FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100084105> ?p ?o ?g. }

• W2100084105 endingPage "1137" @default.
• W2100084105 startingPage "1130" @default.
• W2100084105 abstract "Abstract Resistance to chemotherapy is one of the principal causes of cancer mortality and is generally considered a late event in tumor progression. Although cellular models of drug resistance have been useful in identifying the molecules responsible for conferring drug resistance, most of these cellular models are derived from cell lines isolated from patients at a late stage in cancer progression. To ask at which stage in the tumorigenic progression does the cell gain the ability to acquire drug resistance, we generated a series of pretumorigenic and tumorigenic cells from human embryonic skin fibroblasts by introducing, sequentially, the catalytic subunit of telomerase, SV40 large T and small T oncoproteins, and an oncogenic form of ras. We show that the ability to acquire multidrug resistance (MDR) can arise before the malignant transformation stage. The minimal set of changes necessary to obtain pretumorigenic drug-resistant cells is expression of telomerase and inactivation of p53 and pRb. Thus, the pathways inactivated during tumorigenesis also confer the ability to acquire drug resistance. Microarray and functional studies of drug-resistant pretumorigenic cells indicate that the drug efflux pump P-glycoprotein is responsible for the MDR phenotype in this pretumorigenic cell model. [Cancer Res 2007;67(3):1130–7]" @default.
• W2100084105 created "2016-06-24" @default.
• W2100084105 creator A5006310817 @default.
• W2100084105 creator A5009056091 @default.
• W2100084105 creator A5023079178 @default.
• W2100084105 creator A5049601909 @default.
• W2100084105 creator A5055443428 @default.
• W2100084105 creator A5062520767 @default.
• W2100084105 creator A5065838425 @default.
• W2100084105 creator A5078072484 @default.
• W2100084105 creator A5084794925 @default.
• W2100084105 date "2007-02-01" @default.
• W2100084105 modified "2023-10-14" @default.
• W2100084105 title "Ability to Acquire Drug Resistance Arises Early during the Tumorigenesis Process" @default.
• W2100084105 cites W1545398558 @default.
• W2100084105 cites W1583419301 @default.
• W2100084105 cites W1611268078 @default.
• W2100084105 cites W1967331103 @default.
• W2100084105 cites W1983914017 @default.
• W2100084105 cites W1990481297 @default.
• W2100084105 cites W1992667313 @default.
• W2100084105 cites W1993606165 @default.
• W2100084105 cites W1994610109 @default.
• W2100084105 cites W1995596974 @default.
• W2100084105 cites W1997813173 @default.
• W2100084105 cites W2004550754 @default.
• W2100084105 cites W2006434892 @default.
• W2100084105 cites W2010397777 @default.
• W2100084105 cites W2013993442 @default.
• W2100084105 cites W2021807970 @default.
• W2100084105 cites W2030963645 @default.
• W2100084105 cites W2034269086 @default.
• W2100084105 cites W2038437697 @default.
• W2100084105 cites W2042125392 @default.
• W2100084105 cites W2044832154 @default.
• W2100084105 cites W2053673624 @default.
• W2100084105 cites W2055349083 @default.
• W2100084105 cites W2055904567 @default.
• W2100084105 cites W2057632732 @default.
• W2100084105 cites W2066429786 @default.
• W2100084105 cites W2078581194 @default.
• W2100084105 cites W2081120343 @default.
• W2100084105 cites W2083613146 @default.
• W2100084105 cites W2099764429 @default.
• W2100084105 cites W2117824620 @default.
• W2100084105 cites W2131308181 @default.
• W2100084105 cites W2138311952 @default.
• W2100084105 cites W2146199041 @default.
• W2100084105 cites W2148817007 @default.
• W2100084105 cites W2153172903 @default.
• W2100084105 cites W2169302611 @default.
• W2100084105 cites W2171507213 @default.
• W2100084105 doi "https://doi.org/10.1158/0008-5472.can-06-2574" @default.
• W2100084105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17283147" @default.
• W2100084105 hasPublicationYear "2007" @default.
• W2100084105 type Work @default.
• W2100084105 sameAs 2100084105 @default.
• W2100084105 citedByCount "50" @default.
• W2100084105 countsByYear W21000841052012 @default.
• W2100084105 countsByYear W21000841052013 @default.
• W2100084105 countsByYear W21000841052014 @default.
• W2100084105 countsByYear W21000841052015 @default.
• W2100084105 countsByYear W21000841052016 @default.
• W2100084105 countsByYear W21000841052017 @default.
• W2100084105 countsByYear W21000841052018 @default.
• W2100084105 countsByYear W21000841052019 @default.
• W2100084105 countsByYear W21000841052020 @default.
• W2100084105 countsByYear W21000841052021 @default.
• W2100084105 countsByYear W21000841052022 @default.
• W2100084105 countsByYear W21000841052023 @default.
• W2100084105 crossrefType "journal-article" @default.
• W2100084105 hasAuthorship W2100084105A5006310817 @default.
• W2100084105 hasAuthorship W2100084105A5009056091 @default.
• W2100084105 hasAuthorship W2100084105A5023079178 @default.
• W2100084105 hasAuthorship W2100084105A5049601909 @default.
• W2100084105 hasAuthorship W2100084105A5055443428 @default.
• W2100084105 hasAuthorship W2100084105A5062520767 @default.
• W2100084105 hasAuthorship W2100084105A5065838425 @default.
• W2100084105 hasAuthorship W2100084105A5078072484 @default.
• W2100084105 hasAuthorship W2100084105A5084794925 @default.
• W2100084105 hasConcept C104317684 @default.
• W2100084105 hasConcept C114851261 @default.
• W2100084105 hasConcept C121608353 @default.
• W2100084105 hasConcept C125593758 @default.
• W2100084105 hasConcept C133936738 @default.
• W2100084105 hasConcept C2779256057 @default.
• W2100084105 hasConcept C502942594 @default.
• W2100084105 hasConcept C54355233 @default.
• W2100084105 hasConcept C555283112 @default.
• W2100084105 hasConcept C86803240 @default.
• W2100084105 hasConcept C94581717 @default.
• W2100084105 hasConcept C96232424 @default.
• W2100084105 hasConceptScore W2100084105C104317684 @default.
• W2100084105 hasConceptScore W2100084105C114851261 @default.
• W2100084105 hasConceptScore W2100084105C121608353 @default.
• W2100084105 hasConceptScore W2100084105C125593758 @default.
• W2100084105 hasConceptScore W2100084105C133936738 @default.
• W2100084105 hasConceptScore W2100084105C2779256057 @default.

• next