FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100085626> ?p ?o ?g. }

• W2100085626 endingPage "153" @default.
• W2100085626 startingPage "148" @default.
• W2100085626 abstract "Whereas advances in the molecular biology of GABA(A) receptor complex using knock-out and knock-in mice have been valuable in unveiling the structure, composition, receptor assembly, and several functions of different GABA(A) receptor subtypes, the mechanism(s) underlying benzodiazepine (BZ) tolerance and withdrawal remain poorly understood. Studies using specific GABA(A) receptor subunit knock-in mice suggest that tolerance to sedative action of diazepam requires long-term activation of alpha1 and alpha5 GABA(A) receptor subunits. We investigated the role of long-term activation of these GABA(A) receptor subunits during anticonvulsant tolerance using high affinity and high intrinsic efficacy ligands for GABA(A) receptors expressing the alpha5 subunit (imidazenil) or alpha1 subunit (zolpidem), and a non-selective BZ recognition site ligand (diazepam). We report here that long-term activation of GABA(A) receptors by zolpidem and diazepam but not by imidazenil elicits anticonvulsant tolerance. Although anticonvulsant cross-tolerance occurs between diazepam and zolpidem, there is no cross-tolerance between imidazenil and diazepam or zolpidem. Furthermore, diazepam or zolpidem long-term treatment decreased the expression of mRNA encoding the alpha1 GABA(A) receptor subunit in prefrontal cortex by 43% and 20% respectively. In addition, diazepam but not zolpidem long-term treatment produced a 30% increase in the expression of the alpha5 GABA(A) receptor subunit mRNA in prefrontal cortex. In contrast, imidazenil which is devoid of anticonvulsant tolerance does not elicit significant changes in the expression of alpha1 or alpha5 GABA(A) receptor subunit. These findings suggest that long-term activation of GABA(A) receptors containing the alpha1 or other subunits but not the alpha5 receptor subunit is essential for the induction of anticonvulsant tolerance." @default.
• W2100085626 created "2016-06-24" @default.
• W2100085626 creator A5048825104 @default.
• W2100085626 creator A5051515082 @default.
• W2100085626 creator A5053936847 @default.
• W2100085626 creator A5077892371 @default.
• W2100085626 creator A5090826335 @default.
• W2100085626 date "2008-08-01" @default.
• W2100085626 modified "2023-09-26" @default.
• W2100085626 title "Imidazenil: A low efficacy agonist at α1- but high efficacy at α5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem" @default.
• W2100085626 cites W1554692577 @default.
• W2100085626 cites W1589111048 @default.
• W2100085626 cites W1605647047 @default.
• W2100085626 cites W1824285989 @default.
• W2100085626 cites W1879000632 @default.
• W2100085626 cites W1971336985 @default.
• W2100085626 cites W1974286622 @default.
• W2100085626 cites W1981592369 @default.
• W2100085626 cites W1983382176 @default.
• W2100085626 cites W1984047117 @default.
• W2100085626 cites W2001619275 @default.
• W2100085626 cites W2006638716 @default.
• W2100085626 cites W2008627941 @default.
• W2100085626 cites W2010368932 @default.
• W2100085626 cites W2011606970 @default.
• W2100085626 cites W2017165065 @default.
• W2100085626 cites W2036809519 @default.
• W2100085626 cites W2048238454 @default.
• W2100085626 cites W2058308027 @default.
• W2100085626 cites W2061366613 @default.
• W2100085626 cites W2072551779 @default.
• W2100085626 cites W2076076801 @default.
• W2100085626 cites W2077813306 @default.
• W2100085626 cites W2081822887 @default.
• W2100085626 cites W2082354081 @default.
• W2100085626 cites W2083623577 @default.
• W2100085626 cites W2090971121 @default.
• W2100085626 cites W2094151893 @default.
• W2100085626 cites W2095839932 @default.
• W2100085626 cites W2097643979 @default.
• W2100085626 cites W2108694451 @default.
• W2100085626 cites W2121237571 @default.
• W2100085626 cites W2134078774 @default.
• W2100085626 cites W2143086898 @default.
• W2100085626 cites W2162515150 @default.
• W2100085626 cites W2169205273 @default.
• W2100085626 cites W2169533599 @default.
• W2100085626 cites W2171381392 @default.
• W2100085626 doi "https://doi.org/10.1016/j.neuropharm.2008.05.002" @default.
• W2100085626 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2601598" @default.
• W2100085626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18555494" @default.
• W2100085626 hasPublicationYear "2008" @default.
• W2100085626 type Work @default.
• W2100085626 sameAs 2100085626 @default.
• W2100085626 citedByCount "31" @default.
• W2100085626 countsByYear W21000856262012 @default.
• W2100085626 countsByYear W21000856262014 @default.
• W2100085626 countsByYear W21000856262015 @default.
• W2100085626 countsByYear W21000856262016 @default.
• W2100085626 countsByYear W21000856262018 @default.
• W2100085626 countsByYear W21000856262020 @default.
• W2100085626 countsByYear W21000856262021 @default.
• W2100085626 crossrefType "journal-article" @default.
• W2100085626 hasAuthorship W2100085626A5048825104 @default.
• W2100085626 hasAuthorship W2100085626A5051515082 @default.
• W2100085626 hasAuthorship W2100085626A5053936847 @default.
• W2100085626 hasAuthorship W2100085626A5077892371 @default.
• W2100085626 hasAuthorship W2100085626A5090826335 @default.
• W2100085626 hasBestOaLocation W21000856262 @default.
• W2100085626 hasConcept C168258287 @default.
• W2100085626 hasConcept C169760540 @default.
• W2100085626 hasConcept C170493617 @default.
• W2100085626 hasConcept C185592680 @default.
• W2100085626 hasConcept C2775858608 @default.
• W2100085626 hasConcept C2776175493 @default.
• W2100085626 hasConcept C2777123777 @default.
• W2100085626 hasConcept C2778173252 @default.
• W2100085626 hasConcept C2778186239 @default.
• W2100085626 hasConcept C2778938600 @default.
• W2100085626 hasConcept C2781210498 @default.
• W2100085626 hasConcept C55493867 @default.
• W2100085626 hasConcept C86803240 @default.
• W2100085626 hasConcept C98274493 @default.
• W2100085626 hasConceptScore W2100085626C168258287 @default.
• W2100085626 hasConceptScore W2100085626C169760540 @default.
• W2100085626 hasConceptScore W2100085626C170493617 @default.
• W2100085626 hasConceptScore W2100085626C185592680 @default.
• W2100085626 hasConceptScore W2100085626C2775858608 @default.
• W2100085626 hasConceptScore W2100085626C2776175493 @default.
• W2100085626 hasConceptScore W2100085626C2777123777 @default.
• W2100085626 hasConceptScore W2100085626C2778173252 @default.
• W2100085626 hasConceptScore W2100085626C2778186239 @default.
• W2100085626 hasConceptScore W2100085626C2778938600 @default.
• W2100085626 hasConceptScore W2100085626C2781210498 @default.
• W2100085626 hasConceptScore W2100085626C55493867 @default.
• W2100085626 hasConceptScore W2100085626C86803240 @default.
• W2100085626 hasConceptScore W2100085626C98274493 @default.
• W2100085626 hasIssue "2" @default.

• next