735 cites W1974300727 @default.
- W2100064735 cites W1977498848 @default.
- W2100064735 cites W1978482448 @default.
- W2100064735 cites W1980225806 @default.
- W2100064735 cites W1984748043 @default.
- W2100064735 cites W1985747467 @default.
- W2100064735 cites W1988963873 @default.
- W2100064735 cites W1990626187 @default.
- W2100064735 cites W1997350245 @default.
- W2100064735 cites W2006805877 @default.
- W2100064735 cites W2014892312 @default.
- W2100064735 cites W2016624400 @default.
- W2100064735 cites W2023916538 @default.
- W2100064735 cites W2025693096 @default.
- W2100064735 cites W2029800492 @default.
- W2100064735 cites W2029923284 @default.
- W2100064735 cites W2030716347 @default.
- W2100064735 cites W2033917523 @default.
- W2100064735 cites W2042940752 @default.
- W2100064735 cites W2043073239 @default.
- W2100064735 cites W2044367669 @default.
- W2100064735 cites W2048251539 @default.
- W2100064735 cites W2052742260 @default.
- W2100064735 cites W2066462635 @default.
- W2100064735 cites W2068338689 @default.
- W2100064735 cites W2071831557 @default.
- W2100064735 cites W2074274706 @default.
- W2100064735 cites W2085182512 @default.
- W2100064735 cites W2086978209 @default.
- W2100064735 cites W2088269376 @default.
- W2100064735 cites W2089588548 @default.
- W2100064735 cites W2090537659 @default.
- W2100064735 cites W2095422335 @default.
- W2100064735 cites W2106775021 @default.
- W2100064735 cites W2113802523 @default.
- W2100064735 cites W2116464190 @default.
- W2100064735 cites W2123720427 @default.
- W2100064735 cites W2125512901 @default.
- W2100064735 cites W2129771097 @default.
- W2100064735 cites W2132948185 @default.
- W2100064735 cites W2145055168 @default.
- W2100064735 cites W2151384687 @default.
- W2100064735 cites W2162319029 @default.
- W2100064735 cites W2165570456 @default.
- W2100064735 cites W2167873129 @default.
- W2100064735 cites W2168515699 @default.
- W2100064735 cites W2188997093 @default.
- W2100064735 cites W279887307 @default.
- W2100064735 doi "https://doi.org/10.1016/j.jalz.2015.01.001" @default.
- W2100064735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4348340" @default.
- W2100064735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25620800" @default.
- W2100064735 hasPublicationYear "2015" @default.
- W2100064735 type Work @default.
- W2100064735 sameAs 2100064735 @default.
- W2100064735 citedByCount "59" @default.
- W2100064735 countsByYear W21000647352014 @default.