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- W2100078415 abstract "Recombinant bacterial lipoproteins (RLP) with built-in immuno-stimulating properties for novel subunit vaccine development are reviewed. This platform technology offers the following advantages: easily converts antigens into highly immunogenic RLP using a fusion sequence containing lipobox; the lipid moiety of RLP is recognized as the danger signals in the immune system through the Toll-like receptor 2, so both innate and adaptive immune responses can be induced by RLP; serves as an efficient and cost-effective bioprocess for producing RLP in Escherichia coli and the feasibility and safety of this core platform technology has been successfully demonstrated in animal model studies including meningococcal group B subunit vaccine, dengue subunit vaccine, novel subunit vaccine against Clostridium difficile-associated diseases and HPV-based immunotherapeutic vaccines." @default.
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- W2100078415 date "2015-09-30" @default.
- W2100078415 modified "2023-10-17" @default.
- W2100078415 title "Recombinant bacterial lipoproteins as vaccine candidates" @default.
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- W2100078415 doi "https://doi.org/10.1586/14760584.2015.1091732" @default.
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