FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100093779> ?p ?o ?g. }

• W2100093779 endingPage "G972" @default.
• W2100093779 startingPage "G964" @default.
• W2100093779 abstract "Glucagon-like peptide-2 (GLP-2) is an intestinal trophic enteroendocrine peptide that is associated with intestinal adaptation following resection. Herein, we investigate the effects of GLP-2 in a total parenteral nutrition (TPN)-supported model of experimental short bowel syndrome. Juvenile Sprague-Dawley rats underwent a 90% small intestinal resection and jugular catheter insertion. Rats were randomized to three groups: enteral diet and intravenous saline infusion, TPN only, or TPN + 10 microg.kg(-1).h(-1) GLP-2. Nutritional maintenance was isocaloric and isonitrogenous. After 7 days, intestinal permeability was assessed by quantifying the urinary recovery of gavaged carbohydrate probes. The following day, animals were euthanized, and intestinal tissue was processed for morphological and crypt cell proliferation (CCP) analysis, apoptosis (caspase-3), and expression of SGLT-1 and GLUT-5 transport proteins. TPN plus GLP-2 treatment resulted in increased bowel and body weight, villus height, intestinal mucosal surface area, CCP, and reduced intestinal permeability compared with the TPN alone animals (P < 0.05). GLP-2 treatment induced increases in serum GLP-2 levels and intestinal SGLT-1 expression (P < 0.01) compared with either TPN or enteral groups. No differences were seen in the villus apoptotic index between resection groups. Enterally fed resected animals had a significant decrease in crypt apoptotic indexes compared with nontreated animals. This study demonstrates that GLP-2 alone, without enteral feeding, stimulates indexes of intestinal adaptation. Secondly, villus hypertrophy associated with adaptation was predominantly due to an increase in CCP and not to changes in apoptotic rates. Further studies are warranted to establish the mechanisms of action and therapeutic potential of GLP-2." @default.
• W2100093779 created "2016-06-24" @default.
• W2100093779 creator A5032640413 @default.
• W2100093779 creator A5056346068 @default.
• W2100093779 creator A5084326812 @default.
• W2100093779 date "2004-06-01" @default.
• W2100093779 modified "2023-10-10" @default.
• W2100093779 title "Glucagon-like peptide-2 induces intestinal adaptation in parenterally fed rats with short bowel syndrome" @default.
• W2100093779 cites W1501026265 @default.
• W2100093779 cites W1563711875 @default.
• W2100093779 cites W1752824908 @default.
• W2100093779 cites W1775749144 @default.
• W2100093779 cites W1890289904 @default.
• W2100093779 cites W1965215268 @default.
• W2100093779 cites W1972417331 @default.
• W2100093779 cites W1984463421 @default.
• W2100093779 cites W1985051436 @default.
• W2100093779 cites W1986722710 @default.
• W2100093779 cites W1987513354 @default.
• W2100093779 cites W1988650166 @default.
• W2100093779 cites W1995657749 @default.
• W2100093779 cites W1999979600 @default.
• W2100093779 cites W2002764863 @default.
• W2100093779 cites W2009356062 @default.
• W2100093779 cites W2010238950 @default.
• W2100093779 cites W2011879223 @default.
• W2100093779 cites W2013395086 @default.
• W2100093779 cites W2018569071 @default.
• W2100093779 cites W2020023892 @default.
• W2100093779 cites W2023441446 @default.
• W2100093779 cites W2024585422 @default.
• W2100093779 cites W2029391105 @default.
• W2100093779 cites W2054842789 @default.
• W2100093779 cites W2055371274 @default.
• W2100093779 cites W2060571271 @default.
• W2100093779 cites W2060762255 @default.
• W2100093779 cites W2065131269 @default.
• W2100093779 cites W2066992373 @default.
• W2100093779 cites W2079459104 @default.
• W2100093779 cites W2081576822 @default.
• W2100093779 cites W2089031162 @default.
• W2100093779 cites W2091189385 @default.
• W2100093779 cites W2094085879 @default.
• W2100093779 cites W2097613394 @default.
• W2100093779 cites W2102074325 @default.
• W2100093779 cites W2117862347 @default.
• W2100093779 cites W2119051785 @default.
• W2100093779 cites W2131132996 @default.
• W2100093779 cites W2138831474 @default.
• W2100093779 cites W2138867063 @default.
• W2100093779 cites W2138997261 @default.
• W2100093779 cites W2156474830 @default.
• W2100093779 cites W2160080698 @default.
• W2100093779 cites W2168284970 @default.
• W2100093779 cites W2170048668 @default.
• W2100093779 cites W2174791196 @default.
• W2100093779 cites W2232494808 @default.
• W2100093779 cites W2283637872 @default.
• W2100093779 cites W2346582744 @default.
• W2100093779 cites W2413398201 @default.
• W2100093779 cites W2574186914 @default.
• W2100093779 cites W2946970427 @default.
• W2100093779 cites W4233988411 @default.
• W2100093779 doi "https://doi.org/10.1152/ajpgi.00509.2003" @default.
• W2100093779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14962847" @default.
• W2100093779 hasPublicationYear "2004" @default.
• W2100093779 type Work @default.
• W2100093779 sameAs 2100093779 @default.
• W2100093779 citedByCount "128" @default.
• W2100093779 countsByYear W21000937792012 @default.
• W2100093779 countsByYear W21000937792013 @default.
• W2100093779 countsByYear W21000937792014 @default.
• W2100093779 countsByYear W21000937792015 @default.
• W2100093779 countsByYear W21000937792016 @default.
• W2100093779 countsByYear W21000937792017 @default.
• W2100093779 countsByYear W21000937792018 @default.
• W2100093779 countsByYear W21000937792019 @default.
• W2100093779 countsByYear W21000937792020 @default.
• W2100093779 countsByYear W21000937792021 @default.
• W2100093779 countsByYear W21000937792022 @default.
• W2100093779 countsByYear W21000937792023 @default.
• W2100093779 crossrefType "journal-article" @default.
• W2100093779 hasAuthorship W2100093779A5032640413 @default.
• W2100093779 hasAuthorship W2100093779A5056346068 @default.
• W2100093779 hasAuthorship W2100093779A5084326812 @default.
• W2100093779 hasConcept C126322002 @default.
• W2100093779 hasConcept C134018914 @default.
• W2100093779 hasConcept C190283241 @default.
• W2100093779 hasConcept C2777226302 @default.
• W2100093779 hasConcept C2777882243 @default.
• W2100093779 hasConcept C2779281246 @default.
• W2100093779 hasConcept C2779820108 @default.
• W2100093779 hasConcept C2781071285 @default.
• W2100093779 hasConcept C2781219945 @default.
• W2100093779 hasConcept C44315111 @default.
• W2100093779 hasConcept C55493867 @default.
• W2100093779 hasConcept C66090201 @default.
• W2100093779 hasConcept C71924100 @default.

• next