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- W2100086856 abstract "Objective: The purpose of this analysis is to determine whether a significant correlation exists between cyclooxygenase-2 (COX-2) expression and local relapse in a large cohort of patients with T1 to 2N0 laryngeal cancer treated with primary radiation therapy. Methods and Materials: Clinical and molecular analyses were conducted on 123 patients with biopsy-proven T1 to 2N0 laryngeal cancer. Clinical prognostic factors included pretreatment hemoglobin, age, sex, race, T stage, tumor subsite, beam energy, biologically equivalent dose, therapy duration, and treatment date. Molecular prognostic factors included COX-2, p53, and Ki-67 expression. Expression levels were determined by immunohistochemistry on paraffin-embedded tissues arrayed on tissue microarrays. Multivariate analysis was done with the Cox proportional hazards model. Results: Thirty-two patients have locally relapsed, for an actuarial 5-year local relapse-free rate of 70.4%. On multivariate analysis, positive COX-2 expression predicted local relapse after radiation therapy. The relative risk (RR) for local relapse with COX-2 positivity was 2.57 (95% CI, 1.21–5.47; P = .01). Other prognostic factors for local relapse included negative Ki-67 expression (RR = 5.72; 95% CI, 2.04–16.1; P < .001), T2 stage (RR = 2.98; 95% CI, 1.39–6.38; P = .005), and therapy duration greater than 43 days (RR = 6.04; 95% CI, 1.37–26.7; P = .02). Conclusions: Positive COX-2 expression predicts for local relapse in T1 to 2N0 larynx cancer in a multivariate model. This relationship may have potential therapeutic implications regarding the use of COX-2 inhibitors during radiation therapy for optimal outcome." @default.
- W2100086856 created "2016-06-24" @default.
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- W2100086856 date "2004-11-01" @default.
- W2100086856 modified "2023-09-25" @default.
- W2100086856 title "Tissue Microarray Analysis Reveals Prognostic Significance of COX-2 Expression for Local Relapse in T1???2N0 Larynx Cancer Treated with Primary Radiation Therapy" @default.
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- W2100086856 doi "https://doi.org/10.1097/01.mlg.0000147936.67379.e7" @default.
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