Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100069305> ?p ?o ?g. }
- W2100069305 endingPage "3489" @default.
- W2100069305 startingPage "3477" @default.
- W2100069305 abstract "The long-term cellular response to DNA damage is controlled by the tumor suppressor p53. It results in cell-cycle arrest followed by DNA repair and, depending on the degree of damage inflicted, premature senescence or apoptotic cell death. Here we show that in normal diploid fibroblasts the ubiquitin ligase anaphase-promoting complex or cyclosome (APC/C)–Cdh1 becomes prematurely activated in G2 as part of the sustained long-term but not the rapid short-term response to genotoxic stress and results in the degradation of numerous APC/C substrates. Using HCT116 somatic knockout cells we show that mechanistically premature APC/C activation depends on p53 and its transcriptional target p21 that mediates the signal through downregulation of the APC/C inhibitor Emi1. Cdc14B is dispensable in this setting but might function redundantly. Our data suggest an unexpected role for the APC/C in executing a part of the p53-dependent DNA damage response that leads to premature senescence." @default.
- W2100069305 created "2016-06-24" @default.
- W2100069305 creator A5039907115 @default.
- W2100069305 creator A5063858118 @default.
- W2100069305 date "2010-04-12" @default.
- W2100069305 modified "2023-10-09" @default.
- W2100069305 title "p53- and p21-dependent premature APC/C–Cdh1 activation in G2 is part of the long-term response to genotoxic stress" @default.
- W2100069305 cites W1537737236 @default.
- W2100069305 cites W1963842583 @default.
- W2100069305 cites W1963937857 @default.
- W2100069305 cites W1964742508 @default.
- W2100069305 cites W1966121655 @default.
- W2100069305 cites W1967232610 @default.
- W2100069305 cites W1969236463 @default.
- W2100069305 cites W1971936302 @default.
- W2100069305 cites W1974891320 @default.
- W2100069305 cites W1976166089 @default.
- W2100069305 cites W1977052152 @default.
- W2100069305 cites W1979094848 @default.
- W2100069305 cites W1980669461 @default.
- W2100069305 cites W1981401255 @default.
- W2100069305 cites W1982513839 @default.
- W2100069305 cites W1990815825 @default.
- W2100069305 cites W1992686564 @default.
- W2100069305 cites W2005261085 @default.
- W2100069305 cites W2008117987 @default.
- W2100069305 cites W2008751957 @default.
- W2100069305 cites W2009331870 @default.
- W2100069305 cites W2011095025 @default.
- W2100069305 cites W2015141765 @default.
- W2100069305 cites W2026004604 @default.
- W2100069305 cites W2026883897 @default.
- W2100069305 cites W2028361915 @default.
- W2100069305 cites W2035568149 @default.
- W2100069305 cites W2038725955 @default.
- W2100069305 cites W2039412073 @default.
- W2100069305 cites W2048457906 @default.
- W2100069305 cites W2050203263 @default.
- W2100069305 cites W2051663161 @default.
- W2100069305 cites W2057839247 @default.
- W2100069305 cites W2060683430 @default.
- W2100069305 cites W2064256444 @default.
- W2100069305 cites W2065955521 @default.
- W2100069305 cites W2070032322 @default.
- W2100069305 cites W2073494614 @default.
- W2100069305 cites W2075296132 @default.
- W2100069305 cites W2076940668 @default.
- W2100069305 cites W2078441900 @default.
- W2100069305 cites W2079645368 @default.
- W2100069305 cites W2080125477 @default.
- W2100069305 cites W2083450231 @default.
- W2100069305 cites W2086333179 @default.
- W2100069305 cites W2089218510 @default.
- W2100069305 cites W2089964771 @default.
- W2100069305 cites W2099268087 @default.
- W2100069305 cites W2102951681 @default.
- W2100069305 cites W2111837850 @default.
- W2100069305 cites W2114070867 @default.
- W2100069305 cites W2147754598 @default.
- W2100069305 cites W2150945637 @default.
- W2100069305 cites W2151784069 @default.
- W2100069305 cites W2157374362 @default.
- W2100069305 cites W2167732550 @default.
- W2100069305 cites W2169184678 @default.
- W2100069305 doi "https://doi.org/10.1038/onc.2010.99" @default.
- W2100069305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20383190" @default.
- W2100069305 hasPublicationYear "2010" @default.
- W2100069305 type Work @default.
- W2100069305 sameAs 2100069305 @default.
- W2100069305 citedByCount "65" @default.
- W2100069305 countsByYear W21000693052012 @default.
- W2100069305 countsByYear W21000693052013 @default.
- W2100069305 countsByYear W21000693052014 @default.
- W2100069305 countsByYear W21000693052015 @default.
- W2100069305 countsByYear W21000693052016 @default.
- W2100069305 countsByYear W21000693052017 @default.
- W2100069305 countsByYear W21000693052018 @default.
- W2100069305 countsByYear W21000693052019 @default.
- W2100069305 countsByYear W21000693052020 @default.
- W2100069305 countsByYear W21000693052021 @default.
- W2100069305 countsByYear W21000693052022 @default.
- W2100069305 countsByYear W21000693052023 @default.
- W2100069305 crossrefType "journal-article" @default.
- W2100069305 hasAuthorship W2100069305A5039907115 @default.
- W2100069305 hasAuthorship W2100069305A5063858118 @default.
- W2100069305 hasBestOaLocation W21000693051 @default.
- W2100069305 hasConcept C104317684 @default.
- W2100069305 hasConcept C105696609 @default.
- W2100069305 hasConcept C107888121 @default.
- W2100069305 hasConcept C121608353 @default.
- W2100069305 hasConcept C134459356 @default.
- W2100069305 hasConcept C134935766 @default.
- W2100069305 hasConcept C143425029 @default.
- W2100069305 hasConcept C1491633281 @default.
- W2100069305 hasConcept C149402561 @default.
- W2100069305 hasConcept C190283241 @default.
- W2100069305 hasConcept C25602115 @default.
- W2100069305 hasConcept C2776391639 @default.