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- W2100080881 abstract "From the structure activity relationship, two new analogs, 2 and 3, of the potent progesterone antagonist mifepristone 1 have been designed. The syntheses of these two analogs have been achieved in eleven steps through modified synthetic sequences and improved procedures starting from (+)-estrone. In comparison with mifepristone 1, the relative binding affinities of compound 2 for the progesterone receptor was found to be more, whereas that of compound 3 was less." @default.
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- W2100080881 date "2000-03-01" @default.
- W2100080881 modified "2023-10-18" @default.
- W2100080881 title "Synthesis of 11β-(4-dimethylaminophenyl)-17β-hydroxy-17α- (3-methyl-1-butynyl)-4, 9-estradien-3-one and 11β-(4-acetophenyl)- 17β-hydroxy-17α-(3-methyl-1-butynyl)-4, 9-estradien-3-one: two new analogs of mifepristone (RU-486)☆,☆☆21☆☆ This work originated at the National Chemical Laboratory, Pune 411 008, India.,☆☆☆22☆☆☆ Dedicated to Prof. D. Nasipuri on his 75th birthday." @default.
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- W2100080881 doi "https://doi.org/10.1016/s0039-128x(99)00097-5" @default.
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