FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100078599> ?p ?o ?g. }

• W2100078599 endingPage "539" @default.
• W2100078599 startingPage "531" @default.
• W2100078599 abstract "Introduction. Liver metastases (LM) are crucial prognostic manifestation of gastrointestinal stromal tumors (GIST). With the advent of tyrosine kinase inhibitors (TKI), management of metastatic GIST has radically changed. Long clinical follow-up provides an increased proportion of GIST patients with LM who are candidates for potentially curative therapy. Material and methods. Patients who underwent treatment for liver metastases of GIST between 2000-2009 in our department were included in the study. Mean follow-up was 84 months (range 40-145) months. In retrospective analysis we investigated clinical, macro-/microscopic and immunohistochemical criteria, surgical, interventional and TKI therapy as well. Results. In 87 GIST-patients we identified 25 (29%) patients with metastatic disease. Of these, 12 patients (14%) suffered from LM with a mean age of 60.5 (range, 35-75) years. Primary GIST were located at stomach (n = 4, 33%) or small intestine (n = 8, 67%); all of them expressed CD117 and/or CD34. LM were multiple (83%), distributed in both lobes (67%). They were detected synchronously with primary tumor in 33% and metachronously in 77%. All patients with liver involvement were considered to treatment with TKI. LM were resected (R0) in 4 patients (33%). In recurrent (2/4) and TKI resistant cases, interventional treatment (radiofrequency ablation) and TKI escalation were carried out. During a median follow-up of 84 months (range 30-152), 2 patients died (16.5%) for progressive disease and one patient for other reasons. Nine patients (75%) were alive. Conclusion. Treatment of LM from GIST needs a multimodal approach. TKI-therapy is required at any case. In case of respectability, surgery must be carried out. In unresectable cases or recurrent/progressive disease, interventional treatment or TKI escalation should be considered. Therefore, these patients need to be treated in experienced centres, where multimodal approaches are established." @default.
• W2100078599 created "2016-06-24" @default.
• W2100078599 creator A5024236651 @default.
• W2100078599 creator A5028499415 @default.
• W2100078599 creator A5045920845 @default.
• W2100078599 creator A5072546068 @default.
• W2100078599 date "2015-07-01" @default.
• W2100078599 modified "2023-09-23" @default.
• W2100078599 title "Management of liver metastases of gastrointestinal stromal tumors (GIST)" @default.
• W2100078599 cites W1518436277 @default.
• W2100078599 cites W1571206842 @default.
• W2100078599 cites W1933891757 @default.
• W2100078599 cites W1964559639 @default.
• W2100078599 cites W1964871513 @default.
• W2100078599 cites W1972340575 @default.
• W2100078599 cites W1974264673 @default.
• W2100078599 cites W1989717453 @default.
• W2100078599 cites W1995930366 @default.
• W2100078599 cites W2007793367 @default.
• W2100078599 cites W2008920989 @default.
• W2100078599 cites W2010410127 @default.
• W2100078599 cites W2012072945 @default.
• W2100078599 cites W2015015957 @default.
• W2100078599 cites W2018203820 @default.
• W2100078599 cites W2018433986 @default.
• W2100078599 cites W2024702786 @default.
• W2100078599 cites W2025933929 @default.
• W2100078599 cites W2028651533 @default.
• W2100078599 cites W2029006783 @default.
• W2100078599 cites W2054505642 @default.
• W2100078599 cites W2062428732 @default.
• W2100078599 cites W2063299240 @default.
• W2100078599 cites W2068926954 @default.
• W2100078599 cites W2076969962 @default.
• W2100078599 cites W2081259401 @default.
• W2100078599 cites W2084470612 @default.
• W2100078599 cites W2088413109 @default.
• W2100078599 cites W2091269418 @default.
• W2100078599 cites W2096998881 @default.
• W2100078599 cites W2106362355 @default.
• W2100078599 cites W2107464631 @default.
• W2100078599 cites W2120109991 @default.
• W2100078599 cites W2125434194 @default.
• W2100078599 cites W2137201108 @default.
• W2100078599 cites W2139511378 @default.
• W2100078599 cites W2143717276 @default.
• W2100078599 cites W2150501295 @default.
• W2100078599 cites W2150766319 @default.
• W2100078599 cites W2153104828 @default.
• W2100078599 cites W2155263737 @default.
• W2100078599 cites W2156143871 @default.
• W2100078599 cites W2156952758 @default.
• W2100078599 cites W2159360580 @default.
• W2100078599 cites W2165755320 @default.
• W2100078599 cites W2269193243 @default.
• W2100078599 cites W2314511842 @default.
• W2100078599 cites W88960155 @default.
• W2100078599 doi "https://doi.org/10.1016/s1665-2681(19)31175-5" @default.
• W2100078599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26019040" @default.
• W2100078599 hasPublicationYear "2015" @default.
• W2100078599 type Work @default.
• W2100078599 sameAs 2100078599 @default.
• W2100078599 citedByCount "28" @default.
• W2100078599 countsByYear W21000785992016 @default.
• W2100078599 countsByYear W21000785992017 @default.
• W2100078599 countsByYear W21000785992018 @default.
• W2100078599 countsByYear W21000785992019 @default.
• W2100078599 countsByYear W21000785992020 @default.
• W2100078599 countsByYear W21000785992021 @default.
• W2100078599 countsByYear W21000785992022 @default.
• W2100078599 countsByYear W21000785992023 @default.
• W2100078599 crossrefType "journal-article" @default.
• W2100078599 hasAuthorship W2100078599A5024236651 @default.
• W2100078599 hasAuthorship W2100078599A5028499415 @default.
• W2100078599 hasAuthorship W2100078599A5045920845 @default.
• W2100078599 hasAuthorship W2100078599A5072546068 @default.
• W2100078599 hasBestOaLocation W21000785991 @default.
• W2100078599 hasConcept C10205521 @default.
• W2100078599 hasConcept C126322002 @default.
• W2100078599 hasConcept C141071460 @default.
• W2100078599 hasConcept C143998085 @default.
• W2100078599 hasConcept C167135981 @default.
• W2100078599 hasConcept C16930146 @default.
• W2100078599 hasConcept C2775922572 @default.
• W2100078599 hasConcept C2776839831 @default.
• W2100078599 hasConcept C2777007597 @default.
• W2100078599 hasConcept C2777377203 @default.
• W2100078599 hasConcept C2778902805 @default.
• W2100078599 hasConcept C2779422922 @default.
• W2100078599 hasConcept C28328180 @default.
• W2100078599 hasConcept C54355233 @default.
• W2100078599 hasConcept C71924100 @default.
• W2100078599 hasConcept C86803240 @default.
• W2100078599 hasConcept C90924648 @default.
• W2100078599 hasConceptScore W2100078599C10205521 @default.
• W2100078599 hasConceptScore W2100078599C126322002 @default.
• W2100078599 hasConceptScore W2100078599C141071460 @default.
• W2100078599 hasConceptScore W2100078599C143998085 @default.

• next