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• W2100096374 abstract "While in adult human serum, cortisol (F) is present in higher concentrations than cortisone (E), the reverse has been recognized in fetal serum for two decades. To clarify the relationship between biologically active F and its inert metabolite E, the interconversion of these steroids was investigated in various tissues of the human fetus, neonate, child and adult. Tissues obtained within 48 h of death or surgery were incubated with tritiated F and E at 37°C for 2 h with and without added substrate in the absence of cofactors. Conversion of F to E was highest in placenta > fetal kidney and lung > adult testis and ovary > other fetal tissues, while that from E to F was greatest in adult liver > membranes > adult ovary and testis > term uterus. Activity in either direction was greatly decreased at the time of delivery of both mature and premature infants. It is postulated that inactivation of F to E in the hemochorial placenta and in the fetus itself protects the fetus against the growth-inhibiting effects of F, while production of F from E in the membranes and uterine wall contributes to the maintenance of the fetal allograft." @default.
• W2100096374 created "2016-06-24" @default.
• W2100096374 creator A5014571512 @default.
• W2100096374 date "1981-09-01" @default.
• W2100096374 modified "2023-10-18" @default.
• W2100096374 title "Ontogeny of cortisol-cortisone interconversion in human tissues: A role for cortisone in human fetal development" @default.
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• W2100096374 doi "https://doi.org/10.1016/0022-4731(81)90226-0" @default.
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