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- W2100093188 abstract "Intrachromosomal homologous recombination, manifest as reversion of a 14-kbp duplication in the hypoxanthine phosphoribosyl transferase (HPRT) gene, is elevated in human cells either stably transformed or transiently transfected by the SV40 (simian virus 40) large T antigen gene. Following introduction of wild-type SV40, or any of several T-antigen point mutations in a constant SV40 background, we observed a strong correlation between the stimulation of chromosomal recombination and induction of host-cell DNA synthesis. Moreover, inhibitors of DNA replication (aphidicolin and hydroxyurea) suppress SV40-induced homologous recombination to the extent that they suppress DNA synthesis. Stable integration of plasmids encoding T antigen also augments homologous recombination, which is suppressed by aphidicolin. We infer that the mechanism by which T antigen stimulates homologous recombination in human fibroblasts involves DNA replicative synthesis." @default.
- W2100093188 created "2016-06-24" @default.
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- W2100093188 date "1997-08-01" @default.
- W2100093188 modified "2023-10-03" @default.
- W2100093188 title "Induction of Duplication Reversion in Human Fibroblasts, by Wild-Type and Mutated SV40 T Antigen, Covaries With the Ability to Induce Host DNA Synthesis" @default.
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- W2100093188 doi "https://doi.org/10.1093/genetics/146.4.1417" @default.
- W2100093188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1208085" @default.
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