Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100071228> ?p ?o ?g. }
- W2100071228 endingPage "1091" @default.
- W2100071228 startingPage "1081" @default.
- W2100071228 abstract "Kinesin-5 is a homotetrameric motor protein that interacts with adjacent microtubules in the mitotic spindle. Kinesin-5 is also highly expressed in developing postmitotic neurons. Axons of cultured neurons experimentally depleted of kinesin-5 grow up to five times longer than controls and display more branches. The faster growth rates are accompanied by a doubling of the frequency of transport of short microtubules, suggesting a major role for kinesin-5 in the balance of motor-driven forces on the axonal microtubule array. Live-cell imaging reveals that the effects on axonal length of kinesin-5 depletion are caused partly by a lower propensity of the axon and newly forming branches to undergo bouts of retraction. Overexpression of wild-type kinesin-5, but not a rigor mutant of kinesin-5, has the inverse effect on axonal length. These results indicate that kinesin-5 imposes restrictions on the growth of the axon and does so at least in part by generating forces on the axonal microtubule array." @default.
- W2100071228 created "2016-06-24" @default.
- W2100071228 creator A5040520845 @default.
- W2100071228 creator A5072020119 @default.
- W2100071228 date "2007-09-10" @default.
- W2100071228 modified "2023-10-10" @default.
- W2100071228 title "Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array" @default.
- W2100071228 cites W130267474 @default.
- W2100071228 cites W1554595041 @default.
- W2100071228 cites W1554750796 @default.
- W2100071228 cites W1566067132 @default.
- W2100071228 cites W1606745417 @default.
- W2100071228 cites W1647008873 @default.
- W2100071228 cites W1965044075 @default.
- W2100071228 cites W1966881434 @default.
- W2100071228 cites W1977087532 @default.
- W2100071228 cites W1977666960 @default.
- W2100071228 cites W1981270258 @default.
- W2100071228 cites W1981973341 @default.
- W2100071228 cites W1985701763 @default.
- W2100071228 cites W1988678729 @default.
- W2100071228 cites W2001978459 @default.
- W2100071228 cites W2004059254 @default.
- W2100071228 cites W2006876135 @default.
- W2100071228 cites W2015297120 @default.
- W2100071228 cites W2017760953 @default.
- W2100071228 cites W2029268455 @default.
- W2100071228 cites W2041060940 @default.
- W2100071228 cites W2046320664 @default.
- W2100071228 cites W2064516399 @default.
- W2100071228 cites W2084049913 @default.
- W2100071228 cites W2085102956 @default.
- W2100071228 cites W2089340266 @default.
- W2100071228 cites W2102160332 @default.
- W2100071228 cites W2102247077 @default.
- W2100071228 cites W2107673711 @default.
- W2100071228 cites W2108422673 @default.
- W2100071228 cites W2112064082 @default.
- W2100071228 cites W2115777487 @default.
- W2100071228 cites W2117196140 @default.
- W2100071228 cites W2117610604 @default.
- W2100071228 cites W2133492742 @default.
- W2100071228 cites W2134558913 @default.
- W2100071228 cites W2143997493 @default.
- W2100071228 cites W2146314877 @default.
- W2100071228 cites W2146640900 @default.
- W2100071228 cites W2149762749 @default.
- W2100071228 cites W2154782261 @default.
- W2100071228 cites W2162800498 @default.
- W2100071228 doi "https://doi.org/10.1083/jcb.200702074" @default.
- W2100071228 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064629" @default.
- W2100071228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17846176" @default.
- W2100071228 hasPublicationYear "2007" @default.
- W2100071228 type Work @default.
- W2100071228 sameAs 2100071228 @default.
- W2100071228 citedByCount "145" @default.
- W2100071228 countsByYear W21000712282012 @default.
- W2100071228 countsByYear W21000712282013 @default.
- W2100071228 countsByYear W21000712282014 @default.
- W2100071228 countsByYear W21000712282015 @default.
- W2100071228 countsByYear W21000712282016 @default.
- W2100071228 countsByYear W21000712282017 @default.
- W2100071228 countsByYear W21000712282018 @default.
- W2100071228 countsByYear W21000712282019 @default.
- W2100071228 countsByYear W21000712282020 @default.
- W2100071228 countsByYear W21000712282021 @default.
- W2100071228 countsByYear W21000712282022 @default.
- W2100071228 countsByYear W21000712282023 @default.
- W2100071228 crossrefType "journal-article" @default.
- W2100071228 hasAuthorship W2100071228A5040520845 @default.
- W2100071228 hasAuthorship W2100071228A5072020119 @default.
- W2100071228 hasBestOaLocation W21000712281 @default.
- W2100071228 hasConcept C10447061 @default.
- W2100071228 hasConcept C1491633281 @default.
- W2100071228 hasConcept C20418707 @default.
- W2100071228 hasConcept C2779530196 @default.
- W2100071228 hasConcept C29537977 @default.
- W2100071228 hasConcept C55493867 @default.
- W2100071228 hasConcept C59006786 @default.
- W2100071228 hasConcept C70192387 @default.
- W2100071228 hasConcept C86803240 @default.
- W2100071228 hasConcept C93126451 @default.
- W2100071228 hasConcept C93304396 @default.
- W2100071228 hasConcept C94921385 @default.
- W2100071228 hasConcept C95444343 @default.
- W2100071228 hasConceptScore W2100071228C10447061 @default.
- W2100071228 hasConceptScore W2100071228C1491633281 @default.
- W2100071228 hasConceptScore W2100071228C20418707 @default.
- W2100071228 hasConceptScore W2100071228C2779530196 @default.
- W2100071228 hasConceptScore W2100071228C29537977 @default.
- W2100071228 hasConceptScore W2100071228C55493867 @default.
- W2100071228 hasConceptScore W2100071228C59006786 @default.
- W2100071228 hasConceptScore W2100071228C70192387 @default.
- W2100071228 hasConceptScore W2100071228C86803240 @default.
- W2100071228 hasConceptScore W2100071228C93126451 @default.
- W2100071228 hasConceptScore W2100071228C93304396 @default.
- W2100071228 hasConceptScore W2100071228C94921385 @default.
- W2100071228 hasConceptScore W2100071228C95444343 @default.