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- W2100068352 abstract "Imprinted genes play crucial roles in mammalian development and disruption of their expression is associated with many human disorders including tumourigenesis; yet, the actual number of imprinted genes in the human genome remains a matter of debate. Here, we report on the unexpected finding that the chromosome 19 microRNA cluster (C19MC), the largest human microRNA gene cluster discovered so far, is regulated by genomic imprinting with only the paternally inherited allele being expressed in the placenta. DNA methylation profiling identified a differentially methylated region (C19MC-DMR1) that overlaps an upstream CpG-rich promoter region associated with short tandem repeats. It displays a maternal-specific methylation imprint acquired in oocytes and generates a complex population of large, compartimentalized non-coding RNA (ncRNA) species retained in close proximity to the C19MC transcription site. This occurs adjacent to, but not within, a poorly characterized nuclear Alu-rich domain. Interestingly, C19MC maps near another imprinted gene, the maternally expressed ZNF331 gene, and therefore may define a novel, previously unrecognized large imprinted primate-specific chromosomal domain. Altogether, our study adds C19MC to the growing list of imprinted repeated small RNA gene clusters and further strengthens the potential involvement of small ncRNAs in the function and/or the evolution of imprinted gene networks." @default.
- W2100068352 created "2016-06-24" @default.
- W2100068352 creator A5011353614 @default.
- W2100068352 creator A5013609746 @default.
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- W2100068352 creator A5029633237 @default.
- W2100068352 creator A5062507730 @default.
- W2100068352 creator A5067751068 @default.
- W2100068352 creator A5088731489 @default.
- W2100068352 date "2010-07-07" @default.
- W2100068352 modified "2023-10-15" @default.
- W2100068352 title "The primate-specific microRNA gene cluster (C19MC) is imprinted in the placenta" @default.
- W2100068352 cites W1502309883 @default.
- W2100068352 cites W1508367671 @default.
- W2100068352 cites W1519061127 @default.
- W2100068352 cites W1754416883 @default.
- W2100068352 cites W1964789204 @default.
- W2100068352 cites W1969606627 @default.
- W2100068352 cites W1970095805 @default.
- W2100068352 cites W1970913370 @default.
- W2100068352 cites W1971647523 @default.
- W2100068352 cites W1976274498 @default.
- W2100068352 cites W1976888700 @default.
- W2100068352 cites W1979225705 @default.
- W2100068352 cites W1980815899 @default.
- W2100068352 cites W1983507216 @default.
- W2100068352 cites W1984948945 @default.
- W2100068352 cites W1986648845 @default.
- W2100068352 cites W1988551012 @default.
- W2100068352 cites W1996521832 @default.
- W2100068352 cites W1997094167 @default.
- W2100068352 cites W1997714925 @default.
- W2100068352 cites W2001206796 @default.
- W2100068352 cites W2001210792 @default.
- W2100068352 cites W2001284661 @default.
- W2100068352 cites W2001766467 @default.
- W2100068352 cites W2002091478 @default.
- W2100068352 cites W2002639317 @default.
- W2100068352 cites W2003288732 @default.
- W2100068352 cites W2003463914 @default.
- W2100068352 cites W2003849576 @default.
- W2100068352 cites W2004280138 @default.
- W2100068352 cites W2004511530 @default.
- W2100068352 cites W2006107100 @default.
- W2100068352 cites W2006498196 @default.
- W2100068352 cites W2006583840 @default.
- W2100068352 cites W2007483233 @default.
- W2100068352 cites W2009920091 @default.
- W2100068352 cites W2015777649 @default.
- W2100068352 cites W2016198323 @default.
- W2100068352 cites W2023373744 @default.
- W2100068352 cites W2023563083 @default.
- W2100068352 cites W2027873015 @default.
- W2100068352 cites W2032393199 @default.
- W2100068352 cites W2036300762 @default.
- W2100068352 cites W2036431960 @default.
- W2100068352 cites W2047713309 @default.
- W2100068352 cites W2049749916 @default.
- W2100068352 cites W2054608914 @default.
- W2100068352 cites W2056865220 @default.
- W2100068352 cites W2059968749 @default.
- W2100068352 cites W2060372899 @default.
- W2100068352 cites W2061441723 @default.
- W2100068352 cites W2063110349 @default.
- W2100068352 cites W2069320956 @default.
- W2100068352 cites W2069408870 @default.
- W2100068352 cites W2071925802 @default.
- W2100068352 cites W2072204610 @default.
- W2100068352 cites W2072380706 @default.
- W2100068352 cites W2074816125 @default.
- W2100068352 cites W2088832142 @default.
- W2100068352 cites W2090796152 @default.
- W2100068352 cites W2091158977 @default.
- W2100068352 cites W2095734937 @default.
- W2100068352 cites W2096226139 @default.
- W2100068352 cites W2096791965 @default.
- W2100068352 cites W2099257978 @default.
- W2100068352 cites W2102400711 @default.
- W2100068352 cites W2103251660 @default.
- W2100068352 cites W2105210592 @default.
- W2100068352 cites W2106909623 @default.
- W2100068352 cites W2119977326 @default.
- W2100068352 cites W2125969407 @default.
- W2100068352 cites W2129299187 @default.
- W2100068352 cites W2130919037 @default.
- W2100068352 cites W2138518792 @default.
- W2100068352 cites W2139480948 @default.
- W2100068352 cites W2141737525 @default.
- W2100068352 cites W2146264881 @default.
- W2100068352 cites W2147835141 @default.
- W2100068352 cites W2149487210 @default.
- W2100068352 cites W2150951264 @default.
- W2100068352 cites W2151051330 @default.
- W2100068352 cites W2152214239 @default.
- W2100068352 cites W2155630480 @default.
- W2100068352 cites W2162246288 @default.
- W2100068352 cites W2163292474 @default.
- W2100068352 cites W2163652992 @default.