FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100092640> ?p ?o ?g. }

• W2100092640 endingPage "2585" @default.
• W2100092640 startingPage "2575" @default.
• W2100092640 abstract "Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Cre reporter mouse system in conjunction with Cre-expressing HSV-1 recombinants we have previously shown that activation of the IE ICP0 promoter can precede latency establishment in at least 30 % of latently infected cells. During productive infection of non-neuronal cells, IE promoter activation is largely dependent on the transactivator VP16 a late structural component of the virion. Of significance, VP16 has recently been shown to exhibit altered regulation in neurones; where its de novo synthesis is necessary for IE gene expression during both lytic infection and reactivation from latency. In the current study, we utilized the Cre reporter mouse model system to characterize the full extent of viral promoter activity compatible with cell survival and latency establishment. In contrast to the high frequency activation of representative IE promoters prior to latency establishment, cell marking using a virus recombinant expressing Cre under VP16 promoter control was very inefficient. Furthermore, infection of neuronal cultures with VP16 mutants reveals a strong VP16 requirement for IE promoter activity in non-neuronal cells, but not sensory neurones. We conclude that only IE promoter activation can efficiently precede latency establishment and that this activation is likely to occur through a VP16-independent mechanism." @default.
• W2100092640 created "2016-06-24" @default.
• W2100092640 creator A5001463364 @default.
• W2100092640 creator A5031026129 @default.
• W2100092640 creator A5040394865 @default.
• W2100092640 creator A5058972704 @default.
• W2100092640 creator A5063488783 @default.
• W2100092640 creator A5071555511 @default.
• W2100092640 creator A5091463595 @default.
• W2100092640 date "2011-11-01" @default.
• W2100092640 modified "2023-10-16" @default.
• W2100092640 title "An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones" @default.
• W2100092640 cites W1578735362 @default.
• W2100092640 cites W1768274470 @default.
• W2100092640 cites W1847757368 @default.
• W2100092640 cites W1903481747 @default.
• W2100092640 cites W1938545417 @default.
• W2100092640 cites W1963816826 @default.
• W2100092640 cites W1966885880 @default.
• W2100092640 cites W1969468255 @default.
• W2100092640 cites W1982056995 @default.
• W2100092640 cites W1995049749 @default.
• W2100092640 cites W1995796039 @default.
• W2100092640 cites W1997816780 @default.
• W2100092640 cites W2000466396 @default.
• W2100092640 cites W2007735134 @default.
• W2100092640 cites W2013607556 @default.
• W2100092640 cites W2015438051 @default.
• W2100092640 cites W2025495144 @default.
• W2100092640 cites W2036173058 @default.
• W2100092640 cites W2038903818 @default.
• W2100092640 cites W2044442623 @default.
• W2100092640 cites W2054690927 @default.
• W2100092640 cites W2056170095 @default.
• W2100092640 cites W2056292706 @default.
• W2100092640 cites W2056295530 @default.
• W2100092640 cites W2058071990 @default.
• W2100092640 cites W2060300959 @default.
• W2100092640 cites W2072229797 @default.
• W2100092640 cites W2086573312 @default.
• W2100092640 cites W2093475210 @default.
• W2100092640 cites W2104280546 @default.
• W2100092640 cites W2106534896 @default.
• W2100092640 cites W2126134216 @default.
• W2100092640 cites W2127846162 @default.
• W2100092640 cites W2131792187 @default.
• W2100092640 cites W2134279163 @default.
• W2100092640 cites W2137698911 @default.
• W2100092640 cites W2142082591 @default.
• W2100092640 cites W2145548888 @default.
• W2100092640 cites W2148241125 @default.
• W2100092640 cites W2153854777 @default.
• W2100092640 cites W2161508569 @default.
• W2100092640 cites W2163424373 @default.
• W2100092640 cites W2165609174 @default.
• W2100092640 cites W2168808708 @default.
• W2100092640 cites W2169732257 @default.
• W2100092640 doi "https://doi.org/10.1099/vir.0.034728-0" @default.
• W2100092640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3541806" @default.
• W2100092640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21752961" @default.
• W2100092640 hasPublicationYear "2011" @default.
• W2100092640 type Work @default.
• W2100092640 sameAs 2100092640 @default.
• W2100092640 citedByCount "32" @default.
• W2100092640 countsByYear W21000926402012 @default.
• W2100092640 countsByYear W21000926402013 @default.
• W2100092640 countsByYear W21000926402014 @default.
• W2100092640 countsByYear W21000926402015 @default.
• W2100092640 countsByYear W21000926402016 @default.
• W2100092640 countsByYear W21000926402017 @default.
• W2100092640 countsByYear W21000926402018 @default.
• W2100092640 countsByYear W21000926402019 @default.
• W2100092640 countsByYear W21000926402020 @default.
• W2100092640 countsByYear W21000926402022 @default.
• W2100092640 countsByYear W21000926402023 @default.
• W2100092640 crossrefType "journal-article" @default.
• W2100092640 hasAuthorship W2100092640A5001463364 @default.
• W2100092640 hasAuthorship W2100092640A5031026129 @default.
• W2100092640 hasAuthorship W2100092640A5040394865 @default.
• W2100092640 hasAuthorship W2100092640A5058972704 @default.
• W2100092640 hasAuthorship W2100092640A5063488783 @default.
• W2100092640 hasAuthorship W2100092640A5071555511 @default.
• W2100092640 hasAuthorship W2100092640A5091463595 @default.
• W2100092640 hasBestOaLocation W21000926401 @default.
• W2100092640 hasConcept C101762097 @default.
• W2100092640 hasConcept C104317684 @default.
• W2100092640 hasConcept C119599485 @default.
• W2100092640 hasConcept C127413603 @default.
• W2100092640 hasConcept C1292079 @default.
• W2100092640 hasConcept C140704245 @default.
• W2100092640 hasConcept C143065580 @default.
• W2100092640 hasConcept C150194340 @default.
• W2100092640 hasConcept C159047783 @default.
• W2100092640 hasConcept C161733203 @default.
• W2100092640 hasConcept C182615771 @default.
• W2100092640 hasConcept C2522874641 @default.
• W2100092640 hasConcept C2778852064 @default.
• W2100092640 hasConcept C2779555244 @default.

• next