FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100071994> ?p ?o ?g. }

• W2100071994 endingPage "645" @default.
• W2100071994 startingPage "635" @default.
• W2100071994 abstract "Biochemical data have shown that COPI-coated vesicles are tethered to Golgi membranes by a complex of at least three proteins: p115, giantin, and GM130. p115 binds to giantin on the vesicles and to GM130 on the membrane. We now examine the function of this tethering complex in vivo. Microinjection of an N-terminal peptide of GM130 or overexpression of GM130 lacking this N-terminal peptide inhibits the binding of p115 to Golgi membranes. Electron microscopic analysis of single microinjected cells shows that the number of COP-sized transport vesicles in the Golgi region increases substantially, suggesting that transport vesicles continue to bud but are less able to fuse. This was corroborated by quantitative immunofluorescence analysis, which showed that the intracellular transport of the VSV-G protein was significantly inhibited. Together, these data suggest that this tethering complex increases the efficiency with which transport vesicles fuse with their target membrane. They also provide support for a model of mitotic Golgi fragmentation in which the tethering complex is disrupted by mitotic phosphorylation of GM130." @default.
• W2100071994 created "2016-06-24" @default.
• W2100071994 creator A5007270321 @default.
• W2100071994 creator A5027298281 @default.
• W2100071994 creator A5073719453 @default.
• W2100071994 date "2000-02-01" @default.
• W2100071994 modified "2023-10-16" @default.
• W2100071994 title "The Role of the Tethering Proteins p115 and GM130 in Transport through the Golgi Apparatus In Vivo" @default.
• W2100071994 cites W1490634802 @default.
• W2100071994 cites W1502422391 @default.
• W2100071994 cites W1508614407 @default.
• W2100071994 cites W1516919274 @default.
• W2100071994 cites W1552784036 @default.
• W2100071994 cites W1556110303 @default.
• W2100071994 cites W1595436183 @default.
• W2100071994 cites W1779491042 @default.
• W2100071994 cites W1963912518 @default.
• W2100071994 cites W1972510078 @default.
• W2100071994 cites W1982922156 @default.
• W2100071994 cites W1997662437 @default.
• W2100071994 cites W1999127875 @default.
• W2100071994 cites W2000647007 @default.
• W2100071994 cites W2002426370 @default.
• W2100071994 cites W2006287134 @default.
• W2100071994 cites W2007296924 @default.
• W2100071994 cites W2007629131 @default.
• W2100071994 cites W2008429193 @default.
• W2100071994 cites W2009644279 @default.
• W2100071994 cites W2012756328 @default.
• W2100071994 cites W2013654291 @default.
• W2100071994 cites W2016266703 @default.
• W2100071994 cites W2017239021 @default.
• W2100071994 cites W2017886031 @default.
• W2100071994 cites W2021272662 @default.
• W2100071994 cites W2022772974 @default.
• W2100071994 cites W2027775552 @default.
• W2100071994 cites W2029152767 @default.
• W2100071994 cites W2029327566 @default.
• W2100071994 cites W2038882113 @default.
• W2100071994 cites W2041073272 @default.
• W2100071994 cites W2050199375 @default.
• W2100071994 cites W2058738603 @default.
• W2100071994 cites W2065687264 @default.
• W2100071994 cites W2066055881 @default.
• W2100071994 cites W2071572433 @default.
• W2100071994 cites W2071629435 @default.
• W2100071994 cites W2084456466 @default.
• W2100071994 cites W2085490483 @default.
• W2100071994 cites W2085680244 @default.
• W2100071994 cites W2092521820 @default.
• W2100071994 cites W2094104389 @default.
• W2100071994 cites W2096168820 @default.
• W2100071994 cites W2102948276 @default.
• W2100071994 cites W2113439078 @default.
• W2100071994 cites W2114356820 @default.
• W2100071994 cites W2119441048 @default.
• W2100071994 cites W2120636641 @default.
• W2100071994 cites W2126162952 @default.
• W2100071994 cites W2128888716 @default.
• W2100071994 cites W2131879548 @default.
• W2100071994 cites W2136822273 @default.
• W2100071994 cites W2141799366 @default.
• W2100071994 cites W2146318484 @default.
• W2100071994 cites W2152791827 @default.
• W2100071994 cites W2156520020 @default.
• W2100071994 cites W2166247822 @default.
• W2100071994 cites W2179777589 @default.
• W2100071994 cites W2186139098 @default.
• W2100071994 doi "https://doi.org/10.1091/mbc.11.2.635" @default.
• W2100071994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/14799" @default.
• W2100071994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10679020" @default.
• W2100071994 hasPublicationYear "2000" @default.
• W2100071994 type Work @default.
• W2100071994 sameAs 2100071994 @default.
• W2100071994 citedByCount "169" @default.
• W2100071994 countsByYear W21000719942012 @default.
• W2100071994 countsByYear W21000719942013 @default.
• W2100071994 countsByYear W21000719942014 @default.
• W2100071994 countsByYear W21000719942015 @default.
• W2100071994 countsByYear W21000719942016 @default.
• W2100071994 countsByYear W21000719942017 @default.
• W2100071994 countsByYear W21000719942018 @default.
• W2100071994 countsByYear W21000719942019 @default.
• W2100071994 countsByYear W21000719942020 @default.
• W2100071994 countsByYear W21000719942021 @default.
• W2100071994 countsByYear W21000719942022 @default.
• W2100071994 countsByYear W21000719942023 @default.
• W2100071994 crossrefType "journal-article" @default.
• W2100071994 hasAuthorship W2100071994A5007270321 @default.
• W2100071994 hasAuthorship W2100071994A5027298281 @default.
• W2100071994 hasAuthorship W2100071994A5073719453 @default.
• W2100071994 hasBestOaLocation W21000719942 @default.
• W2100071994 hasConcept C102747710 @default.
• W2100071994 hasConcept C119062480 @default.
• W2100071994 hasConcept C130316041 @default.
• W2100071994 hasConcept C158617107 @default.
• W2100071994 hasConcept C201815810 @default.
• W2100071994 hasConcept C206912223 @default.

• next