FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100093213> ?p ?o ?g. }

• W2100093213 endingPage "E439" @default.
• W2100093213 startingPage "E429" @default.
• W2100093213 abstract "A sucrose-rich diet (SRD), compared with a starch diet, induces time-dependent metabolic disorders and insulin resistance with hypertriglyceridemia, similar to type 2 diabetes. In this study, we examined the effect of SRD, after 8 mo, on nuclear receptors peroxisome proliferator-activated receptor-alpha (PPARalpha), and liver X receptor-alpha (LXRalpha), stearoyl-CoA desaturase-1 (SCD-1), and Delta6 and Delta5 desaturases mRNA and activity, hepatic enzymes involved in lipid metabolism, and fatty acid (FA) composition as well as the reversal produced by cod liver oil. SRD induced triglyceride increase in plasma and liver, increasing the anabolic FA synthase, malic enzyme, and glucose-6-phosphate dehydrogenase, but not the prooxidative enzymes FA oxidase and carnitine palmitoyltransferase I, and correspondingly decreased PPARalpha and increased LXRalpha expressions. Results suggest a contribution of both nuclear receptors' interaction on these enzymatic activities. SRD depressed SCD-1 without altering oleic acid proportion and increased Delta6 and Delta5 desaturases and the proportion of n-6 arachidonic acid. Therefore, the data do not support that SRD hypertriglyceridemia is produced by increased SCD-1-dependent oleic acid biosynthesis. The administration of 7% cod liver oil for 2 mo depressed LXRalpha, enhancing PPARalpha in control and SRD-fed rats, reversing the activity of the hepatic enzymes involved in lipid metabolism and therefore the hyperlipidemia produced by the SRD. Fish oil increased n-3 PUFA and depressed n-6 PUFA of liver lipids without altering the 18:1/18:0 ratio, suggesting that its effects were produced mainly by competition of dietary n-6 and n-3 FA and not through desaturase activity modification." @default.
• W2100093213 created "2016-06-24" @default.
• W2100093213 creator A5026348258 @default.
• W2100093213 creator A5035693201 @default.
• W2100093213 creator A5045225849 @default.
• W2100093213 creator A5045628575 @default.
• W2100093213 creator A5054658266 @default.
• W2100093213 creator A5060732730 @default.
• W2100093213 creator A5072038392 @default.
• W2100093213 creator A5080690361 @default.
• W2100093213 date "2010-03-01" @default.
• W2100093213 modified "2023-10-10" @default.
• W2100093213 title "Nuclear receptors and hepatic lipidogenic enzyme response to a dyslipidemic sucrose-rich diet and its reversal by fish oil n-3 polyunsaturated fatty acids" @default.
• W2100093213 cites W1521042725 @default.
• W2100093213 cites W1606867902 @default.
• W2100093213 cites W1644344232 @default.
• W2100093213 cites W1775749144 @default.
• W2100093213 cites W1841906170 @default.
• W2100093213 cites W1887418188 @default.
• W2100093213 cites W1895996242 @default.
• W2100093213 cites W1930740759 @default.
• W2100093213 cites W1938254948 @default.
• W2100093213 cites W1955389669 @default.
• W2100093213 cites W1967286688 @default.
• W2100093213 cites W1968659767 @default.
• W2100093213 cites W1973425173 @default.
• W2100093213 cites W1978727574 @default.
• W2100093213 cites W1979186609 @default.
• W2100093213 cites W1979383399 @default.
• W2100093213 cites W1991002926 @default.
• W2100093213 cites W1995641249 @default.
• W2100093213 cites W2006611752 @default.
• W2100093213 cites W2008654273 @default.
• W2100093213 cites W2016676112 @default.
• W2100093213 cites W2017454449 @default.
• W2100093213 cites W2017918116 @default.
• W2100093213 cites W2026454238 @default.
• W2100093213 cites W2029806465 @default.
• W2100093213 cites W2035697025 @default.
• W2100093213 cites W2038941282 @default.
• W2100093213 cites W2042511422 @default.
• W2100093213 cites W2047488857 @default.
• W2100093213 cites W2050609146 @default.
• W2100093213 cites W2051883615 @default.
• W2100093213 cites W2054631443 @default.
• W2100093213 cites W2061930293 @default.
• W2100093213 cites W2065485581 @default.
• W2100093213 cites W2067193582 @default.
• W2100093213 cites W2070237777 @default.
• W2100093213 cites W2073012362 @default.
• W2100093213 cites W2077737366 @default.
• W2100093213 cites W2080109922 @default.
• W2100093213 cites W2081536949 @default.
• W2100093213 cites W2091277139 @default.
• W2100093213 cites W2099363307 @default.
• W2100093213 cites W2100460378 @default.
• W2100093213 cites W2126420509 @default.
• W2100093213 cites W2127089274 @default.
• W2100093213 cites W2137001845 @default.
• W2100093213 cites W2138419705 @default.
• W2100093213 cites W2142100624 @default.
• W2100093213 cites W2143687302 @default.
• W2100093213 cites W2147627625 @default.
• W2100093213 cites W2148895935 @default.
• W2100093213 cites W2150977089 @default.
• W2100093213 cites W2154411879 @default.
• W2100093213 cites W2162558399 @default.
• W2100093213 cites W2167309923 @default.
• W2100093213 cites W2168526937 @default.
• W2100093213 cites W2169085802 @default.
• W2100093213 cites W2170050558 @default.
• W2100093213 cites W2171119762 @default.
• W2100093213 cites W4254630428 @default.
• W2100093213 doi "https://doi.org/10.1152/ajpendo.00513.2009" @default.
• W2100093213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19952344" @default.
• W2100093213 hasPublicationYear "2010" @default.
• W2100093213 type Work @default.
• W2100093213 sameAs 2100093213 @default.
• W2100093213 citedByCount "46" @default.
• W2100093213 countsByYear W21000932132012 @default.
• W2100093213 countsByYear W21000932132013 @default.
• W2100093213 countsByYear W21000932132014 @default.
• W2100093213 countsByYear W21000932132015 @default.
• W2100093213 countsByYear W21000932132016 @default.
• W2100093213 countsByYear W21000932132017 @default.
• W2100093213 countsByYear W21000932132018 @default.
• W2100093213 countsByYear W21000932132019 @default.
• W2100093213 countsByYear W21000932132020 @default.
• W2100093213 countsByYear W21000932132021 @default.
• W2100093213 countsByYear W21000932132022 @default.
• W2100093213 countsByYear W21000932132023 @default.
• W2100093213 crossrefType "journal-article" @default.
• W2100093213 hasAuthorship W2100093213A5026348258 @default.
• W2100093213 hasAuthorship W2100093213A5035693201 @default.
• W2100093213 hasAuthorship W2100093213A5045225849 @default.
• W2100093213 hasAuthorship W2100093213A5045628575 @default.
• W2100093213 hasAuthorship W2100093213A5054658266 @default.
• W2100093213 hasAuthorship W2100093213A5060732730 @default.

• next