FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100081206> ?p ?o ?g. }

• W2100081206 endingPage "e31721" @default.
• W2100081206 startingPage "e31721" @default.
• W2100081206 abstract "Highly pathogenic avian influenza viruses (HPAIVs) cause severe disease in humans. There are no effective vaccines or antiviral therapies currently available to control fatal outbreaks due in part to the lack of understanding of virus-mediated immunopathology. In our study, we used hemagglutinin (HA) of H5N1 virus to investigate the related signaling pathways and their relationship to dysregulated innate immune reaction. We found the HA of H5N1 avian influenza triggered an abnormal innate immune signalling in the pulmonary epithelial cells, through an unusual process involving activation of Janus kinase 3 (JAK3) that is exclusively associated with γc chain and is essential for signaling via all γc cytokine receptors. By using a selective JAK3 inhibitor and JAK3 knockout mice, we have, for the first time, demonstrated the ability to target active JAK3 to counteract injury to the lungs and protect immunocytes from acute hypercytokinemia -induced destruction following the challenge of H5N1 HA in vitro and in vivo. On the basis of the present data, it appears that the efficacy of selective JAK3 inhibition is likely based on its ability to block multiple cytokines and protect against a superinflammatory response to pathogen-associated molecular patterns (PAMPs) attack. Our findings highlight the potential value of selective JAK3 inhibitor in treating the fatal immunopathology caused by H5N1 challenge." @default.
• W2100081206 created "2016-06-24" @default.
• W2100081206 creator A5007208327 @default.
• W2100081206 creator A5024300922 @default.
• W2100081206 creator A5065874877 @default.
• W2100081206 creator A5068816156 @default.
• W2100081206 date "2012-02-16" @default.
• W2100081206 modified "2023-10-16" @default.
• W2100081206 title "Hemagglutinin from the H5N1 Virus Activates Janus Kinase 3 to Dysregulate Innate Immunity" @default.
• W2100081206 cites W1518609319 @default.
• W2100081206 cites W1521515468 @default.
• W2100081206 cites W1523679951 @default.
• W2100081206 cites W1923814307 @default.
• W2100081206 cites W1971992050 @default.
• W2100081206 cites W1973108001 @default.
• W2100081206 cites W1975275391 @default.
• W2100081206 cites W1977142289 @default.
• W2100081206 cites W1978658172 @default.
• W2100081206 cites W1982379558 @default.
• W2100081206 cites W1988436330 @default.
• W2100081206 cites W1996311210 @default.
• W2100081206 cites W2011843272 @default.
• W2100081206 cites W2016084887 @default.
• W2100081206 cites W2030922722 @default.
• W2100081206 cites W2037006398 @default.
• W2100081206 cites W2038834254 @default.
• W2100081206 cites W2039027344 @default.
• W2100081206 cites W2042559377 @default.
• W2100081206 cites W2043232914 @default.
• W2100081206 cites W2046378278 @default.
• W2100081206 cites W2063409320 @default.
• W2100081206 cites W2064718903 @default.
• W2100081206 cites W2065812373 @default.
• W2100081206 cites W2085483983 @default.
• W2100081206 cites W2096755430 @default.
• W2100081206 cites W2101490573 @default.
• W2100081206 cites W2113038532 @default.
• W2100081206 cites W2117926449 @default.
• W2100081206 cites W2120113718 @default.
• W2100081206 cites W2121154174 @default.
• W2100081206 cites W2122399224 @default.
• W2100081206 cites W2122988122 @default.
• W2100081206 cites W2139372108 @default.
• W2100081206 cites W2145825913 @default.
• W2100081206 cites W2148183046 @default.
• W2100081206 cites W2150066073 @default.
• W2100081206 cites W2150086428 @default.
• W2100081206 cites W2154156088 @default.
• W2100081206 cites W2161983082 @default.
• W2100081206 cites W2166967671 @default.
• W2100081206 cites W2167017590 @default.
• W2100081206 cites W2167944937 @default.
• W2100081206 cites W2174493400 @default.
• W2100081206 cites W2290936009 @default.
• W2100081206 cites W2320873518 @default.
• W2100081206 cites W2402812416 @default.
• W2100081206 cites W4230115907 @default.
• W2100081206 doi "https://doi.org/10.1371/journal.pone.0031721" @default.
• W2100081206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3280993" @default.
• W2100081206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22359619" @default.
• W2100081206 hasPublicationYear "2012" @default.
• W2100081206 type Work @default.
• W2100081206 sameAs 2100081206 @default.
• W2100081206 citedByCount "16" @default.
• W2100081206 countsByYear W21000812062012 @default.
• W2100081206 countsByYear W21000812062013 @default.
• W2100081206 countsByYear W21000812062014 @default.
• W2100081206 countsByYear W21000812062015 @default.
• W2100081206 countsByYear W21000812062016 @default.
• W2100081206 countsByYear W21000812062017 @default.
• W2100081206 countsByYear W21000812062018 @default.
• W2100081206 countsByYear W21000812062019 @default.
• W2100081206 countsByYear W21000812062020 @default.
• W2100081206 countsByYear W21000812062021 @default.
• W2100081206 countsByYear W21000812062023 @default.
• W2100081206 crossrefType "journal-article" @default.
• W2100081206 hasAuthorship W2100081206A5007208327 @default.
• W2100081206 hasAuthorship W2100081206A5024300922 @default.
• W2100081206 hasAuthorship W2100081206A5065874877 @default.
• W2100081206 hasAuthorship W2100081206A5068816156 @default.
• W2100081206 hasBestOaLocation W21000812061 @default.
• W2100081206 hasConcept C129374314 @default.
• W2100081206 hasConcept C136449434 @default.
• W2100081206 hasConcept C159047783 @default.
• W2100081206 hasConcept C167672396 @default.
• W2100081206 hasConcept C183315844 @default.
• W2100081206 hasConcept C203014093 @default.
• W2100081206 hasConcept C2522874641 @default.
• W2100081206 hasConcept C2777546802 @default.
• W2100081206 hasConcept C2778690821 @default.
• W2100081206 hasConcept C2778692840 @default.
• W2100081206 hasConcept C519248777 @default.
• W2100081206 hasConcept C86803240 @default.
• W2100081206 hasConcept C8891405 @default.
• W2100081206 hasConceptScore W2100081206C129374314 @default.
• W2100081206 hasConceptScore W2100081206C136449434 @default.
• W2100081206 hasConceptScore W2100081206C159047783 @default.
• W2100081206 hasConceptScore W2100081206C167672396 @default.

• next