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- W2100095335 abstract "Our aim was to investigate motor activity of the healthy, relatively unprepared colon in the ambulatory state. Twenty-five age- and gender-matched adults had a six-sensor solid-state probe inserted into the proximal transverse colon without sedation. Subjects ambulated freely and ate standard meals. In 528 h of recording, we found a lower ( P < 0.05) area under the curve during the night. Waking induced a threefold increase in motility, whereas meals induced a twofold increase. Women showed less activity ( P < 0.05) in the transverse/descending colon than men. The transverse/descending colon showed more ( P < 0.05) activity than the rectosigmoid colon. Seven patterns were recognized; predominantly, they were simultaneous, propagated, or periodic bursts of 3-cycles/min (cpm) waves. A specialized propagating pressure wave with a high amplitude (>105 mmHg) and a prolonged duration (>14 s) occurred in all subjects (mean 10/day), mostly after waking, after meals, or with defecation. A 3-cpm motor activity was seen in the rectosigmoid region predominantly at night. The colon exhibits a wide spectrum of pressure activity around the clock, with gender and regional differences and circadian rhythm. This comprehensive study provides qualitative and quantitative normative data for colonic manometry." @default.
- W2100095335 created "2016-06-24" @default.
- W2100095335 creator A5017818369 @default.
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- W2100095335 date "2001-04-01" @default.
- W2100095335 modified "2023-10-10" @default.
- W2100095335 title "Ambulatory 24-h colonic manometry in healthy humans" @default.
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- W2100095335 doi "https://doi.org/10.1152/ajpgi.2001.280.4.g629" @default.
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