FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100064880> ?p ?o ?g. }

• W2100064880 endingPage "310" @default.
• W2100064880 startingPage "305" @default.
• W2100064880 abstract "Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the development of analogues of classical antimalarial agents, appropriately modified in order to restore their relevance in antimalarial chemotherapy. Following this line of thought, the design, synthesis and in vitro evaluation of N-cinnamoylated quinacrine surrogates, 9-(N-cinnamoylaminobutyl)-amino-6-chloro-2-methoxyacridines, is reported. The compounds were found to be highly potent against both blood-stage P. falciparum, chloroquine-sensitive 3D7 (IC50=17.0–39.0 nM) and chloroquine-resistant W2 and Dd2 strains (IC50=3.2–41.2 and 27.1–131.0 nM, respectively), and liver-stage P. berghei (IC50=1.6–4.9 μM) parasites. These findings bring new hope for the possible future “rise of a fallen angel” in antimalarial chemotherapy, with a potential resurgence of quinacrine-related compounds as dual-stage antimalarial leads." @default.
• W2100064880 created "2016-06-24" @default.
• W2100064880 creator A5003147063 @default.
• W2100064880 creator A5019830706 @default.
• W2100064880 creator A5023434488 @default.
• W2100064880 creator A5029566297 @default.
• W2100064880 creator A5032082902 @default.
• W2100064880 creator A5060266961 @default.
• W2100064880 creator A5079626366 @default.
• W2100064880 creator A5080492091 @default.
• W2100064880 date "2013-12-27" @default.
• W2100064880 modified "2023-09-25" @default.
• W2100064880 title "<i>N-</i>Cinnamoylation of Antimalarial Classics: Quinacrine Analogues with Decreased Toxicity and Dual-Stage Activity" @default.
• W2100064880 cites W1968412982 @default.
• W2100064880 cites W1978734050 @default.
• W2100064880 cites W1986303437 @default.
• W2100064880 cites W1996669973 @default.
• W2100064880 cites W2001124223 @default.
• W2100064880 cites W2005313354 @default.
• W2100064880 cites W2009614747 @default.
• W2100064880 cites W2025004806 @default.
• W2100064880 cites W2030143165 @default.
• W2100064880 cites W2038217580 @default.
• W2100064880 cites W2048582801 @default.
• W2100064880 cites W2050164638 @default.
• W2100064880 cites W2070160936 @default.
• W2100064880 cites W2079908295 @default.
• W2100064880 cites W2083354933 @default.
• W2100064880 cites W2088536968 @default.
• W2100064880 cites W2096564318 @default.
• W2100064880 cites W2111023447 @default.
• W2100064880 cites W2115047515 @default.
• W2100064880 cites W2128305837 @default.
• W2100064880 cites W2128694903 @default.
• W2100064880 cites W2133541091 @default.
• W2100064880 cites W2149025394 @default.
• W2100064880 cites W2153722729 @default.
• W2100064880 cites W2171984852 @default.
• W2100064880 cites W2329668034 @default.
• W2100064880 cites W2415431679 @default.
• W2100064880 cites W4235067832 @default.
• W2100064880 cites W2020326612 @default.
• W2100064880 doi "https://doi.org/10.1002/cmdc.201300459" @default.
• W2100064880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24474655" @default.
• W2100064880 hasPublicationYear "2013" @default.
• W2100064880 type Work @default.
• W2100064880 sameAs 2100064880 @default.
• W2100064880 citedByCount "24" @default.
• W2100064880 countsByYear W21000648802014 @default.
• W2100064880 countsByYear W21000648802015 @default.
• W2100064880 countsByYear W21000648802016 @default.
• W2100064880 countsByYear W21000648802017 @default.
• W2100064880 countsByYear W21000648802018 @default.
• W2100064880 countsByYear W21000648802019 @default.
• W2100064880 countsByYear W21000648802020 @default.
• W2100064880 countsByYear W21000648802021 @default.
• W2100064880 countsByYear W21000648802022 @default.
• W2100064880 countsByYear W21000648802023 @default.
• W2100064880 crossrefType "journal-article" @default.
• W2100064880 hasAuthorship W2100064880A5003147063 @default.
• W2100064880 hasAuthorship W2100064880A5019830706 @default.
• W2100064880 hasAuthorship W2100064880A5023434488 @default.
• W2100064880 hasAuthorship W2100064880A5029566297 @default.
• W2100064880 hasAuthorship W2100064880A5032082902 @default.
• W2100064880 hasAuthorship W2100064880A5060266961 @default.
• W2100064880 hasAuthorship W2100064880A5079626366 @default.
• W2100064880 hasAuthorship W2100064880A5080492091 @default.
• W2100064880 hasBestOaLocation W21000648802 @default.
• W2100064880 hasConcept C114851261 @default.
• W2100064880 hasConcept C202751555 @default.
• W2100064880 hasConcept C203014093 @default.
• W2100064880 hasConcept C2777237215 @default.
• W2100064880 hasConcept C2777425658 @default.
• W2100064880 hasConcept C2777752497 @default.
• W2100064880 hasConcept C2778048844 @default.
• W2100064880 hasConcept C2778371730 @default.
• W2100064880 hasConcept C2908859342 @default.
• W2100064880 hasConcept C55493867 @default.
• W2100064880 hasConcept C86803240 @default.
• W2100064880 hasConcept C89423630 @default.
• W2100064880 hasConcept C98274493 @default.
• W2100064880 hasConceptScore W2100064880C114851261 @default.
• W2100064880 hasConceptScore W2100064880C202751555 @default.
• W2100064880 hasConceptScore W2100064880C203014093 @default.
• W2100064880 hasConceptScore W2100064880C2777237215 @default.
• W2100064880 hasConceptScore W2100064880C2777425658 @default.
• W2100064880 hasConceptScore W2100064880C2777752497 @default.
• W2100064880 hasConceptScore W2100064880C2778048844 @default.
• W2100064880 hasConceptScore W2100064880C2778371730 @default.
• W2100064880 hasConceptScore W2100064880C2908859342 @default.
• W2100064880 hasConceptScore W2100064880C55493867 @default.
• W2100064880 hasConceptScore W2100064880C86803240 @default.
• W2100064880 hasConceptScore W2100064880C89423630 @default.
• W2100064880 hasConceptScore W2100064880C98274493 @default.
• W2100064880 hasIssue "2" @default.
• W2100064880 hasLocation W21000648801 @default.
• W2100064880 hasLocation W21000648802 @default.
• W2100064880 hasLocation W21000648803 @default.

• next