FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100083313> ?p ?o ?g. }

• W2100083313 endingPage "1455" @default.
• W2100083313 startingPage "1444" @default.
• W2100083313 abstract "Endometrial stromal cells (ESC) must undergo a hormone-driven differentiation to form decidual cells as a requirement of proper embryo implantation. Recent studies from our laboratory have demonstrated that decidualizing cells require glucose transporter 1 expression and an increase in glucose use to complete this step. The present study focuses on the glucose-dependent molecular and metabolic pathways, which are required by ESC for decidualization. Inhibition of glycolysis had no effect on decidualization. However, blockade of the pentose phosphate pathway (PPP) with pharmacologic inhibitors 6-aminonicotinamide or dehydroepiandrosterone (DHEA), and short hairpin RNA-mediated knockdown of glucose-6-phosphate dehydrogenase, the rate-limiting step in the PPP, both led to strong decreases in decidual marker expression in vitro and decreased decidualization in vivo. Additionally, the studies demonstrate that inhibition is due, at least in part, to ribose-5-phosphate depletion, because exogenous nucleoside administration restored decidualization in these cells. The finding that PPP inhibition prevents decidualization of ESC is novel and clinically important, because DHEA is an endogenous hormone produced by the adrenal glands and elevated in a high proportion of women who have polycystic ovary syndrome, the most common endocrinopathy in reproductive age women. Together, this data suggest a mechanistic link between increased DHEA levels, use of glucose via the PPP, and pregnancy loss." @default.
• W2100083313 created "2016-06-24" @default.
• W2100083313 creator A5000019972 @default.
• W2100083313 creator A5013787542 @default.
• W2100083313 creator A5084614665 @default.
• W2100083313 date "2011-08-01" @default.
• W2100083313 modified "2023-10-14" @default.
• W2100083313 title "Dehydroepiandrosterone Inhibits Glucose Flux Through the Pentose Phosphate Pathway in Human and Mouse Endometrial Stromal Cells, Preventing Decidualization and Implantation" @default.
• W2100083313 cites W1535461485 @default.
• W2100083313 cites W1601426514 @default.
• W2100083313 cites W1962519237 @default.
• W2100083313 cites W1966660410 @default.
• W2100083313 cites W1975014181 @default.
• W2100083313 cites W1986971982 @default.
• W2100083313 cites W1991266320 @default.
• W2100083313 cites W1995525548 @default.
• W2100083313 cites W2008733219 @default.
• W2100083313 cites W2018000046 @default.
• W2100083313 cites W2035779548 @default.
• W2100083313 cites W2039737646 @default.
• W2100083313 cites W2049014099 @default.
• W2100083313 cites W2052813166 @default.
• W2100083313 cites W2067483691 @default.
• W2100083313 cites W2069961599 @default.
• W2100083313 cites W2076477755 @default.
• W2100083313 cites W2076569607 @default.
• W2100083313 cites W2085446645 @default.
• W2100083313 cites W2085714106 @default.
• W2100083313 cites W2086071784 @default.
• W2100083313 cites W2093775195 @default.
• W2100083313 cites W2104171753 @default.
• W2100083313 cites W2118749429 @default.
• W2100083313 cites W2120403739 @default.
• W2100083313 cites W2121605257 @default.
• W2100083313 cites W2124121505 @default.
• W2100083313 cites W2155211270 @default.
• W2100083313 cites W2162158140 @default.
• W2100083313 cites W4211232189 @default.
• W2100083313 cites W4252553635 @default.
• W2100083313 cites W634127634 @default.
• W2100083313 doi "https://doi.org/10.1210/me.2011-0026" @default.
• W2100083313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3146244" @default.
• W2100083313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21680659" @default.
• W2100083313 hasPublicationYear "2011" @default.
• W2100083313 type Work @default.
• W2100083313 sameAs 2100083313 @default.
• W2100083313 citedByCount "64" @default.
• W2100083313 countsByYear W21000833132012 @default.
• W2100083313 countsByYear W21000833132013 @default.
• W2100083313 countsByYear W21000833132014 @default.
• W2100083313 countsByYear W21000833132015 @default.
• W2100083313 countsByYear W21000833132016 @default.
• W2100083313 countsByYear W21000833132017 @default.
• W2100083313 countsByYear W21000833132018 @default.
• W2100083313 countsByYear W21000833132019 @default.
• W2100083313 countsByYear W21000833132020 @default.
• W2100083313 countsByYear W21000833132021 @default.
• W2100083313 countsByYear W21000833132022 @default.
• W2100083313 countsByYear W21000833132023 @default.
• W2100083313 crossrefType "journal-article" @default.
• W2100083313 hasAuthorship W2100083313A5000019972 @default.
• W2100083313 hasAuthorship W2100083313A5013787542 @default.
• W2100083313 hasAuthorship W2100083313A5084614665 @default.
• W2100083313 hasBestOaLocation W21000833131 @default.
• W2100083313 hasConcept C126322002 @default.
• W2100083313 hasConcept C134018914 @default.
• W2100083313 hasConcept C16930146 @default.
• W2100083313 hasConcept C170493617 @default.
• W2100083313 hasConcept C2776992908 @default.
• W2100083313 hasConcept C2777911890 @default.
• W2100083313 hasConcept C2778316770 @default.
• W2100083313 hasConcept C2779742232 @default.
• W2100083313 hasConcept C502942594 @default.
• W2100083313 hasConcept C55493867 @default.
• W2100083313 hasConcept C71315377 @default.
• W2100083313 hasConcept C71924100 @default.
• W2100083313 hasConcept C7876069 @default.
• W2100083313 hasConcept C86803240 @default.
• W2100083313 hasConceptScore W2100083313C126322002 @default.
• W2100083313 hasConceptScore W2100083313C134018914 @default.
• W2100083313 hasConceptScore W2100083313C16930146 @default.
• W2100083313 hasConceptScore W2100083313C170493617 @default.
• W2100083313 hasConceptScore W2100083313C2776992908 @default.
• W2100083313 hasConceptScore W2100083313C2777911890 @default.
• W2100083313 hasConceptScore W2100083313C2778316770 @default.
• W2100083313 hasConceptScore W2100083313C2779742232 @default.
• W2100083313 hasConceptScore W2100083313C502942594 @default.
• W2100083313 hasConceptScore W2100083313C55493867 @default.
• W2100083313 hasConceptScore W2100083313C71315377 @default.
• W2100083313 hasConceptScore W2100083313C71924100 @default.
• W2100083313 hasConceptScore W2100083313C7876069 @default.
• W2100083313 hasConceptScore W2100083313C86803240 @default.
• W2100083313 hasIssue "8" @default.
• W2100083313 hasLocation W21000833131 @default.
• W2100083313 hasLocation W21000833132 @default.
• W2100083313 hasLocation W21000833133 @default.
• W2100083313 hasLocation W21000833134 @default.
• W2100083313 hasOpenAccess W2100083313 @default.

• next