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• W2100090266 abstract "The interaction of the endogenous K-opioid, dynorphin, with N-methyl-D-aspartate (NMDA) receptors was studied in single periaqueductal gray (PAG) cells using the whole cell patch recording technique. We have found that dynorphin A (1-17) rapidly and reversibly potentiates NMDA-activated currents in a subpopulation of PAG cells. The potentiation cannot be blocked by the non-specific opioid antagonist, naloxone, nor can it be reversed by the specific kappa-opioid antagonist, nor-BNI. In addition, the non-opioid fragment of dynorphin, dynorphin A (2-17), is effective in potentiating NMDA currents, while the specific kappa-opioid, U50,488, cannot mimic the action of dynorphin A (1-17). The non-opioid dynorphin action and the rapid onset and recovery of the potentiation are consistent with the idea that dynorphin interacts directly with NMDA receptors in PAG cells." @default.
• W2100090266 created "2016-06-24" @default.
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• W2100090266 creator A5018355093 @default.
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• W2100090266 date "1998-05-01" @default.
• W2100090266 modified "2023-09-23" @default.
• W2100090266 title "Dynorphin uses a non-opioid mechanism to potentiate N-methyl-d-aspartate currents in single rat periaqueductal gray neurons" @default.
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• W2100090266 doi "https://doi.org/10.1016/s0304-3940(98)00293-6" @default.
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