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- W2100085438 abstract "Eighty specific-pathogen-free kittens 3 to 4 months old received a single s.c. injection of Snyder-Theilen feline sarcoma virus; this isolate contained helper feline leukemia virus (FeLV) at a sarcoma:leukemia ratio of 1:1.5. Recipients developed fibrosarcomas 13 to 15 days later at the virus injection site; then, for 10 days, the tumors grew rapidly in all animals and reached a mean diameter of 2.7 cm. Tumors subsequently regressed in 45% of the cats and disappeared by 40 days; regressor animals then remained tumor free. Tumors progressed in all other cats, and death occurred between 30 and 90 days of disseminated secondary deposits. Although circulating FeLV was detected in the blood from all cats before or at tumor appearance, Snyder-Theilen feline sarcoma virus was detected only in tumor progressors during the last 2 weeks of life. Peak FeLV burdens exceeded 1000 infectious particles and 2.0 µg of protein with a molecular weight of 30,000 per ml blood, but no correlation was found between tumor progress and leukemia virus load. One-half of the tumor regressor group also eliminated their virus infections. In these animals, virus-neutralizing antibody to both FeLV and Snyder-Theilen feline sarcoma virus was detected at high titer. In remaining regressor cats, the tumors disappeared, but viremia persisted, and no virus-neutralizing antibody activity to either virus was detected. Cytotoxic antibody to feline oncornavirus-associated cell membrane antigen was detected in high titer only in sera from the tumor regressor and the FeLV-negative group of cats, indicating that fibrosarcoma rejection and virus immunity are mediated by distinct mechanisms." @default.
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- W2100085438 date "1983-04-01" @default.
- W2100085438 modified "2023-09-23" @default.
- W2100085438 title "Circulating levels of feline leukemia and sarcoma viruses and fibrosarcoma regression in persistently viremic cats." @default.
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