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- W2100070858 abstract "Aim . In the present study, we investigated the antiangiogenic properties of 59 plants used in traditional Korean medicine. Selected phytochemicals were investigated in more detail for their modes of action. Methods . A modified chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of plant extracts. A molecular docking in silico approached the binding of plant constituents to the vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2). Microarray-based mRNA expression profiling was employed to correlate the 50% inhibition concentrations (IC 50 ) of a panel of 60 NCI cell lines to these phytochemicals. Results . Extracts from Acer mono leaves, Reynoutria sachalniensis fruits, Cinnamomum japonicum stems, Eurya japonica leaves, Adenophora racemosa whole plant, Caryopteris incana leaves-stems, and Schisandra chinensis stems inhibited angiogenesis more than 50% in quail eggs. Selected phytochemicals from Korean plants were analyzed in more detail using microarray-based mRNA expression profiles and molecular docking to VEGFR1 and VEGFR2. These results indicate multifactorial modes of action of these natural products. Conclusion . The antiangiogenic activity of plants used in traditional Korean medicine implicates their possible application for diseases where inhibition of blood vessel formation is desired, for example, cancer, macular degeneration, diabetic retinopathy and others." @default.
- W2100070858 created "2016-06-24" @default.
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- W2100070858 date "2013-01-01" @default.
- W2100070858 modified "2023-10-12" @default.
- W2100070858 title "Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine" @default.
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- W2100070858 cites W196883030 @default.
- W2100070858 cites W1969258395 @default.
- W2100070858 cites W1969903643 @default.
- W2100070858 cites W1970930356 @default.
- W2100070858 cites W1974534243 @default.
- W2100070858 cites W1975490334 @default.
- W2100070858 cites W1982317469 @default.
- W2100070858 cites W1985838900 @default.
- W2100070858 cites W1986550733 @default.
- W2100070858 cites W1988252501 @default.
- W2100070858 cites W1988721753 @default.
- W2100070858 cites W1989312844 @default.
- W2100070858 cites W1992135429 @default.
- W2100070858 cites W1992716708 @default.
- W2100070858 cites W1993494844 @default.
- W2100070858 cites W1993592174 @default.
- W2100070858 cites W1994212736 @default.
- W2100070858 cites W1998901397 @default.
- W2100070858 cites W2000017408 @default.
- W2100070858 cites W2009515507 @default.
- W2100070858 cites W2014961039 @default.
- W2100070858 cites W2015362363 @default.
- W2100070858 cites W2015570273 @default.
- W2100070858 cites W2017640331 @default.
- W2100070858 cites W2018843280 @default.
- W2100070858 cites W2027791116 @default.
- W2100070858 cites W2029992695 @default.
- W2100070858 cites W2030994149 @default.
- W2100070858 cites W2035721941 @default.
- W2100070858 cites W2039220450 @default.
- W2100070858 cites W2041208148 @default.
- W2100070858 cites W2046603236 @default.
- W2100070858 cites W2048380602 @default.
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- W2100070858 cites W2072955490 @default.
- W2100070858 cites W2075084939 @default.
- W2100070858 cites W2086916208 @default.
- W2100070858 cites W2088694924 @default.
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- W2100070858 doi "https://doi.org/10.1155/2013/131306" @default.
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