Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100087067> ?p ?o ?g. }
- W2100087067 endingPage "543" @default.
- W2100087067 startingPage "537" @default.
- W2100087067 abstract "Sesquiterpene lactones containing an alpha-methylene-gamma-lactone moiety were shown to be potent inhibitors of carrageenan-induced edema and chronic adjuvant-induced arthritis in rodents at 2.5 mg/kg/day. The mode of action of sesquiterpene lactones as anti-inflammatory agents appeared to be at multiple sites; for example, at 5 X 10(-4) M, the sesquiterpene lactones effectively uncoupled the oxidative phosphorylation of human polymorphonuclear neutrophils and elevated the cyclic adenosine monophosphate levels of rat neutrophils and rat and mouse liver cells. Free and total lysosomal enzymatic activity was inhibited by these agents at 5 X 10(-4) M in both rat and mouse liver and rat and human neutrophils. Furthermore, the structure-activity relationships for the stabilization of lysosomal membrane for rat liver cathepsin activity followed the same structural requirement necessary for anti-inflammatory activity; i.e., the alpha-methylene-gamma-lactone moiety contributed the most activity, whereas the beta-unsubstituted cyclopentenone and alpha-epoxycyclopentanone contributed only minor activity. Human polymorphonuclear neutrophil chemotaxis was inhibited at low concentrations (i.e., 5 X 10(-5) and 5 X10(-6) M), whereas prostaglandin synthetase activity was inhibited at a higher concentration (i.e., 10(-3) M) by the sesquiterpene lactones." @default.
- W2100087067 created "2016-06-24" @default.
- W2100087067 creator A5000829756 @default.
- W2100087067 creator A5027971053 @default.
- W2100087067 creator A5055356086 @default.
- W2100087067 creator A5057351233 @default.
- W2100087067 date "1980-05-01" @default.
- W2100087067 modified "2023-10-17" @default.
- W2100087067 title "Mode of action of sesquiterpene lactones as anti-inflammatory agents" @default.
- W2100087067 cites W1484586543 @default.
- W2100087067 cites W1503540698 @default.
- W2100087067 cites W1819732475 @default.
- W2100087067 cites W1969736018 @default.
- W2100087067 cites W1981819970 @default.
- W2100087067 cites W1985342306 @default.
- W2100087067 cites W1986969351 @default.
- W2100087067 cites W1988606694 @default.
- W2100087067 cites W1995103348 @default.
- W2100087067 cites W2003254586 @default.
- W2100087067 cites W2007958557 @default.
- W2100087067 cites W2011500490 @default.
- W2100087067 cites W2038019042 @default.
- W2100087067 cites W2045489870 @default.
- W2100087067 cites W2047998256 @default.
- W2100087067 cites W2048078487 @default.
- W2100087067 cites W2052384349 @default.
- W2100087067 cites W2068180652 @default.
- W2100087067 cites W2075644215 @default.
- W2100087067 cites W2078578293 @default.
- W2100087067 cites W2079190725 @default.
- W2100087067 cites W2079359345 @default.
- W2100087067 cites W2081480195 @default.
- W2100087067 cites W2090334210 @default.
- W2100087067 cites W2090825908 @default.
- W2100087067 cites W2107412740 @default.
- W2100087067 cites W2107946939 @default.
- W2100087067 cites W2223155177 @default.
- W2100087067 cites W2415205045 @default.
- W2100087067 cites W2950550671 @default.
- W2100087067 cites W4313374357 @default.
- W2100087067 doi "https://doi.org/10.1002/jps.2600690516" @default.
- W2100087067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6247478" @default.
- W2100087067 hasPublicationYear "1980" @default.
- W2100087067 type Work @default.
- W2100087067 sameAs 2100087067 @default.
- W2100087067 citedByCount "116" @default.
- W2100087067 countsByYear W21000870672012 @default.
- W2100087067 countsByYear W21000870672013 @default.
- W2100087067 countsByYear W21000870672014 @default.
- W2100087067 countsByYear W21000870672015 @default.
- W2100087067 countsByYear W21000870672016 @default.
- W2100087067 countsByYear W21000870672017 @default.
- W2100087067 countsByYear W21000870672018 @default.
- W2100087067 countsByYear W21000870672020 @default.
- W2100087067 countsByYear W21000870672021 @default.
- W2100087067 countsByYear W21000870672023 @default.
- W2100087067 crossrefType "journal-article" @default.
- W2100087067 hasAuthorship W2100087067A5000829756 @default.
- W2100087067 hasAuthorship W2100087067A5027971053 @default.
- W2100087067 hasAuthorship W2100087067A5055356086 @default.
- W2100087067 hasAuthorship W2100087067A5057351233 @default.
- W2100087067 hasConcept C116073593 @default.
- W2100087067 hasConcept C121587506 @default.
- W2100087067 hasConcept C185592680 @default.
- W2100087067 hasConcept C202751555 @default.
- W2100087067 hasConcept C2776211264 @default.
- W2100087067 hasConcept C2776568683 @default.
- W2100087067 hasConcept C2776612806 @default.
- W2100087067 hasConcept C2777903533 @default.
- W2100087067 hasConcept C55493867 @default.
- W2100087067 hasConcept C71240020 @default.
- W2100087067 hasConceptScore W2100087067C116073593 @default.
- W2100087067 hasConceptScore W2100087067C121587506 @default.
- W2100087067 hasConceptScore W2100087067C185592680 @default.
- W2100087067 hasConceptScore W2100087067C202751555 @default.
- W2100087067 hasConceptScore W2100087067C2776211264 @default.
- W2100087067 hasConceptScore W2100087067C2776568683 @default.
- W2100087067 hasConceptScore W2100087067C2776612806 @default.
- W2100087067 hasConceptScore W2100087067C2777903533 @default.
- W2100087067 hasConceptScore W2100087067C55493867 @default.
- W2100087067 hasConceptScore W2100087067C71240020 @default.
- W2100087067 hasIssue "5" @default.
- W2100087067 hasLocation W21000870671 @default.
- W2100087067 hasLocation W21000870672 @default.
- W2100087067 hasOpenAccess W2100087067 @default.
- W2100087067 hasPrimaryLocation W21000870671 @default.
- W2100087067 hasRelatedWork W1487226417 @default.
- W2100087067 hasRelatedWork W1982987349 @default.
- W2100087067 hasRelatedWork W2027294102 @default.
- W2100087067 hasRelatedWork W2049373169 @default.
- W2100087067 hasRelatedWork W2058716433 @default.
- W2100087067 hasRelatedWork W2086400104 @default.
- W2100087067 hasRelatedWork W2091080095 @default.
- W2100087067 hasRelatedWork W2593859975 @default.
- W2100087067 hasRelatedWork W2751909492 @default.
- W2100087067 hasRelatedWork W2914793409 @default.
- W2100087067 hasVolume "69" @default.
- W2100087067 isParatext "false" @default.