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- W2100094474 abstract "Summary. Hepatitis C virus (HCV) causes significant morbidity and mortality worldwide with nearly 3% of the world population infected by this virus. Fortunately, this virus does not establish latency, and hence it may be possible to eradicate it. HCV is strongly associated with liver cirrhosis and hepatocellular carcinoma and is currently treated with pegylated interferon-α (peg-IFN-α) and ribavirin. Unfortunately, these limited treatment options often produce significant side effects, and currently, complete eradication of virus with combined drug modalities has not yet been achieved for the majority of chronically HCV-infected individuals. Restricted treatment options, lack of a universal cure for HCV and the link between chronic infection, liver cirrhosis and hepatocellular carcinoma necessitate design of novel drugs and treatment options. Understanding the relationship between the immune response, viral clearance and inhibition of viral replication with pharmacology-based design can ultimately allow for complete eradication of HCV. This review focuses upon significant novel preclinical and clinical specifically targeted antiviral therapy (STAT-C) drugs under development, highlights their mechanism of action, and discusses their impact on systemic viral loads and permanent clearance of infection." @default.
- W2100094474 created "2016-06-24" @default.
- W2100094474 creator A5013698403 @default.
- W2100094474 creator A5051240459 @default.
- W2100094474 creator A5087052821 @default.
- W2100094474 date "2010-02-01" @default.
- W2100094474 modified "2023-10-17" @default.
- W2100094474 title "HCV drug discovery aimed at viral eradication" @default.
- W2100094474 cites W100710130 @default.
- W2100094474 cites W1967244561 @default.
- W2100094474 cites W1969846303 @default.
- W2100094474 cites W1973127746 @default.
- W2100094474 cites W1974468227 @default.
- W2100094474 cites W1976569781 @default.
- W2100094474 cites W1985221317 @default.
- W2100094474 cites W1986166957 @default.
- W2100094474 cites W1986783319 @default.
- W2100094474 cites W1990396504 @default.
- W2100094474 cites W1992697586 @default.
- W2100094474 cites W1993245198 @default.
- W2100094474 cites W1993496957 @default.
- W2100094474 cites W1994522540 @default.
- W2100094474 cites W1998687750 @default.
- W2100094474 cites W2003579943 @default.
- W2100094474 cites W2003837723 @default.
- W2100094474 cites W2005017684 @default.
- W2100094474 cites W2006309458 @default.
- W2100094474 cites W2010150738 @default.
- W2100094474 cites W2010546204 @default.
- W2100094474 cites W2010791234 @default.
- W2100094474 cites W2011978083 @default.
- W2100094474 cites W2012929232 @default.
- W2100094474 cites W2013298304 @default.
- W2100094474 cites W2014024036 @default.
- W2100094474 cites W2017624799 @default.
- W2100094474 cites W2018339055 @default.
- W2100094474 cites W2018506951 @default.
- W2100094474 cites W2019943197 @default.
- W2100094474 cites W2022103755 @default.
- W2100094474 cites W2026122224 @default.
- W2100094474 cites W2027789718 @default.
- W2100094474 cites W2029652301 @default.
- W2100094474 cites W2032628402 @default.
- W2100094474 cites W2036970411 @default.
- W2100094474 cites W2037261278 @default.
- W2100094474 cites W2037427168 @default.
- W2100094474 cites W2039476804 @default.
- W2100094474 cites W2042579519 @default.
- W2100094474 cites W2044193462 @default.
- W2100094474 cites W2046858735 @default.
- W2100094474 cites W2048367442 @default.
- W2100094474 cites W2056374390 @default.
- W2100094474 cites W2059216887 @default.
- W2100094474 cites W2061552888 @default.
- W2100094474 cites W2065921924 @default.
- W2100094474 cites W2067045621 @default.
- W2100094474 cites W2071468505 @default.
- W2100094474 cites W2081883260 @default.
- W2100094474 cites W2083275699 @default.
- W2100094474 cites W2086559292 @default.
- W2100094474 cites W2093695226 @default.
- W2100094474 cites W2095563205 @default.
- W2100094474 cites W2096779842 @default.
- W2100094474 cites W2097925217 @default.
- W2100094474 cites W2103399712 @default.
- W2100094474 cites W2104641446 @default.
- W2100094474 cites W2105556163 @default.
- W2100094474 cites W2107414185 @default.
- W2100094474 cites W2108494941 @default.
- W2100094474 cites W2110309669 @default.
- W2100094474 cites W2114089007 @default.
- W2100094474 cites W2114097866 @default.
- W2100094474 cites W2117192678 @default.
- W2100094474 cites W2122153421 @default.
- W2100094474 cites W2133929317 @default.
- W2100094474 cites W2138788149 @default.
- W2100094474 cites W2140881716 @default.
- W2100094474 cites W2142446370 @default.
- W2100094474 cites W2145420889 @default.
- W2100094474 cites W2147126871 @default.
- W2100094474 cites W2148925357 @default.
- W2100094474 cites W2154087978 @default.
- W2100094474 cites W2155238509 @default.
- W2100094474 cites W2163606686 @default.
- W2100094474 cites W2163645037 @default.
- W2100094474 cites W2164724442 @default.
- W2100094474 cites W2167559643 @default.
- W2100094474 cites W2169055183 @default.
- W2100094474 cites W2171639907 @default.
- W2100094474 cites W2336204891 @default.
- W2100094474 cites W2952418296 @default.
- W2100094474 doi "https://doi.org/10.1111/j.1365-2893.2009.01246.x" @default.
- W2100094474 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4064679" @default.
- W2100094474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20040045" @default.
- W2100094474 hasPublicationYear "2010" @default.
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