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- W2100093402 abstract "<h3>Objective</h3>To report first experiences with interleukin 6 receptor inhibition in therapy-resistant neuromyelitis optica (NMO).<h3>Design</h3>Retrospective case series.<h3>Setting</h3>Neurology department at a tertiary referral center.<h3>Patients</h3>Patients with an aggressive course of NMO switched to tocilizumab after failure of anti-CD20 therapy.<h3>Main Outcome Measures</h3>Annualized relapse rate and disability progression measured by the Expanded Disability Status Scale.<h3>Results</h3>We report 3 female patients with a median age of 39 years (range, 26-40 years) and aquaporin 4–positive NMO. All patients had been treated with different immunosuppressive and immunomodulating agents, followed by 1 to 3 cycles of rituximab. Despite complete CD20-cell depletion during rituximab therapy, the median annualized relapse rate was 3.0 (range, 2.3-3.0) and the median Expanded Disability Status Scale score increased from 5.0 (range, 4.5-7.0) to 6.5 (range, 5.0-7.0). After the switch to tocilizumab (median duration of therapy, 18 months), the median annualized relapse rate decreased to 0.6 (range, 0-1.3). A total of 2 relapses occurred; however, they were mild and there were no changes in clinical disability.<h3>Conclusions</h3>Interleukin 6 receptor–blocking therapy can be effective in therapy-resistant cases of NMO. Larger controlled studies are needed to confirm the efficacy of tocilizumab." @default.
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- W2100093402 date "2013-03-01" @default.
- W2100093402 modified "2023-10-16" @default.
- W2100093402 title "Interleukin 6 Receptor Blockade in Patients With Neuromyelitis Optica Nonresponsive to Anti-CD20 Therapy" @default.
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- W2100093402 doi "https://doi.org/10.1001/jamaneurol.2013.1246" @default.
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