FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100078332> ?p ?o ?g. }

• W2100078332 endingPage "7914" @default.
• W2100078332 startingPage "7907" @default.
• W2100078332 abstract "Hypoxia is a common phenomenon in prostate cancer, which leads to cell proliferation and tumor growth. Fractalkine (FKN) is a membrane‑bound chemokine, which is implicated in the progression of human prostate cancer and skeletal metastasis. However, the association between FKN and hypoxia‑induced prostate cancer cell proliferation remains to be elucidated. The present study demonstrated that hypoxia induced the expression and secretion of FKN in the DU145 prostate cancer cell line. Furthermore, inhibiting the activity of FKN with the anti‑FKN FKN‑specific antibody markedly inhibited hypoxia‑induced DU145 cell proliferation. Under normoxic conditions, DU145 cell proliferation markedly increased following exogenous administration of human recombinant FKN protein, and the increase was significantly alleviated by anti‑FKN, indicating the importance of FKN in DU145 cell proliferation. In addition, subsequent determination of cell cycle distribution and expression levels of two core cell cycle regulators, cyclin E and cyclin‑dependent kinase (CDK)2, suggested that FKN promoted the G1/S phase transition by upregulating the expression levels of cyclin E and CDK2. The results of the present study demonstrated that hypoxia led to the upregulation of the secretion and expression of FKN, which enhanced cell proliferation by promoting cell cycle progression in the prostate cancer cells. These findings provide evidence of a novel function for FKN, and suggest that FKN may serve as a potential target for treating androgen‑independent prostate cancer." @default.
• W2100078332 created "2016-06-24" @default.
• W2100078332 creator A5006063221 @default.
• W2100078332 creator A5011125054 @default.
• W2100078332 creator A5014845250 @default.
• W2100078332 creator A5026702959 @default.
• W2100078332 creator A5050471394 @default.
• W2100078332 creator A5056036725 @default.
• W2100078332 creator A5063772620 @default.
• W2100078332 creator A5074160086 @default.
• W2100078332 creator A5079424962 @default.
• W2100078332 creator A5089916595 @default.
• W2100078332 date "2015-10-13" @default.
• W2100078332 modified "2023-10-14" @default.
• W2100078332 title "Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition" @default.
• W2100078332 cites W1492343502 @default.
• W2100078332 cites W1971056409 @default.
• W2100078332 cites W1979928115 @default.
• W2100078332 cites W1981989535 @default.
• W2100078332 cites W1984115097 @default.
• W2100078332 cites W1984434438 @default.
• W2100078332 cites W1988335934 @default.
• W2100078332 cites W2005658600 @default.
• W2100078332 cites W2020385479 @default.
• W2100078332 cites W2021505095 @default.
• W2100078332 cites W2030917941 @default.
• W2100078332 cites W2047835935 @default.
• W2100078332 cites W2059858274 @default.
• W2100078332 cites W2070186254 @default.
• W2100078332 cites W2093425397 @default.
• W2100078332 cites W2094000075 @default.
• W2100078332 cites W2095382438 @default.
• W2100078332 cites W2098688328 @default.
• W2100078332 cites W2102884387 @default.
• W2100078332 cites W2105207870 @default.
• W2100078332 cites W2107241547 @default.
• W2100078332 cites W2114259322 @default.
• W2100078332 cites W2116042273 @default.
• W2100078332 cites W2123553801 @default.
• W2100078332 cites W2124984983 @default.
• W2100078332 cites W2128629090 @default.
• W2100078332 cites W2139050844 @default.
• W2100078332 cites W2140367399 @default.
• W2100078332 cites W2141406535 @default.
• W2100078332 cites W2142307660 @default.
• W2100078332 cites W2152770189 @default.
• W2100078332 cites W2162245431 @default.
• W2100078332 cites W2162654432 @default.
• W2100078332 cites W2167111449 @default.
• W2100078332 cites W2169961966 @default.
• W2100078332 cites W2171852242 @default.
• W2100078332 cites W2219978888 @default.
• W2100078332 cites W2419585983 @default.
• W2100078332 cites W2526890 @default.
• W2100078332 cites W26434078 @default.
• W2100078332 doi "https://doi.org/10.3892/mmr.2015.4438" @default.
• W2100078332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4758273" @default.
• W2100078332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26496926" @default.
• W2100078332 hasPublicationYear "2015" @default.
• W2100078332 type Work @default.
• W2100078332 sameAs 2100078332 @default.
• W2100078332 citedByCount "17" @default.
• W2100078332 countsByYear W21000783322016 @default.
• W2100078332 countsByYear W21000783322017 @default.
• W2100078332 countsByYear W21000783322018 @default.
• W2100078332 countsByYear W21000783322020 @default.
• W2100078332 countsByYear W21000783322021 @default.
• W2100078332 countsByYear W21000783322022 @default.
• W2100078332 countsByYear W21000783322023 @default.
• W2100078332 crossrefType "journal-article" @default.
• W2100078332 hasAuthorship W2100078332A5006063221 @default.
• W2100078332 hasAuthorship W2100078332A5011125054 @default.
• W2100078332 hasAuthorship W2100078332A5014845250 @default.
• W2100078332 hasAuthorship W2100078332A5026702959 @default.
• W2100078332 hasAuthorship W2100078332A5050471394 @default.
• W2100078332 hasAuthorship W2100078332A5056036725 @default.
• W2100078332 hasAuthorship W2100078332A5063772620 @default.
• W2100078332 hasAuthorship W2100078332A5074160086 @default.
• W2100078332 hasAuthorship W2100078332A5079424962 @default.
• W2100078332 hasAuthorship W2100078332A5089916595 @default.
• W2100078332 hasBestOaLocation W21000783321 @default.
• W2100078332 hasConcept C104317684 @default.
• W2100078332 hasConcept C121608353 @default.
• W2100078332 hasConcept C126322002 @default.
• W2100078332 hasConcept C127561419 @default.
• W2100078332 hasConcept C1491633281 @default.
• W2100078332 hasConcept C2776438761 @default.
• W2100078332 hasConcept C2779723316 @default.
• W2100078332 hasConcept C2780192828 @default.
• W2100078332 hasConcept C29537977 @default.
• W2100078332 hasConcept C502942594 @default.
• W2100078332 hasConcept C54355233 @default.
• W2100078332 hasConcept C55493867 @default.
• W2100078332 hasConcept C62112901 @default.
• W2100078332 hasConcept C71924100 @default.
• W2100078332 hasConcept C86803240 @default.
• W2100078332 hasConcept C96232424 @default.
• W2100078332 hasConceptScore W2100078332C104317684 @default.

• next