Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100091582> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2100091582 endingPage "1486" @default.
- W2100091582 startingPage "1485" @default.
- W2100091582 abstract "Interferon induced HBeAg loss is persistent in up to 90% of patients with chronic hepatitis B (HBV).1–3 Older age and vertical transmission have been shown previously to be independent predictors of relapse after conventional IFN.4 Shorter duration of HBV DNA below 0.7 log10 IU/ml was found to predict relapse after lamivudine.5 Predictors of relapse after PEG-IFN treatment are, however, still unknown. Our aim in this study was to investigate the frequency and predictors of relapse after treatment with PEG-IFN α-2b alone or in combination with lamivudine.Data for this study were extracted from a multicentre randomised controlled trial comparing 52 weeks of PEG-IFN α-2b monotherapy (100 μg/week) with combined PEG-IFN and lamivudine (100 mg/day) in 266 patients with HBeAg positive chronic hepatitis B. The inclusion and exclusion criteria for the study were reported previously.6 Relapse was defined as HBeAg negativity at the end of treatment (week 52) and recurrence of HBeAg at the end of follow up (week 78).Treatment groups were comparable regarding baseline characteristics. At the end of treatment, 57 of 130 patients (44%) in the combination therapy group and 40 of 136 (29%) in the monotherapy group lost HBeAg (p = 0.01). HBeAg relapse occurred more often in patients treated with PEG-IFN α-2b and lamivudine combination therapy compared with PEG-IFN α-2b alone (22 of 57 patients (39%) vs five of 40 (13%), p = 0.005). Patients with HBeAg relapse were more likely to have relapse of HBV DNA >200 000 copies/ml than …" @default.
- W2100091582 created "2016-06-24" @default.
- W2100091582 creator A5031051209 @default.
- W2100091582 creator A5032528530 @default.
- W2100091582 creator A5034065954 @default.
- W2100091582 creator A5043626370 @default.
- W2100091582 creator A5067073858 @default.
- W2100091582 creator A5080844718 @default.
- W2100091582 creator A5085251225 @default.
- W2100091582 creator A5086698790 @default.
- W2100091582 creator A5089666483 @default.
- W2100091582 creator A5089933409 @default.
- W2100091582 date "2007-10-01" @default.
- W2100091582 modified "2023-09-27" @default.
- W2100091582 title "Relapse after treatment with peginterferon -2b alone or in combination with lamivudine in HBeAg positive chronic hepatitis B" @default.
- W2100091582 cites W1964039671 @default.
- W2100091582 cites W1968617408 @default.
- W2100091582 cites W1969872269 @default.
- W2100091582 cites W2008517556 @default.
- W2100091582 cites W2040989067 @default.
- W2100091582 cites W2101032357 @default.
- W2100091582 cites W2114688500 @default.
- W2100091582 cites W2130539964 @default.
- W2100091582 cites W2144263253 @default.
- W2100091582 doi "https://doi.org/10.1136/gut.2007.125633" @default.
- W2100091582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2000267" @default.
- W2100091582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17872587" @default.
- W2100091582 hasPublicationYear "2007" @default.
- W2100091582 type Work @default.
- W2100091582 sameAs 2100091582 @default.
- W2100091582 citedByCount "8" @default.
- W2100091582 countsByYear W21000915822013 @default.
- W2100091582 countsByYear W21000915822015 @default.
- W2100091582 crossrefType "journal-article" @default.
- W2100091582 hasAuthorship W2100091582A5031051209 @default.
- W2100091582 hasAuthorship W2100091582A5032528530 @default.
- W2100091582 hasAuthorship W2100091582A5034065954 @default.
- W2100091582 hasAuthorship W2100091582A5043626370 @default.
- W2100091582 hasAuthorship W2100091582A5067073858 @default.
- W2100091582 hasAuthorship W2100091582A5080844718 @default.
- W2100091582 hasAuthorship W2100091582A5085251225 @default.
- W2100091582 hasAuthorship W2100091582A5086698790 @default.
- W2100091582 hasAuthorship W2100091582A5089666483 @default.
- W2100091582 hasAuthorship W2100091582A5089933409 @default.
- W2100091582 hasBestOaLocation W21000915822 @default.
- W2100091582 hasConcept C126322002 @default.
- W2100091582 hasConcept C159047783 @default.
- W2100091582 hasConcept C2522874641 @default.
- W2100091582 hasConcept C2775940106 @default.
- W2100091582 hasConcept C2777382497 @default.
- W2100091582 hasConcept C2777410769 @default.
- W2100091582 hasConcept C2777869810 @default.
- W2100091582 hasConcept C2780593183 @default.
- W2100091582 hasConcept C3020491458 @default.
- W2100091582 hasConcept C71924100 @default.
- W2100091582 hasConcept C90924648 @default.
- W2100091582 hasConceptScore W2100091582C126322002 @default.
- W2100091582 hasConceptScore W2100091582C159047783 @default.
- W2100091582 hasConceptScore W2100091582C2522874641 @default.
- W2100091582 hasConceptScore W2100091582C2775940106 @default.
- W2100091582 hasConceptScore W2100091582C2777382497 @default.
- W2100091582 hasConceptScore W2100091582C2777410769 @default.
- W2100091582 hasConceptScore W2100091582C2777869810 @default.
- W2100091582 hasConceptScore W2100091582C2780593183 @default.
- W2100091582 hasConceptScore W2100091582C3020491458 @default.
- W2100091582 hasConceptScore W2100091582C71924100 @default.
- W2100091582 hasConceptScore W2100091582C90924648 @default.
- W2100091582 hasIssue "10" @default.
- W2100091582 hasLocation W21000915821 @default.
- W2100091582 hasLocation W21000915822 @default.
- W2100091582 hasLocation W21000915823 @default.
- W2100091582 hasLocation W21000915824 @default.
- W2100091582 hasOpenAccess W2100091582 @default.
- W2100091582 hasPrimaryLocation W21000915821 @default.
- W2100091582 hasRelatedWork W2088305891 @default.
- W2100091582 hasRelatedWork W2359618769 @default.
- W2100091582 hasRelatedWork W2378525013 @default.
- W2100091582 hasRelatedWork W2383627410 @default.
- W2100091582 hasRelatedWork W2386435459 @default.
- W2100091582 hasRelatedWork W2390606623 @default.
- W2100091582 hasRelatedWork W2392323650 @default.
- W2100091582 hasRelatedWork W2392939228 @default.
- W2100091582 hasRelatedWork W2405118428 @default.
- W2100091582 hasRelatedWork W3030031493 @default.
- W2100091582 hasVolume "56" @default.
- W2100091582 isParatext "false" @default.
- W2100091582 isRetracted "false" @default.
- W2100091582 magId "2100091582" @default.
- W2100091582 workType "article" @default.