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- W2100088556 abstract "Summary 1. Obesity and the accompanying metabolic syndrome are among the most important causes of cardiovascular pathologies associated with endothelial dysfunction, such as arterial hypertension and atherosclerosis. This detrimental effect of obesity is mediated, in part, by excessive production of the adipose tissue hormone leptin. 2. Under physiological conditions leptin induces endothelium‐dependent vasorelaxation by stimulating nitric oxide (NO) and endothelium‐derived hyperpolarizing factor (EDHF). Leptin activates endothelial NO synthase (eNOS) through a mechanism involving AMP‐activated protein kinase (AMPK) and protein kinase B/Akt, which phosphorylates eNOS at Ser 1177 , increasing its activity. 3. Under pathological conditions, such as obesity and metabolic syndrome, the NO‐mediated vasodilatory effect of leptin is impaired. Resistance to the acute NO‐mimetic effect of leptin is accounted for by chronic hyperleptinaemia and may result from different mechanisms, such as downregulation of leptin receptors, increased levels of circulating C‐reactive protein, oxidative stress and overexpression of suppressor of cytokine signalling‐3. 4. In short‐lasting obesity, impaired leptin‐induced NO production is compensated by EDHF; however, in advanced metabolic syndrome, the contribution of EDHF to the haemodynamic effect of leptin becomes inefficient. Resistance to the vasodilatory effects of leptin may contribute to the development of arterial hypertension owing to unopposed stimulation of the sympathetic nervous system by this hormone." @default.
- W2100088556 created "2016-06-24" @default.
- W2100088556 creator A5049277205 @default.
- W2100088556 date "2012-01-30" @default.
- W2100088556 modified "2023-10-02" @default.
- W2100088556 title "Leptin and the regulation of endothelial function in physiological and pathological conditions" @default.
- W2100088556 cites W1546660659 @default.
- W2100088556 cites W1574309809 @default.
- W2100088556 cites W1888630904 @default.
- W2100088556 cites W1964218374 @default.
- W2100088556 cites W1965753395 @default.
- W2100088556 cites W1970706622 @default.
- W2100088556 cites W1974838371 @default.
- W2100088556 cites W1976029372 @default.
- W2100088556 cites W1979190669 @default.
- W2100088556 cites W1980874227 @default.
- W2100088556 cites W1982580263 @default.
- W2100088556 cites W1991173655 @default.
- W2100088556 cites W1991552371 @default.
- W2100088556 cites W1992296149 @default.
- W2100088556 cites W1992869776 @default.
- W2100088556 cites W1996713062 @default.
- W2100088556 cites W1999874132 @default.
- W2100088556 cites W1999892971 @default.
- W2100088556 cites W2000469061 @default.
- W2100088556 cites W2006584817 @default.
- W2100088556 cites W2006919504 @default.
- W2100088556 cites W2011680378 @default.
- W2100088556 cites W2012264731 @default.
- W2100088556 cites W2012682110 @default.
- W2100088556 cites W2012737473 @default.
- W2100088556 cites W2016356617 @default.
- W2100088556 cites W2019407178 @default.
- W2100088556 cites W2020531103 @default.
- W2100088556 cites W2033638350 @default.
- W2100088556 cites W2035770221 @default.
- W2100088556 cites W2039749588 @default.
- W2100088556 cites W2040849501 @default.
- W2100088556 cites W2043290219 @default.
- W2100088556 cites W2046626174 @default.
- W2100088556 cites W2047373489 @default.
- W2100088556 cites W2048975480 @default.
- W2100088556 cites W2050225709 @default.
- W2100088556 cites W2050662404 @default.
- W2100088556 cites W2051738897 @default.
- W2100088556 cites W2052912538 @default.
- W2100088556 cites W2055315520 @default.
- W2100088556 cites W2057433633 @default.
- W2100088556 cites W2057624123 @default.
- W2100088556 cites W2060542548 @default.
- W2100088556 cites W2061340727 @default.
- W2100088556 cites W2062015016 @default.
- W2100088556 cites W2064489455 @default.
- W2100088556 cites W2069885706 @default.
- W2100088556 cites W2070743766 @default.
- W2100088556 cites W2072206476 @default.
- W2100088556 cites W2078827629 @default.
- W2100088556 cites W2084521532 @default.
- W2100088556 cites W2094041865 @default.
- W2100088556 cites W2097954820 @default.
- W2100088556 cites W2100811284 @default.
- W2100088556 cites W2103893515 @default.
- W2100088556 cites W2104302553 @default.
- W2100088556 cites W2104657159 @default.
- W2100088556 cites W2105987351 @default.
- W2100088556 cites W2113056258 @default.
- W2100088556 cites W2116376795 @default.
- W2100088556 cites W2117748926 @default.
- W2100088556 cites W2122796015 @default.
- W2100088556 cites W2129102792 @default.
- W2100088556 cites W2129275176 @default.
- W2100088556 cites W2137918867 @default.
- W2100088556 cites W2139895545 @default.
- W2100088556 cites W2142764567 @default.
- W2100088556 cites W2144799645 @default.
- W2100088556 cites W2145930882 @default.
- W2100088556 cites W2147464692 @default.
- W2100088556 cites W2149577090 @default.
- W2100088556 cites W2154964123 @default.
- W2100088556 cites W2162397977 @default.
- W2100088556 cites W2167345725 @default.
- W2100088556 cites W2170137975 @default.
- W2100088556 cites W2334159027 @default.
- W2100088556 doi "https://doi.org/10.1111/j.1440-1681.2011.05623.x" @default.
- W2100088556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21973116" @default.
- W2100088556 hasPublicationYear "2012" @default.
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