FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100070554> ?p ?o ?g. }

• W2100070554 endingPage "876" @default.
• W2100070554 startingPage "870" @default.
• W2100070554 abstract "C1-inhibitor deficiency results in bouts of mucocutaneous edema and may be inherited (hereditary angioedema) or acquired (acquired angioedema [AAE]). The two forms have the same clinical picture but differ in the response to treatment. Prophylaxis with antifibrinolytic agents produces better results in the acquired form than in the inherited form, in which androgen derivatives are more effective. It is hypothesized that activation of the contact and fibrinolytic systems is involved in the pathogenesis of attacks. We evaluated these two systems in plasma from eight patients with AAE and anti-C1-inhibitor autoantibodies (autoimmune AAE) by measuring the cleavage of high molecular weight kininogen and the complexes formed by plasmin and its inhibitor alpha 2-antiplasmin. We also measured complement parameters, autoantibody titer, and cleaved C1-inhibitor (relative molecular mass = 96,000), because autoantibodies to C1-inhibitor are known to facilitate its cleavage by proteases. Plasma was obtained from patients in remission, during prophylactic treatment with the antifibrinolytic agent tranexamic acid (2 to 4.5 gm/day) and also from two patients during acute attacks of edema. Levels of cleaved high molecular weight kininogen and antiplasmin-plasmin complexes in patients with AAE were both higher in basal conditions, during treatment, and during acute attacks than those in normal subjects (p < 0.001). The cleaved inactive form of C1-inhibitor was also present in all patients in all three conditions. Therapy with antifibrinolytic agents reduced the frequency and intensity of symptoms without significantly changing any of the biochemical parameters.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2100070554 created "2016-06-24" @default.
• W2100070554 creator A5022485785 @default.
• W2100070554 creator A5050004441 @default.
• W2100070554 creator A5073049397 @default.
• W2100070554 date "1994-05-01" @default.
• W2100070554 modified "2023-09-27" @default.
• W2100070554 title "Activation of the contact system and fibrinolysis in autoimmune acquired angioedema: A rationale for prophylactic use of tranexamic acid" @default.
• W2100070554 cites W11153108 @default.
• W2100070554 cites W1509856372 @default.
• W2100070554 cites W1522956225 @default.
• W2100070554 cites W1568212318 @default.
• W2100070554 cites W1575418040 @default.
• W2100070554 cites W178558460 @default.
• W2100070554 cites W180271278 @default.
• W2100070554 cites W1931895353 @default.
• W2100070554 cites W1969537125 @default.
• W2100070554 cites W1976309347 @default.
• W2100070554 cites W1978596032 @default.
• W2100070554 cites W1978943998 @default.
• W2100070554 cites W1991473086 @default.
• W2100070554 cites W1993990178 @default.
• W2100070554 cites W199796774 @default.
• W2100070554 cites W1999272613 @default.
• W2100070554 cites W2004395480 @default.
• W2100070554 cites W2007064544 @default.
• W2100070554 cites W2012238881 @default.
• W2100070554 cites W2027670269 @default.
• W2100070554 cites W2031123437 @default.
• W2100070554 cites W2034965507 @default.
• W2100070554 cites W2040297666 @default.
• W2100070554 cites W2047011884 @default.
• W2100070554 cites W2052990460 @default.
• W2100070554 cites W2056951481 @default.
• W2100070554 cites W2069700057 @default.
• W2100070554 cites W2070586531 @default.
• W2100070554 cites W2081913575 @default.
• W2100070554 cites W2095237202 @default.
• W2100070554 cites W2105280280 @default.
• W2100070554 cites W2153264508 @default.
• W2100070554 cites W2171583469 @default.
• W2100070554 cites W2269828993 @default.
• W2100070554 cites W2303498974 @default.
• W2100070554 cites W2314295816 @default.
• W2100070554 cites W2325282812 @default.
• W2100070554 cites W2340244022 @default.
• W2100070554 cites W2398932950 @default.
• W2100070554 cites W2417084280 @default.
• W2100070554 cites W2509486 @default.
• W2100070554 cites W44120362 @default.
• W2100070554 cites W2170015070 @default.
• W2100070554 doi "https://doi.org/10.1016/0091-6749(94)90380-8" @default.
• W2100070554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8182230" @default.
• W2100070554 hasPublicationYear "1994" @default.
• W2100070554 type Work @default.
• W2100070554 sameAs 2100070554 @default.
• W2100070554 citedByCount "87" @default.
• W2100070554 countsByYear W21000705542012 @default.
• W2100070554 countsByYear W21000705542013 @default.
• W2100070554 countsByYear W21000705542014 @default.
• W2100070554 countsByYear W21000705542015 @default.
• W2100070554 countsByYear W21000705542016 @default.
• W2100070554 countsByYear W21000705542017 @default.
• W2100070554 countsByYear W21000705542019 @default.
• W2100070554 countsByYear W21000705542020 @default.
• W2100070554 countsByYear W21000705542021 @default.
• W2100070554 countsByYear W21000705542022 @default.
• W2100070554 crossrefType "journal-article" @default.
• W2100070554 hasAuthorship W2100070554A5022485785 @default.
• W2100070554 hasAuthorship W2100070554A5050004441 @default.
• W2100070554 hasAuthorship W2100070554A5073049397 @default.
• W2100070554 hasBestOaLocation W21000705541 @default.
• W2100070554 hasConcept C126322002 @default.
• W2100070554 hasConcept C141071460 @default.
• W2100070554 hasConcept C159654299 @default.
• W2100070554 hasConcept C163764329 @default.
• W2100070554 hasConcept C170493617 @default.
• W2100070554 hasConcept C181199279 @default.
• W2100070554 hasConcept C185592680 @default.
• W2100070554 hasConcept C203014093 @default.
• W2100070554 hasConcept C2776825266 @default.
• W2100070554 hasConcept C2777167447 @default.
• W2100070554 hasConcept C2777788586 @default.
• W2100070554 hasConcept C2777902427 @default.
• W2100070554 hasConcept C2777995640 @default.
• W2100070554 hasConcept C2778382381 @default.
• W2100070554 hasConcept C2779591629 @default.
• W2100070554 hasConcept C2779637338 @default.
• W2100070554 hasConcept C2779931649 @default.
• W2100070554 hasConcept C2780942790 @default.
• W2100070554 hasConcept C2781071845 @default.
• W2100070554 hasConcept C2781219028 @default.
• W2100070554 hasConcept C2781317560 @default.
• W2100070554 hasConcept C2781436528 @default.
• W2100070554 hasConcept C2991743468 @default.
• W2100070554 hasConcept C55493867 @default.
• W2100070554 hasConcept C71924100 @default.
• W2100070554 hasConceptScore W2100070554C126322002 @default.

• next