FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100067436> ?p ?o ?g. }

• W2100067436 endingPage "4094" @default.
• W2100067436 startingPage "4085" @default.
• W2100067436 abstract "Organelles of the endomembrane system need to counterbalance fission and fusion events to maintain their surface-to-volume ratio. At the late mammalian endosome, the Rab GTPase Rab7 is a major regulator of fusion, whereas the homologous yeast protein Ypt7 seems to be restricted to the vacuole surface. Here, we present evidence that Ypt7 is recruited to and acts on late endosomes, where it affects multiple trafficking reactions. We show that overexpression of Ypt7 results in expansion and massive invagination of the vacuolar membrane, which requires cycling of Ypt7 between GDP- and GTP-bound states. Invaginations are blocked by ESCRT, CORVET and retromer mutants, but not by autophagy or AP-3 mutants. We also show that Ypt7-GTP specifically binds to the retromer cargo-recognition subcomplex, which--like its cargo Vps10--is found on the vacuole upon Ypt7 overproduction. Our data suggest that Ypt7 functions at the late endosome to coordinate retromer-mediated recycling with the fusion of late endosomes with vacuoles." @default.
• W2100067436 created "2016-06-24" @default.
• W2100067436 creator A5013559112 @default.
• W2100067436 creator A5021030878 @default.
• W2100067436 creator A5023704791 @default.
• W2100067436 creator A5032157673 @default.
• W2100067436 creator A5033126059 @default.
• W2100067436 creator A5040583807 @default.
• W2100067436 creator A5048417073 @default.
• W2100067436 creator A5064172362 @default.
• W2100067436 date "2010-12-01" @default.
• W2100067436 modified "2023-10-13" @default.
• W2100067436 title "The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosome" @default.
• W2100067436 cites W1550580251 @default.
• W2100067436 cites W1598680533 @default.
• W2100067436 cites W1966072209 @default.
• W2100067436 cites W1966322334 @default.
• W2100067436 cites W1980828899 @default.
• W2100067436 cites W1981515958 @default.
• W2100067436 cites W1989914444 @default.
• W2100067436 cites W1993735775 @default.
• W2100067436 cites W2001642664 @default.
• W2100067436 cites W2008909409 @default.
• W2100067436 cites W2018807628 @default.
• W2100067436 cites W2031231011 @default.
• W2100067436 cites W2031863264 @default.
• W2100067436 cites W2044191234 @default.
• W2100067436 cites W2063129130 @default.
• W2100067436 cites W2064142522 @default.
• W2100067436 cites W2069789629 @default.
• W2100067436 cites W2070740225 @default.
• W2100067436 cites W2071239489 @default.
• W2100067436 cites W2071651805 @default.
• W2100067436 cites W2072317853 @default.
• W2100067436 cites W2076480502 @default.
• W2100067436 cites W2079368124 @default.
• W2100067436 cites W2079911954 @default.
• W2100067436 cites W2080226687 @default.
• W2100067436 cites W2094205174 @default.
• W2100067436 cites W2121560523 @default.
• W2100067436 cites W2126003136 @default.
• W2100067436 cites W2131097779 @default.
• W2100067436 cites W2132005005 @default.
• W2100067436 cites W2136558879 @default.
• W2100067436 cites W2137372494 @default.
• W2100067436 cites W2140324218 @default.
• W2100067436 cites W2140758058 @default.
• W2100067436 cites W2145272227 @default.
• W2100067436 cites W2150104537 @default.
• W2100067436 cites W2154046032 @default.
• W2100067436 cites W2166155213 @default.
• W2100067436 cites W2167088833 @default.
• W2100067436 cites W2168210128 @default.
• W2100067436 cites W2170283917 @default.
• W2100067436 cites W330282323 @default.
• W2100067436 cites W4243195227 @default.
• W2100067436 doi "https://doi.org/10.1242/jcs.071977" @default.
• W2100067436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21062894" @default.
• W2100067436 hasPublicationYear "2010" @default.
• W2100067436 type Work @default.
• W2100067436 sameAs 2100067436 @default.
• W2100067436 citedByCount "95" @default.
• W2100067436 countsByYear W21000674362012 @default.
• W2100067436 countsByYear W21000674362013 @default.
• W2100067436 countsByYear W21000674362014 @default.
• W2100067436 countsByYear W21000674362015 @default.
• W2100067436 countsByYear W21000674362016 @default.
• W2100067436 countsByYear W21000674362017 @default.
• W2100067436 countsByYear W21000674362018 @default.
• W2100067436 countsByYear W21000674362019 @default.
• W2100067436 countsByYear W21000674362020 @default.
• W2100067436 countsByYear W21000674362021 @default.
• W2100067436 countsByYear W21000674362022 @default.
• W2100067436 countsByYear W21000674362023 @default.
• W2100067436 crossrefType "journal-article" @default.
• W2100067436 hasAuthorship W2100067436A5013559112 @default.
• W2100067436 hasAuthorship W2100067436A5021030878 @default.
• W2100067436 hasAuthorship W2100067436A5023704791 @default.
• W2100067436 hasAuthorship W2100067436A5032157673 @default.
• W2100067436 hasAuthorship W2100067436A5033126059 @default.
• W2100067436 hasAuthorship W2100067436A5040583807 @default.
• W2100067436 hasAuthorship W2100067436A5048417073 @default.
• W2100067436 hasAuthorship W2100067436A5064172362 @default.
• W2100067436 hasBestOaLocation W21000674361 @default.
• W2100067436 hasConcept C102568950 @default.
• W2100067436 hasConcept C102747710 @default.
• W2100067436 hasConcept C103038307 @default.
• W2100067436 hasConcept C104317684 @default.
• W2100067436 hasConcept C131934819 @default.
• W2100067436 hasConcept C143876685 @default.
• W2100067436 hasConcept C145458877 @default.
• W2100067436 hasConcept C156728348 @default.
• W2100067436 hasConcept C190062978 @default.
• W2100067436 hasConcept C207332259 @default.
• W2100067436 hasConcept C2780298669 @default.
• W2100067436 hasConcept C41625074 @default.
• W2100067436 hasConcept C55493867 @default.
• W2100067436 hasConcept C57581600 @default.

• next