FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100082441> ?p ?o ?g. }

• W2100082441 endingPage "3832" @default.
• W2100082441 startingPage "3821" @default.
• W2100082441 abstract "Prognostic tests for patients with early-stage lung cancer may provide needed guidance on postoperative surveillance and therapeutic decisions. We used a novel strategy to develop and validate a prognostic classifier for early-stage lung cancer. Specifically, we focused on 42 genes with roles in lung cancer or cancer prognosis. Expression of these biologically relevant genes and their association with relapse-free survival (RFS) were evaluated using microarray data from 148 patients with stage I lung adenocarcinoma. Seven genes associated with RFS were further examined by quantitative reverse transcription PCR in 291 lung adenocarcinoma tissues from Japan, the United States, and Norway. Only BRCA1, HIF1A, DLC1, and XPO1 were each significantly associated with prognosis in the Japan and US/Norway cohorts. A Cox regression-based classifier was developed using these four genes on the Japan cohort and validated in stage I lung adenocarcinoma from the US/Norway cohort and three publicly available lung adenocarcinoma expression profiling datasets. The results suggest that the classifier is robust across ethnically and geographically diverse populations regardless of the technology used to measure gene expression. We evaluated the combination of the four-gene classifier with miRNA miR-21 (MIR21) expression and found that the combination improved associations with prognosis, which were significant in stratified analyses on stage IA and stage IB patients. Thus, the four coding gene classifier, alone or with miR-21 expression, may provide a clinically useful tool to identify high-risk patients and guide recommendations regarding adjuvant therapy and postoperative surveillance of patients with stage I lung adenocarcinoma." @default.
• W2100082441 created "2016-06-24" @default.
• W2100082441 creator A5016853321 @default.
• W2100082441 creator A5017457595 @default.
• W2100082441 creator A5025520229 @default.
• W2100082441 creator A5029703491 @default.
• W2100082441 creator A5031450216 @default.
• W2100082441 creator A5034572359 @default.
• W2100082441 creator A5035379638 @default.
• W2100082441 creator A5045259667 @default.
• W2100082441 creator A5046639249 @default.
• W2100082441 creator A5048943902 @default.
• W2100082441 creator A5048966043 @default.
• W2100082441 creator A5050126669 @default.
• W2100082441 creator A5053952871 @default.
• W2100082441 creator A5070619391 @default.
• W2100082441 creator A5071696225 @default.
• W2100082441 creator A5074805266 @default.
• W2100082441 creator A5081317288 @default.
• W2100082441 creator A5089787707 @default.
• W2100082441 creator A5091148741 @default.
• W2100082441 date "2013-06-30" @default.
• W2100082441 modified "2023-10-18" @default.
• W2100082441 title "Combination of Protein Coding and Noncoding Gene Expression as a Robust Prognostic Classifier in Stage I Lung Adenocarcinoma" @default.
• W2100082441 cites W1856360008 @default.
• W2100082441 cites W1966357431 @default.
• W2100082441 cites W1970476748 @default.
• W2100082441 cites W1989123634 @default.
• W2100082441 cites W1994025613 @default.
• W2100082441 cites W1997301858 @default.
• W2100082441 cites W2000771269 @default.
• W2100082441 cites W2009186258 @default.
• W2100082441 cites W2028453610 @default.
• W2100082441 cites W2029990894 @default.
• W2100082441 cites W2030048487 @default.
• W2100082441 cites W2037011799 @default.
• W2100082441 cites W2048410884 @default.
• W2100082441 cites W2064899027 @default.
• W2100082441 cites W2067915426 @default.
• W2100082441 cites W2075549113 @default.
• W2100082441 cites W2084001490 @default.
• W2100082441 cites W2085650758 @default.
• W2100082441 cites W2086333179 @default.
• W2100082441 cites W2091386615 @default.
• W2100082441 cites W2092332043 @default.
• W2100082441 cites W2092868756 @default.
• W2100082441 cites W2097413644 @default.
• W2100082441 cites W2103427526 @default.
• W2100082441 cites W2107986563 @default.
• W2100082441 cites W2108979762 @default.
• W2100082441 cites W2110225392 @default.
• W2100082441 cites W2117692326 @default.
• W2100082441 cites W2126415088 @default.
• W2100082441 cites W2127342594 @default.
• W2100082441 cites W2128753287 @default.
• W2100082441 cites W2131438131 @default.
• W2100082441 cites W2132165198 @default.
• W2100082441 cites W2135810600 @default.
• W2100082441 cites W2137761597 @default.
• W2100082441 cites W2140065103 @default.
• W2100082441 cites W2142351815 @default.
• W2100082441 cites W2142460765 @default.
• W2100082441 cites W2147925490 @default.
• W2100082441 cites W2147979281 @default.
• W2100082441 cites W2150688669 @default.
• W2100082441 cites W2155354546 @default.
• W2100082441 cites W2156001194 @default.
• W2100082441 cites W2158234609 @default.
• W2100082441 cites W2162038712 @default.
• W2100082441 cites W2164674592 @default.
• W2100082441 cites W2169354377 @default.
• W2100082441 cites W2169385429 @default.
• W2100082441 cites W4232719563 @default.
• W2100082441 doi "https://doi.org/10.1158/0008-5472.can-13-0031" @default.
• W2100082441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6503978" @default.
• W2100082441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23639940" @default.
• W2100082441 hasPublicationYear "2013" @default.
• W2100082441 type Work @default.
• W2100082441 sameAs 2100082441 @default.
• W2100082441 citedByCount "48" @default.
• W2100082441 countsByYear W21000824412013 @default.
• W2100082441 countsByYear W21000824412014 @default.
• W2100082441 countsByYear W21000824412015 @default.
• W2100082441 countsByYear W21000824412016 @default.
• W2100082441 countsByYear W21000824412017 @default.
• W2100082441 countsByYear W21000824412018 @default.
• W2100082441 countsByYear W21000824412019 @default.
• W2100082441 countsByYear W21000824412020 @default.
• W2100082441 countsByYear W21000824412021 @default.
• W2100082441 countsByYear W21000824412022 @default.
• W2100082441 countsByYear W21000824412023 @default.
• W2100082441 crossrefType "journal-article" @default.
• W2100082441 hasAuthorship W2100082441A5016853321 @default.
• W2100082441 hasAuthorship W2100082441A5017457595 @default.
• W2100082441 hasAuthorship W2100082441A5025520229 @default.
• W2100082441 hasAuthorship W2100082441A5029703491 @default.
• W2100082441 hasAuthorship W2100082441A5031450216 @default.
• W2100082441 hasAuthorship W2100082441A5034572359 @default.

• next