FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100083951> ?p ?o ?g. }

• W2100083951 endingPage "1813" @default.
• W2100083951 startingPage "1803" @default.
• W2100083951 abstract "Obesity is a major public health problem with strong genetic determination; however, the genetic factors underlying obesity are largely unknown. In this study, we performed a genome-wide association scan for obesity by examining approximately 500 000 single-nucleotide polymorphisms (SNPs) in a sample of 1000 unrelated US Caucasians. We identified a novel gene, CTNNBL1, which has multiple SNPs associated with body mass index (BMI) and fat mass. The most significant SNP, rs6013029, achieved experiment-wise P-values of 2.69 × 10−7 for BMI and of 4.99 × 10−8 for fat mass, respectively. The SNP rs6013029 minor allele T confers an average increase in BMI and fat mass of 2.67 kg/m2 and 5.96 kg, respectively, compared with the alternative allele G. We further genotyped the five most significant CTNNBL1 SNPs in a French case–control sample comprising 896 class III obese adults (BMI ≥ 40 kg/m2) and 2916 lean adults (BMI < 25 kg/m2). All five SNPs showed consistent associations with obesity (8.83 × 10−3 < P < 6.96 × 10−4). Those subjects who were homozygous for the rs6013029 T allele had 1.42-fold increased odds of obesity compared with those without the T allele. The protein structure of CTNNBL1 is homologous to β-catenin, a family of proteins containing armadillo repeats, suggesting similar biological functions. β-Catenin is involved in the Wnt/β-catenin-signaling pathway which appears to contribute to maintaining the undifferentiated state of pre-adipocytes by inhibiting adipogenic gene expression. Our study hence suggests a novel mechanism for the development of obesity, where CTNNBL1 may play an important role. Our study also provided supportive evidence for previously identified associations between obesity and INSIG2 and PFKP, but not FTO." @default.
• W2100083951 created "2016-06-24" @default.
• W2100083951 creator A5007234866 @default.
• W2100083951 creator A5009611870 @default.
• W2100083951 creator A5012362939 @default.
• W2100083951 creator A5021537018 @default.
• W2100083951 creator A5024194480 @default.
• W2100083951 creator A5027380954 @default.
• W2100083951 creator A5034381224 @default.
• W2100083951 creator A5035511168 @default.
• W2100083951 creator A5045626839 @default.
• W2100083951 creator A5052478195 @default.
• W2100083951 creator A5074401104 @default.
• W2100083951 creator A5076081554 @default.
• W2100083951 creator A5078311783 @default.
• W2100083951 creator A5086664647 @default.
• W2100083951 creator A5088563078 @default.
• W2100083951 creator A5091298908 @default.
• W2100083951 date "2008-03-05" @default.
• W2100083951 modified "2023-10-18" @default.
• W2100083951 title "Genome-wide association scans identified CTNNBL1 as a novel gene for obesity" @default.
• W2100083951 cites W121766353 @default.
• W2100083951 cites W1546067400 @default.
• W2100083951 cites W1927710737 @default.
• W2100083951 cites W1964895626 @default.
• W2100083951 cites W1977848689 @default.
• W2100083951 cites W1981714996 @default.
• W2100083951 cites W1993507262 @default.
• W2100083951 cites W1995933703 @default.
• W2100083951 cites W1998641738 @default.
• W2100083951 cites W1998979801 @default.
• W2100083951 cites W2006762991 @default.
• W2100083951 cites W2009979246 @default.
• W2100083951 cites W2010867414 @default.
• W2100083951 cites W2011197968 @default.
• W2100083951 cites W2017126785 @default.
• W2100083951 cites W2025143098 @default.
• W2100083951 cites W2028335133 @default.
• W2100083951 cites W2043129312 @default.
• W2100083951 cites W2047031218 @default.
• W2100083951 cites W2048755332 @default.
• W2100083951 cites W2050099008 @default.
• W2100083951 cites W2056446739 @default.
• W2100083951 cites W2058401000 @default.
• W2100083951 cites W2063340056 @default.
• W2100083951 cites W2065218625 @default.
• W2100083951 cites W2066669827 @default.
• W2100083951 cites W2082122713 @default.
• W2100083951 cites W2092509345 @default.
• W2100083951 cites W2097660065 @default.
• W2100083951 cites W2101510083 @default.
• W2100083951 cites W2102945991 @default.
• W2100083951 cites W2106631668 @default.
• W2100083951 cites W2110678911 @default.
• W2100083951 cites W2110830484 @default.
• W2100083951 cites W2114243671 @default.
• W2100083951 cites W2116329478 @default.
• W2100083951 cites W2119279196 @default.
• W2100083951 cites W2120994472 @default.
• W2100083951 cites W2126718294 @default.
• W2100083951 cites W2134511980 @default.
• W2100083951 cites W2134783591 @default.
• W2100083951 cites W2144712959 @default.
• W2100083951 cites W2149385661 @default.
• W2100083951 cites W2149512324 @default.
• W2100083951 cites W2149791927 @default.
• W2100083951 cites W2152664025 @default.
• W2100083951 cites W2155449815 @default.
• W2100083951 cites W2157043398 @default.
• W2100083951 cites W2157752701 @default.
• W2100083951 cites W2162530578 @default.
• W2100083951 cites W2166254889 @default.
• W2100083951 cites W2988790836 @default.
• W2100083951 doi "https://doi.org/10.1093/hmg/ddn072" @default.
• W2100083951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2900891" @default.
• W2100083951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18325910" @default.
• W2100083951 hasPublicationYear "2008" @default.
• W2100083951 type Work @default.
• W2100083951 sameAs 2100083951 @default.
• W2100083951 citedByCount "172" @default.
• W2100083951 countsByYear W21000839512012 @default.
• W2100083951 countsByYear W21000839512013 @default.
• W2100083951 countsByYear W21000839512014 @default.
• W2100083951 countsByYear W21000839512015 @default.
• W2100083951 countsByYear W21000839512016 @default.
• W2100083951 countsByYear W21000839512017 @default.
• W2100083951 countsByYear W21000839512018 @default.
• W2100083951 countsByYear W21000839512019 @default.
• W2100083951 countsByYear W21000839512020 @default.
• W2100083951 countsByYear W21000839512021 @default.
• W2100083951 countsByYear W21000839512022 @default.
• W2100083951 countsByYear W21000839512023 @default.
• W2100083951 crossrefType "journal-article" @default.
• W2100083951 hasAuthorship W2100083951A5007234866 @default.
• W2100083951 hasAuthorship W2100083951A5009611870 @default.
• W2100083951 hasAuthorship W2100083951A5012362939 @default.
• W2100083951 hasAuthorship W2100083951A5021537018 @default.
• W2100083951 hasAuthorship W2100083951A5024194480 @default.

• next