FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100072170> ?p ?o ?g. }

• W2100072170 endingPage "913" @default.
• W2100072170 startingPage "909" @default.
• W2100072170 abstract "Prepulse inhibition (PPI) is thought to reflect the operation of a sensorimotor gating system in the brain. Sensorimotor gating abnormalities have been identified in schizophrenic patients, and various neural systems are involved in this function. To study the modulation of the sensorimotor gating system by the N-methyl-D-aspartate (NMDA) receptor channel complex, the effects of noncompetitive and competitive NMDA antagonists on PPI were examined in rats. PPI was not disrupted by CGS 19755, a competitive NMDA antagonist, at 30 min after subcutaneous (s.c.) administration. However, CGS 19755 (40 mg/kg s.c.) decreased PPI at 120 min after administration with a marked decrease of startle amplitude. Late onset of the effect of CGS 19755 was also observed in the increase of spontaneous locomotor activity (SLA). On the other hand, phencyclidine, a noncompetitive NMDA antagonist, disrupted PPI at 30 min after administration and increased SLA from 20 min after administration. PPI was also disrupted by bilateral intracerebroventricular administration of 5,7-dichlorokyn urenate (10 and 20 micrograms/side X 2), an antagonist at the strychnine-insensitive glycine receptor, which is an allosteric binding site in the NMDA receptor-channel complex. It is concluded that the NMDA receptor-channel complex plays an important role in regulation of PPI." @default.
• W2100072170 created "2016-06-24" @default.
• W2100072170 creator A5022989688 @default.
• W2100072170 creator A5045762882 @default.
• W2100072170 date "1997-08-01" @default.
• W2100072170 modified "2023-10-18" @default.
• W2100072170 title "Competitive NMDA and Strychnine-Insensitive Glycine-Site Antagonists Disrupt Prepulse Inhibition" @default.
• W2100072170 cites W1965317964 @default.
• W2100072170 cites W1966051646 @default.
• W2100072170 cites W1972895831 @default.
• W2100072170 cites W1973947372 @default.
• W2100072170 cites W1976772152 @default.
• W2100072170 cites W1980967004 @default.
• W2100072170 cites W1986859027 @default.
• W2100072170 cites W1988836643 @default.
• W2100072170 cites W1990888488 @default.
• W2100072170 cites W1992625143 @default.
• W2100072170 cites W1997038668 @default.
• W2100072170 cites W1998141074 @default.
• W2100072170 cites W2000297725 @default.
• W2100072170 cites W2004955930 @default.
• W2100072170 cites W2009134635 @default.
• W2100072170 cites W2022183380 @default.
• W2100072170 cites W2024326543 @default.
• W2100072170 cites W2041153769 @default.
• W2100072170 cites W2047172896 @default.
• W2100072170 cites W2050814939 @default.
• W2100072170 cites W2052815900 @default.
• W2100072170 cites W2071529758 @default.
• W2100072170 cites W2079730191 @default.
• W2100072170 cites W2084960545 @default.
• W2100072170 cites W2094450187 @default.
• W2100072170 cites W2097759310 @default.
• W2100072170 cites W2124389210 @default.
• W2100072170 doi "https://doi.org/10.1016/s0091-3057(96)00452-2" @default.
• W2100072170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9259023" @default.
• W2100072170 hasPublicationYear "1997" @default.
• W2100072170 type Work @default.
• W2100072170 sameAs 2100072170 @default.
• W2100072170 citedByCount "20" @default.
• W2100072170 countsByYear W21000721702017 @default.
• W2100072170 crossrefType "journal-article" @default.
• W2100072170 hasAuthorship W2100072170A5022989688 @default.
• W2100072170 hasAuthorship W2100072170A5045762882 @default.
• W2100072170 hasConcept C118552586 @default.
• W2100072170 hasConcept C141421786 @default.
• W2100072170 hasConcept C15744967 @default.
• W2100072170 hasConcept C166342909 @default.
• W2100072170 hasConcept C169760540 @default.
• W2100072170 hasConcept C170493617 @default.
• W2100072170 hasConcept C185592680 @default.
• W2100072170 hasConcept C194544171 @default.
• W2100072170 hasConcept C2776412080 @default.
• W2100072170 hasConcept C2776885963 @default.
• W2100072170 hasConcept C2777725853 @default.
• W2100072170 hasConcept C2777756961 @default.
• W2100072170 hasConcept C2777836312 @default.
• W2100072170 hasConcept C2778851735 @default.
• W2100072170 hasConcept C35599011 @default.
• W2100072170 hasConcept C515207424 @default.
• W2100072170 hasConcept C55493867 @default.
• W2100072170 hasConcept C67018056 @default.
• W2100072170 hasConcept C71924100 @default.
• W2100072170 hasConcept C86811712 @default.
• W2100072170 hasConcept C98274493 @default.
• W2100072170 hasConceptScore W2100072170C118552586 @default.
• W2100072170 hasConceptScore W2100072170C141421786 @default.
• W2100072170 hasConceptScore W2100072170C15744967 @default.
• W2100072170 hasConceptScore W2100072170C166342909 @default.
• W2100072170 hasConceptScore W2100072170C169760540 @default.
• W2100072170 hasConceptScore W2100072170C170493617 @default.
• W2100072170 hasConceptScore W2100072170C185592680 @default.
• W2100072170 hasConceptScore W2100072170C194544171 @default.
• W2100072170 hasConceptScore W2100072170C2776412080 @default.
• W2100072170 hasConceptScore W2100072170C2776885963 @default.
• W2100072170 hasConceptScore W2100072170C2777725853 @default.
• W2100072170 hasConceptScore W2100072170C2777756961 @default.
• W2100072170 hasConceptScore W2100072170C2777836312 @default.
• W2100072170 hasConceptScore W2100072170C2778851735 @default.
• W2100072170 hasConceptScore W2100072170C35599011 @default.
• W2100072170 hasConceptScore W2100072170C515207424 @default.
• W2100072170 hasConceptScore W2100072170C55493867 @default.
• W2100072170 hasConceptScore W2100072170C67018056 @default.
• W2100072170 hasConceptScore W2100072170C71924100 @default.
• W2100072170 hasConceptScore W2100072170C86811712 @default.
• W2100072170 hasConceptScore W2100072170C98274493 @default.
• W2100072170 hasIssue "4" @default.
• W2100072170 hasLocation W21000721701 @default.
• W2100072170 hasLocation W21000721702 @default.
• W2100072170 hasOpenAccess W2100072170 @default.
• W2100072170 hasPrimaryLocation W21000721701 @default.
• W2100072170 hasRelatedWork W1870944445 @default.
• W2100072170 hasRelatedWork W1982595715 @default.
• W2100072170 hasRelatedWork W2000375438 @default.
• W2100072170 hasRelatedWork W2009121340 @default.
• W2100072170 hasRelatedWork W2028568597 @default.
• W2100072170 hasRelatedWork W2030886494 @default.
• W2100072170 hasRelatedWork W2073343486 @default.

• next