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- W2100070586 abstract "The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer binding factor) interact with beta-catenin and are hypothesized to mediate Wingless/Wnt signaling. We have cloned a maternally expressed Drosophila TCF family member, dTCF. dTCF binds a canonical TCF DNA motif and interacts with the beta-catenin homolog Armadillo. Previous studies have identified two regions in Armadillo required for Wingless signaling. One of these interacts with dTCF, while the other constitutes a transactivation domain. Mutations in dTCF and expression of a dominant-negative dTCF transgene cause a segment polarity phenotype and affect expression of the Wingless target genes engrailed and Ultrabithorax. Epistasis analysis positions dTCF downstream of armadillo. The Armadillo-dTCF complex mediates Wingless signaling as a bipartite transcription factor." @default.
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- W2100070586 date "1997-03-01" @default.
- W2100070586 modified "2023-10-13" @default.
- W2100070586 title "Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF" @default.
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- W2100070586 doi "https://doi.org/10.1016/s0092-8674(00)81925-x" @default.
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