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- W2100093408 abstract "Parkinsonism hyperpyrexia syndrome (PHS) is a life-threatening condition seen in Parkinson disease (PD) characterized by high fever, muscle rigidity, elevated creatine phosphokinase (CPK), autonomic instability, and altered consciousness. Serious complications, such as rhabdomyolysis, renal failure, disseminated intravascular coagulation, and infections, are common.1,–,3 Withdrawal from dopamine replacement therapy (DRT), infection, injury, surgery, dehydration, and metabolic abnormalities can provoke PHS.4 Treatment includes increasing the frequency of DRT and management of systemic complications. Mortality is 4% if treated and 16% if untreated.5,6 Among survivors, 30% have worsening of symptoms of parkinsonism and never return to their baseline.A 52-year-old woman with a 17-year history of PD was referred for deep brain stimulation (DBS) surgery. She had bilateral tremor, rigidity, gait impairment, postural instability, motor fluctuations with dyskinesias, and wearing off symptoms of limb dystonia and freezing. Medications included carbidopa/levodopa (CD/LD) and amantadine. The Unified Parkinson's Disease Rating Scale–motor subscore (UPDRS-III) in a challenged “on” state was 27 (video 1 on the Neurology ® Web site at www.neurology.org). Off medication (>12 hours) she had such severe tremor and rigidity in the waiting area that a physician passing by …" @default.
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- W2100093408 date "2011-02-14" @default.
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- W2100093408 title "Deep Brain Stimulation in On-State Parkinson Hyperpyrexia" @default.
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- W2100093408 doi "https://doi.org/10.1212/wnl.0b013e31820c35c7" @default.
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