Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100076933> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2100076933 endingPage "1595" @default.
- W2100076933 startingPage "1589" @default.
- W2100076933 abstract "Despite long use of protamine in cardiac operations, neither protamine concentrations nor pharmacokinetics have been reported in patients.Twenty-eight patients (age, 26 to 80 years) undergoing various cardiac surgical procedures gave their consent to receive 250 mg of protamine sulfate administered intravenously by an infusion pump during 5 minutes. Protamine was administered at the usual intraoperative time after separation from cardiopulmonary bypass for reversal of heparin. Timed arterial blood samples were obtained after protamine infusion. Blood plasma was subjected to solid-phase extraction and high-performance liquid chromatography. Total (free + heparin-bound) protamine concentration versus time data were subjected to pharmacokinetic modeling.Twenty-six patients completed the study. Total plasma protamine concentrations declined rapidly. Model-independent pharmacokinetic analysis revealed median (range) values as follows: volume of distribution, 5.4 L (0.82 to 34 L); clearance, 1.4 L/min (0.61 to 3.8 L/min); and half-life, 4.5 min (1.9 to 18 min). Schwarz-Bayesian criterion identified a two-compartment exponential model with adjustment for weight in the central compartment volume of distribution as performing better than other compartmental or Michaelis-Menten models.Protamine has a very short (approximately 5 minutes) half-life after a single 250-mg dose in adult patients. This short half-life could underlie recurrent anticoagulation after initial apparent reversal of heparin." @default.
- W2100076933 created "2016-06-24" @default.
- W2100076933 creator A5008737075 @default.
- W2100076933 creator A5017000834 @default.
- W2100076933 creator A5040611335 @default.
- W2100076933 creator A5047167528 @default.
- W2100076933 creator A5071588829 @default.
- W2100076933 creator A5086479943 @default.
- W2100076933 date "2002-11-01" @default.
- W2100076933 modified "2023-10-15" @default.
- W2100076933 title "Rapid disappearance of protamine in adults undergoing cardiac operation with cardiopulmonary bypass" @default.
- W2100076933 cites W2015532596 @default.
- W2100076933 cites W2015717200 @default.
- W2100076933 cites W2041360291 @default.
- W2100076933 cites W2069322946 @default.
- W2100076933 cites W2085793556 @default.
- W2100076933 cites W2091242480 @default.
- W2100076933 cites W2096787136 @default.
- W2100076933 cites W2103672776 @default.
- W2100076933 cites W2130643869 @default.
- W2100076933 cites W2149035170 @default.
- W2100076933 cites W2155007797 @default.
- W2100076933 cites W2437047154 @default.
- W2100076933 cites W4235539822 @default.
- W2100076933 cites W4237925698 @default.
- W2100076933 doi "https://doi.org/10.1016/s0003-4975(02)04016-x" @default.
- W2100076933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12440613" @default.
- W2100076933 hasPublicationYear "2002" @default.
- W2100076933 type Work @default.
- W2100076933 sameAs 2100076933 @default.
- W2100076933 citedByCount "71" @default.
- W2100076933 countsByYear W21000769332012 @default.
- W2100076933 countsByYear W21000769332013 @default.
- W2100076933 countsByYear W21000769332014 @default.
- W2100076933 countsByYear W21000769332015 @default.
- W2100076933 countsByYear W21000769332016 @default.
- W2100076933 countsByYear W21000769332017 @default.
- W2100076933 countsByYear W21000769332018 @default.
- W2100076933 countsByYear W21000769332019 @default.
- W2100076933 countsByYear W21000769332020 @default.
- W2100076933 countsByYear W21000769332021 @default.
- W2100076933 countsByYear W21000769332022 @default.
- W2100076933 countsByYear W21000769332023 @default.
- W2100076933 crossrefType "journal-article" @default.
- W2100076933 hasAuthorship W2100076933A5008737075 @default.
- W2100076933 hasAuthorship W2100076933A5017000834 @default.
- W2100076933 hasAuthorship W2100076933A5040611335 @default.
- W2100076933 hasAuthorship W2100076933A5047167528 @default.
- W2100076933 hasAuthorship W2100076933A5071588829 @default.
- W2100076933 hasAuthorship W2100076933A5086479943 @default.
- W2100076933 hasBestOaLocation W21000769331 @default.
- W2100076933 hasConcept C112705442 @default.
- W2100076933 hasConcept C139254425 @default.
- W2100076933 hasConcept C141071460 @default.
- W2100076933 hasConcept C2777557582 @default.
- W2100076933 hasConcept C2778881276 @default.
- W2100076933 hasConcept C2779354726 @default.
- W2100076933 hasConcept C2780835560 @default.
- W2100076933 hasConcept C3941253 @default.
- W2100076933 hasConcept C42219234 @default.
- W2100076933 hasConcept C71924100 @default.
- W2100076933 hasConcept C98274493 @default.
- W2100076933 hasConceptScore W2100076933C112705442 @default.
- W2100076933 hasConceptScore W2100076933C139254425 @default.
- W2100076933 hasConceptScore W2100076933C141071460 @default.
- W2100076933 hasConceptScore W2100076933C2777557582 @default.
- W2100076933 hasConceptScore W2100076933C2778881276 @default.
- W2100076933 hasConceptScore W2100076933C2779354726 @default.
- W2100076933 hasConceptScore W2100076933C2780835560 @default.
- W2100076933 hasConceptScore W2100076933C3941253 @default.
- W2100076933 hasConceptScore W2100076933C42219234 @default.
- W2100076933 hasConceptScore W2100076933C71924100 @default.
- W2100076933 hasConceptScore W2100076933C98274493 @default.
- W2100076933 hasIssue "5" @default.
- W2100076933 hasLocation W21000769331 @default.
- W2100076933 hasLocation W21000769332 @default.
- W2100076933 hasOpenAccess W2100076933 @default.
- W2100076933 hasPrimaryLocation W21000769331 @default.
- W2100076933 hasRelatedWork W108228781 @default.
- W2100076933 hasRelatedWork W206436102 @default.
- W2100076933 hasRelatedWork W2100076933 @default.
- W2100076933 hasRelatedWork W2131244057 @default.
- W2100076933 hasRelatedWork W2412783951 @default.
- W2100076933 hasRelatedWork W3080585104 @default.
- W2100076933 hasRelatedWork W3086740988 @default.
- W2100076933 hasRelatedWork W4223647064 @default.
- W2100076933 hasRelatedWork W4250826754 @default.
- W2100076933 hasRelatedWork W2049455104 @default.
- W2100076933 hasVolume "74" @default.
- W2100076933 isParatext "false" @default.
- W2100076933 isRetracted "false" @default.
- W2100076933 magId "2100076933" @default.
- W2100076933 workType "article" @default.