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• W2100074740 abstract "To our knowledge, the problem of how to maintain isolated smooth cells in a “contractile” phenotypic state without deviation after subculturing has yet to be resolved. The present study characterized the in vitro contractile response of human uterine smooth muscle cell to endothelin-1, which induces contractions in isolated uterine strips. Contractile effects were qualitatively investigated using silicone rubber substrata. Endothelin-1 was able to distort and reduce the wrinkles in the silicone surface. Contractions were also quantified by measuring the resulting change in the collagen lattice area. Endothelin-1 significantly increased the contractile response in a dose-dependent manner by selectively activating endothelin A receptors. When myometrial cells were cultured within collagen lattices, a microfilament-disrupting agent, cytochalasin B, abolished contractions, and no change was observed in smooth muscle α-actin immunostaining. Taken together, these observations show that the uterine smooth muscle cells are contractile and respond appropriately to a potent uterotonic agent. Based on these findings, a cultured uterine smooth muscle cell model, which could be used to elucidate the mechanisms controlling uterine activity, is proposed." @default.
• W2100074740 created "2016-06-24" @default.
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• W2100074740 date "2003-03-01" @default.
• W2100074740 modified "2023-10-18" @default.
• W2100074740 title "Contraction of Cultured Human Uterine Smooth Muscle Cells after Stimulation with Endothelin-1" @default.
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• W2100074740 doi "https://doi.org/10.1095/biolreprod.102.008367" @default.
• W2100074740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12604645" @default.
• W2100074740 hasPublicationYear "2003" @default.
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