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- W2100093922 abstract "Abstract Inter‐ α ‐trypsin inhibitors are protease inhibitors that are thought to be important regulators in various acute‐phase processes. They are composed of one light chain (bikunin) and different heavy chains ( ITIH s). The only function known so far of ITIH s is the covalent linkage to hyaluronan ( HA ). As there is virtually no knowledge on the distribution and function of ITIH proteins in skin tissue, we performed a systematic characterization of ITIH expression in healthy and diseased skin. Using GeneChip ® Human Exon 1.0 ST expression profiling, we found that ITIH 5 represents the major ITIH family member expressed in human skin. Moreover, the use of quantitative reverse transcription PCR and a customized ITIH 5‐specific antibody indicated that ITIH 5 is predominantly produced by dermal fibroblasts. Immunohistochemical analysis revealed a clearly detectable ITIH 5 protein expression in normal skin. Interestingly, ITIH 5 expression was significantly up‐regulated in inflammatory skin diseases. Furthermore, 3D skin models employing murine Itih5 −/− epidermal keratinocytes and dermal fibroblasts as well as skin specimens of Itih5 −/− mice revealed a significantly altered epidermal structure compared to wild‐type controls. Hence, we can strengthen the presumption that ITIH 5 may constitute a novel regulatory molecule of the human skin that could play an important role in inflammation via its interaction with HA ." @default.
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- W2100093922 date "2015-04-17" @default.
- W2100093922 modified "2023-09-25" @default.
- W2100093922 title "Inter-<i>α</i>-trypsin inhibitor heavy chain 5 (ITIH5) is overexpressed in inflammatory skin diseases and affects epidermal morphology in constitutive knockout mice and murine 3D skin models" @default.
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- W2100093922 doi "https://doi.org/10.1111/exd.12704" @default.
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