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- W2100078032 abstract "Abstract A study of the effectiveness of a phytonadione (vitamin K 1 ) colloidal suspension in reducing the elevated prothrombin times of bishydroxy-coumarin-treated patients was performed. Prothrombin times were studied two, four, six, eight and twenty-four hours after the administering to groups of ten patients each, of 10 mg. of the phytonadione intravenously, intramuscularly and subcutaneously, as well as after administering 5 mg. intravenously. The 10 mg. dose given intravenously showed a statistically significant acceleration of the return of the elevated prothrombin times toward normal as compared to a control group of eight patients similarly studied. This effect was observed at two hours and was greatest four hours after the vitamin was given. The 10 mg. subcutaneous dose and the 5 mg. intravenous dose failed to accelerate the return of the prothrombin times toward normal. The 10 mg. dose given intramuscularly showed some effect after twenty-four hours, but this could not be proved statistically significant. Using the 50 per cent prothrombin time value as the index of a return to a normal coagulation mechanism, four out of the group of ten patients given 10 mg. intravenously failed to reach this value. Nine bleeding episodes secondary to bishydroxycoumarin therapy were treated. Seven patients receiving 10 mg. intravenously and one who received 10 mg. subcutaneously stopped their bleeding in six to twenty-four hours after treatment. The one patient who received 5 mg. intravenously continued to bleed until a second dose of 10 mg. was given intravenously." @default.
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- W2100078032 date "1961-07-01" @default.
- W2100078032 modified "2023-09-27" @default.
- W2100078032 title "Colloidally suspended phytonadione in bishydroxycoumarin-induced hypoprothrombinemia" @default.
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- W2100078032 doi "https://doi.org/10.1016/0002-9149(61)90180-1" @default.
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