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• W2100080763 abstract "BackgroundBone metastatic patients with osteosarcoma have a very poor prognosis. Targeted radiation therapy has been pursued as a valid alternative. The primary end point of this study was progression-free survival (PFS) at 4 months.Patients and methodsTwenty-two osteosarcoma patients were treated with Samarium-153 ethylenediaminetetramethylene phosphonic acid (153Sm-EDTMP) at various dosages. Administered activities ranged from 150 (3 mCi/kg) to 1140 MBq/kg (30 mCi/kg). Autologous hematopoietic stem cell infusion was carried out on day 14 after the 153Sm-EDTMP infusion.ResultsThe median PFS was 61 days (18–436 days) and the median overall survival (OS) was 189 days (31–1175 days). PFS and OS for the entire patient population were 32% [95% confidence interval (CI) 16–50] and 76% (95% CI 52–89) at 4 months, respectively. No statistical differences emerged according to 153Sm-EDTMP administered or 24-h retained activity. One-month pain palliation was only observed in a minority of subjects and in none at 4 months.ConclusionsBased on our series, the PFS is dramatically short even when higher activity of 153Sm-EDTMP is administered. This would mean that, even at high level, 153Sm-EDTMP is itself ineffective against relapsed osteosarcoma or the residual activity is too low to be active on these particular subsets of patients." @default.
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• W2100080763 date "2012-07-01" @default.
• W2100080763 modified "2023-09-23" @default.
• W2100080763 title "153Samarium-EDTMP administration followed by hematopoietic stem cell support for bone metastases in osteosarcoma patients" @default.
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• W2100080763 doi "https://doi.org/10.1093/annonc/mdr542" @default.
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