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• W2100067495 abstract "ABSTRACT It was previously demonstrated that immunizing mice with spleen dendritic cells (DCs) that had been pulsed ex vivo with Toxoplasma gondii antigens triggers a systemic Th1-biased specific immune response and induces protection against infection. T. gondii can cause severe sequelae in the fetuses of mothers who acquire the infection during pregnancy, as well as life-threatening neuropathy in immunocompromised patients, in particular those with AIDS. Here, we investigate the efficacy of a novel cell-free vaccine composed of DC exosomes, which are secreted antigen-presenting vesicles that express functional major histocompatibility complex class I and II and T-cell-costimulatory molecules. They have already been shown to induce potent antitumor immune responses. We investigated the potential of DC2.4 cell line-derived exosomes to induce protective immunity against toxoplasmosis. Our data show that most adoptively transferred T. gondii -pulsed DC-derived exosomes were transferred to the spleen, elicited a strong systemic Th1-modulated Toxoplasma -specific immune response in vivo, and conferred good protection against infection. These findings support the possibility that DC-derived exosomes can be used for T. gondii immunoprophylaxis and for immunoprophylaxis against many other pathogens." @default.
• W2100067495 created "2016-06-24" @default.
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• W2100067495 date "2004-07-01" @default.
• W2100067495 modified "2023-10-18" @default.
• W2100067495 title "<i>Toxoplasma gondii</i>Antigen-Pulsed-Dendritic Cell-Derived Exosomes Induce a Protective Immune Response against<i>T. gondii</i>Infection" @default.
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• W2100067495 doi "https://doi.org/10.1128/iai.72.7.4127-4137.2004" @default.
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