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• W2100068521 abstract "Primary blast induced traumatic brain injury (bTBI) is a prevalent battlefield injury in recent conflicts, yet biomechanical mechanisms of bTBI remain unclear. Elucidating specific biomechanical mechanisms is essential to developing animal models for testing candidate therapies and for improving protective equipment. Three hypothetical mechanisms of primary bTBI have received the most attention. Because translational and rotational head accelerations are primary contributors to TBI from non-penetrating blunt force head trauma, the acceleration hypothesis suggests that blast-induced head accelerations may cause bTBI. The hypothesis of direct cranial transmission suggests that a pressure transient traverses the skull into the brain and directly injures brain tissue. The thoracic hypothesis of bTBI suggests that some combination of a pressure transient reaching the brain via the thorax and a vagally mediated reflex result in bTBI. These three mechanisms may not be mutually exclusive, and quantifying exposure thresholds (for blasts of a given duration) is essential for determining which mechanisms may be contributing for a level of blast exposure. Progress has been hindered by experimental designs which do not effectively expose animal models to a single mechanism and by over-reliance on poorly validated computational models. The path forward should be predictive validation of computational models by quantitative confirmation with blast experiments in animal models, human cadavers, and biofidelic human surrogates over a range of relevant blast magnitudes and durations coupled with experimental designs which isolate a single injury mechanism." @default.
• W2100068521 created "2016-06-24" @default.
• W2100068521 creator A5052667856 @default.
• W2100068521 creator A5060095996 @default.
• W2100068521 date "2015-10-19" @default.
• W2100068521 modified "2023-09-27" @default.
• W2100068521 title "The Complexity of Biomechanics Causing Primary Blast-Induced Traumatic Brain Injury: A Review of Potential Mechanisms" @default.
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• W2100068521 doi "https://doi.org/10.3389/fneur.2015.00221" @default.
• W2100068521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4609847" @default.
• W2100068521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26539158" @default.
• W2100068521 hasPublicationYear "2015" @default.
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