FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100065945> ?p ?o ?g. }

• W2100065945 endingPage "543" @default.
• W2100065945 startingPage "534" @default.
• W2100065945 abstract "Increasing evidence has indicated that perturbation of cyclins is one of the major factors leading to cancer. The aim of this study was not only to investigate various cell cycle-related kinase activities in hepatocellular carcinoma (HCC), but also to analyze the difference of cell cycle-related kinase activity levels between hepatitis C virus (HCV)-induced HCC and HCV-induced cirrhosis. The protein levels of cyclins D1, E, A, and H, and of cyclin dependent kinase 1 (Cdk1), Cdk2, Cdk4, Cdk6, and Cdk7 in HCC and in surrounding nontumorous cirrhosis were determined by Western blot. The enzymatic activities of cyclins D1, E, A, Cdk1, Cdk4, Cdk6, Cdk7, and Wee1 were measured using in vitro kinase assays. Protein levels and kinase activities of cyclin D1, Cdk4, cyclin E, cyclin A, and Wee1 were significantly elevated in HCC compared with surrounding cirrhotic tissues. The enhanced cyclin D1-related kinase activity in HCC was accompanied by the up-regulation of Cdk4 activity, but not Cdk6 activity. The kinase activities of Cdk6, Cdk7, and Cdk1 did not differ between HCC and surrounding cirrhotic tissues. In addition, the protein levels and kinase activities of cyclin D1, Cdk4, and cyclin E were higher in poorly differentiated HCC and advanced HCC. In conclusion, the increases of cyclin D1, Cdk4, cyclin E, cyclin A, and Wee1 play an important role in the development of HCC from cirrhosis. Cyclin D1, Cdk4, and cyclin E activation may be closely related to the histopathologic grade and progression of HCC." @default.
• W2100065945 created "2016-06-24" @default.
• W2100065945 creator A5005637906 @default.
• W2100065945 creator A5017931660 @default.
• W2100065945 creator A5023553051 @default.
• W2100065945 creator A5029677330 @default.
• W2100065945 creator A5030488480 @default.
• W2100065945 creator A5034244372 @default.
• W2100065945 creator A5055436829 @default.
• W2100065945 creator A5057839325 @default.
• W2100065945 creator A5066364689 @default.
• W2100065945 creator A5069440561 @default.
• W2100065945 creator A5085316776 @default.
• W2100065945 creator A5091010100 @default.
• W2100065945 date "2003-03-01" @default.
• W2100065945 modified "2023-10-16" @default.
• W2100065945 title "Cyclins and cyclin-dependent kinases: Comparative study of hepatocellular carcinoma versus cirrhosis" @default.
• W2100065945 cites W177968855 @default.
• W2100065945 cites W1981981304 @default.
• W2100065945 cites W1982023234 @default.
• W2100065945 cites W1987944428 @default.
• W2100065945 cites W1989781896 @default.
• W2100065945 cites W1990925999 @default.
• W2100065945 cites W1994066190 @default.
• W2100065945 cites W1994082723 @default.
• W2100065945 cites W1996402807 @default.
• W2100065945 cites W1996741456 @default.
• W2100065945 cites W1997073961 @default.
• W2100065945 cites W1998001782 @default.
• W2100065945 cites W2003008937 @default.
• W2100065945 cites W2006052997 @default.
• W2100065945 cites W2027558915 @default.
• W2100065945 cites W2027655764 @default.
• W2100065945 cites W2028206784 @default.
• W2100065945 cites W2029080338 @default.
• W2100065945 cites W2048721919 @default.
• W2100065945 cites W2055595737 @default.
• W2100065945 cites W2075793367 @default.
• W2100065945 cites W2078596153 @default.
• W2100065945 cites W2080684315 @default.
• W2100065945 cites W2082598223 @default.
• W2100065945 cites W2092288709 @default.
• W2100065945 cites W2093115805 @default.
• W2100065945 cites W2100837269 @default.
• W2100065945 cites W2101108802 @default.
• W2100065945 cites W2127649862 @default.
• W2100065945 cites W2159954692 @default.
• W2100065945 cites W31572314 @default.
• W2100065945 cites W4293247451 @default.
• W2100065945 cites W2047953965 @default.
• W2100065945 cites W2085657688 @default.
• W2100065945 doi "https://doi.org/10.1053/jhep.2003.50112" @default.
• W2100065945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12601350" @default.
• W2100065945 hasPublicationYear "2003" @default.
• W2100065945 type Work @default.
• W2100065945 sameAs 2100065945 @default.
• W2100065945 citedByCount "171" @default.
• W2100065945 countsByYear W21000659452012 @default.
• W2100065945 countsByYear W21000659452013 @default.
• W2100065945 countsByYear W21000659452014 @default.
• W2100065945 countsByYear W21000659452015 @default.
• W2100065945 countsByYear W21000659452016 @default.
• W2100065945 countsByYear W21000659452017 @default.
• W2100065945 countsByYear W21000659452018 @default.
• W2100065945 countsByYear W21000659452019 @default.
• W2100065945 countsByYear W21000659452020 @default.
• W2100065945 countsByYear W21000659452021 @default.
• W2100065945 countsByYear W21000659452022 @default.
• W2100065945 countsByYear W21000659452023 @default.
• W2100065945 crossrefType "journal-article" @default.
• W2100065945 hasAuthorship W2100065945A5005637906 @default.
• W2100065945 hasAuthorship W2100065945A5017931660 @default.
• W2100065945 hasAuthorship W2100065945A5023553051 @default.
• W2100065945 hasAuthorship W2100065945A5029677330 @default.
• W2100065945 hasAuthorship W2100065945A5030488480 @default.
• W2100065945 hasAuthorship W2100065945A5034244372 @default.
• W2100065945 hasAuthorship W2100065945A5055436829 @default.
• W2100065945 hasAuthorship W2100065945A5057839325 @default.
• W2100065945 hasAuthorship W2100065945A5066364689 @default.
• W2100065945 hasAuthorship W2100065945A5069440561 @default.
• W2100065945 hasAuthorship W2100065945A5085316776 @default.
• W2100065945 hasAuthorship W2100065945A5091010100 @default.
• W2100065945 hasBestOaLocation W21000659451 @default.
• W2100065945 hasConcept C11882975 @default.
• W2100065945 hasConcept C120504264 @default.
• W2100065945 hasConcept C124320809 @default.
• W2100065945 hasConcept C1491633281 @default.
• W2100065945 hasConcept C16438837 @default.
• W2100065945 hasConcept C199649820 @default.
• W2100065945 hasConcept C199835354 @default.
• W2100065945 hasConcept C28179978 @default.
• W2100065945 hasConcept C29537977 @default.
• W2100065945 hasConcept C502942594 @default.
• W2100065945 hasConcept C55493867 @default.
• W2100065945 hasConcept C86803240 @default.
• W2100065945 hasConcept C94561458 @default.
• W2100065945 hasConcept C9743823 @default.
• W2100065945 hasConceptScore W2100065945C11882975 @default.

• next