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- W2100087285 abstract "Neurodegenerative disorders (NDs) are a complex group of illnesses that possibly share common mechanisms. The onset and progression of NDs may depend upon genetic traits as well as complex interactions between individual genetic backgrounds and environmental factors. The exact role of the risk factors involved, and how they influence the onset and pacing of the disease, is not yet fully understood. Similarly, the relationship between the rate of neuronal death and clinical expression of the disease is a matter for discussion. The knowledge of the various molecules and mechanisms that accompany NDs as primary or secondary events is increasing steadily, but the distinction between their physiological and pathological roles is still uncertain. These premises highlight the difficulties underlying the design of disease modifying strategies. However, it is possible to identify several disease modifying strategies based on various approaches, including the targeting of putative causal elements or of general mechanisms of degeneration and reparative strategies. The purpose of this review is to examine the biological rationale behind attempted protective, restorative and therapeutic strategies." @default.
- W2100087285 created "2016-06-24" @default.
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- W2100087285 date "2006-01-01" @default.
- W2100087285 modified "2023-09-25" @default.
- W2100087285 title "The search for disease-modifying drugs for neurodegenerative disorders" @default.
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- W2100087285 doi "https://doi.org/10.2217/14796708.1.1.87" @default.
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